Journal of Clinical Oncology
Articles in this Issue
Genomic determinants of survival after biliary tract cancer resection.
e16301 Background: Surgical resection is the mainstay for localized, resectable biliary tract cancers (BTCs). Although gen...
Oral fluoropyrimidines as alternatives to intravenous 5-fluorouracil in combination with immune checkpoint inhibitors for recurrent metastatic head neck squamous cell carcinoma.
e18015 Background: Based on the KEYNOTE-048 trial, immune checkpoint inhibitors (ICIs) with or without chemotherapy have b...
Pre-operative chemotherapy versus surgery first with peri-operative interventions in early triple-negative and HER2-positive breast cancer: An open-label, phase 3, randomized controlled trial (PRaCTiSE).
TPS659 Background: Surgery is a mainstay of treatment of breast cancer. Neoadjuvant chemotherapy (NACT) has not proven to...
Effects of short-term fasting compared to free diet in ovarian cancer patients: Results from a two-arm pilot randomized trial.
5517 Background: Short-term fasting (STF) may enhance chemotherapy efficacy by suppressing insulin-driven pro-survival sig...
Amivantamab in <i>EGFR</i> -mutated NSCLC with refractory brain or leptomeningeal metastases: A multi-center real-world study.
8521 Background: The central nervous system (CNS), particularly after progression on third-generation EGFR TKIs, represent...
Guideline-concordant cancer screening among U.S. adults with and without cardiovascular risk factors.
e22565 Background: Uptake of age- and sex-appropriate cancer screening remains suboptimal in the United States. Patients w...
Maintenance pegylated liposomal doxorubicin (PLD) versus active surveillance for advanced soft tissue sarcoma patients who had controlled disease after standard anthracycline-based treatment (MELODY).
TPS11596 Background: The progression-free survival (PFS) associated with first-line chemotherapy for advanced soft tissue...
Texture and color enhancement imaging (TXI) for polyp detection in colorectal neoplasia screening: A meta-analysis of randomized controlled trials.
10582 Background: Colonoscopy remains the gold standard for preventing colorectal cancer; however, variable adenoma detect...
Exploring improved prognostication using PET/CT radiomics in relapsed/refractory, TP53-aberrant diffuse large B-cell lymphoma (DLBCL).
7070 Background: Patients (pts) with TP53-aberrant DLBCL have inferior progression-free survival (PFS) and overall surviva...
The expansion of hematopoietic cell transplantation in patients aged >75 years: A CIBMTR analysis, 2019–2023.
e13769 Background: Hematopoietic cell transplantation (HCT) is increasingly utilized in older adults; however, patients ag...
Developing quality cancer survivorship care competencies for primary care: A modified Delphi study.
e13780 Background: Most of the growing population of people living with and beyond cancer will access primary care. Howeve...
A real-world analysis of dyslipidemia and attributable risk in lorlatinib-treated ALK-positive lung cancer patients.
e24190 Background: Lorlatinib as a first-line treatment for ALK-positive NSCLC can significantly prolong survival, and the...
Correlative analysis of ctDNA in CheckMate-9X8 study of frontline treatment with mFOLFOX6, bevacizumab with or without nivolumab in metastatic colorectal cancer.
3584 Background: The CheckMate 9X8 study evaluated ctDNA as biomarker to predict treatment benefit in metastatic colorecta...
Surufatinib combined with anti-PD-1/PD-L1 antibody in the second line or monotherapy in third line treatment of advanced hepatocellular carcinoma: A single-arm, open-label, multi-center phase II study.
e16172 Background: Surufatinib is a selective inhibitor of VEGFRs, FGFR1, and CSF-1R, demonstrating dual mechanisms of ant...
An indirect comparison of EGFR TKI combination therapies in advanced <i>EGFR</i> -mutated NSCLC: Comparing manual and AI-generated analyses.
e20625 Background: The treatment landscape for stage IV EGFR-mutated non-small cell lung cancer (NSCLC) is rapidly evolvin...
Envafolimab combined with lenvatinib and gemcitabine plus cisplatin in advanced biliary tract cancer as first-line treatment: A multicenter, single-arm, open-label, phase II study (ENLIGHTEN study).
4152 Background: The prognosis of advanced biliary tract cancer (BTC) remains unsatisfactory despite the use of first-line...
Group-based versus individualized exercise programs in lung cancer: Results from the randomized crossover LungFit study.
e20101 Background: Patients with lung cancer frequently experience reduced functional capacity and impaired quality of lif...
Phase 1 study of NTX1088, a first-in-class anti-PVR monoclonal antibody, as monotherapy and combined with pembrolizumab, in patients with advanced solid malignancies.
2518 Background: Poliovirus Receptor (PVR; CD155), a transmembrane protein upregulated across multiple solid tumors and as...
Pre-existing mental health diagnosis and colorectal cancer outcomes.
e15711 Background: Mental health disorders are common among patients (pts) with cancer, sometimes associated with delays i...
Spatial PK/PD profiling in human ex vivo tumor slices to identify exposure-limited niches driving heterogeneous response to a TROP2-targeting ADC in NSCLC.
e15040 Background: TROP2-targeting antibody–drug conjugates (ADCs) have demonstrated promising clinical activity in non-sm...
Prognostic role of ATM in gastric cancer: A systematic review and meta-analysis.
e16342 Background: Gastric adenocarcinoma remains one of the primary causes of cancer-related mortality worldwide. There i...
Randomized controlled trial of a psychosocial digital application (THRIVE-MM) for patients living with multiple myeloma.
1513 Background: Patients living with multiple myeloma (MM) struggle with considerable quality of life (QOL) impairments,...
A cardio-oncologic burden: Leukemia-associated arrhythmia mortality in the United States (1999-2023).
e18634 Background: Leukemia remains a major contributor to cancer-related mortality in the United States. Cardiac arrhythm...
Trends in ovarian function suppression use among premenopausal women with breast cancer: A longitudinal analysis from 2015-2023.
e12694 Background: Ovarian function suppression (OFS) combined with endocrine therapy (ET) using tamoxifen or an aromatase...
Prospective clinical activity and preclinical basis of panitumumab-based EGFR blockade in SMARCB1-deficient renal medullary carcinoma (RMC): A collaborative multi-institutional study.
4520 Background: RMC is a rare, exceptionally aggressive malignancy that predominantly affects young individuals of Africa...