Journal of Clinical Oncology
Articles in this Issue
Atrial fibrillation as an acute severity amplifier during cancer hospitalizations: A National Inpatient Sample analysis, 2018–2022.
e23098 Background: Atrial fibrillation (AF) is highly prevalent among patients with cancer and is frequently treated as a...
Health care utilization and management patterns of asymptomatic incidental pulmonary embolism in cancer patients.
e13562 Background: Asymptomatic incidental pulmonary embolism (iPE) is increasingly detected in cancer patients on routine...
Identification of prognostically relevant residual tumor burden in glioblastoma after surgery: A comparative analysis of MR-based RANO resect classes vs [ <sup>18</sup> F]FET PET.
2068 Background: Accurate assessment of postoperative residual tumor burden is critical in IDH...
Soluble CD137 in health and disease: A systematic review and meta-analysis.
e14528 Background: Soluble CD137 (sCD137), produced by regulatory T cells, plays a critical role in immune response regula...
RedTail: A next-generation systemic platform for tumor-localized expression of BiTEs and immune activation.
e14562 Background: RedTail is a next-generation gene therapy platform engineered for systemic delivery and highly selectiv...
Incidence and survival rates in pediatric and adolescent melanoma in the United States, 2001-2022.
9593 Background: Melanoma represents a significant malignancy in children, adolescents, and young adults. Recent trends in...
Treatment patterns and outcomes after metastatic recurrence following perioperative chemoimmunotherapy in triple-negative breast cancer (mTNBC).
e13131 Background: Data on the management and prognosis of metastatic recurrence after perioperative chemoimmunotherapy in...
Global burden of stomach cancer attributable to alcohol use (1990-2023): A comprehensive epidemiological analysis.
e16361 Background: Alcohol consumption is a Group 1 carcinogen by the International Agency for Research on Cancer, yet its...
Turning clinically approved PARP inhibitors into immunotherapy sensitizers by reprogramming the tumor microenvironment in colorectal cancer.
e14552 Background: PARP1 promotes tumor survival through compensatory DNA-repair pathways and inflammatory signaling. Whil...
Inpatient outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in the United States, 2018–2023.
e15605 Background: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is a highly complex on...
The association of lymph node yield and survival after neoadjuvant immunotherapy for head and neck cancer: An NCDB analysis.
e18120 Background: Comprehensive lymph node resection is a quality measure previously associated with survival for head an...
Adjuvant antibody-drug conjugate (ADC) eligibility and corresponding prognosis in HER2+ early breast cancer (eBC): A US-based real-world comparison of KATHERINE and DESTINY-Breast05 populations.
535 Background: The KATHERINE trial established adjuvant T-DM1 as standard of care (SoC) treatment for patients with HER2+...
Connectome-sparing stereotactic radiosurgery: Results from the phase II COG-SRS trial.
2002 Background: Cognitive decline remains common after radiosurgery. The cognition-sparing stereotactic radiosurgery tria...
Real-world brain metastasis outcomes with T-DXd versus tucatinib-based therapy in second-line HER2-positive metastatic breast cancer.
1051 Background: Brain metastases (BM) remain a major cause of morbidity and mortality in HER2+ metastatic breast cancer (...
Synergistic efficiency of methylene blue and carbon nanoparticles for sentinel lymph node biopsy in early breast cancer: A large-scale real-world cohort study of 1,355 patients.
583 Background: Sentinel lymph node biopsy (SLNB) using radioisotopes and fluorescence imaging is the gold standard but re...
Variants of uncertain significance and contralateral risk-reducing mastectomy in early-stage breast cancer across safety-net and private hospital settings.
10603 Background: Germline genetic testing informs surgical decisions in early-stage breast cancer. Guidelines recommend c...
A systematic review and meta-analysis of artificial intelligence–assisted colon capsule endoscopy for colorectal polyp detection.
e15520 Background: Colorectal cancer remains a leading cause of cancer-related mortality worldwide, with early polyp detec...
Histology-dependent survival and treatment benefit in primary tracheal cancer: A population-based analysis.
e23386 Background: Primary tracheal cancer is a rare thoracic malignancy representing only 0.1-0.4% of all malignancies. E...
HER2 discordance in upper gastrointestinal cancers in a US-based analysis.
e16086 Background: HER2 overexpression is present in 20 to 30% of advanced upper gastrointestinal (UGI) cancers and can be...
Tobacco use–driven lung cancer mortality in the United States: A population-based analysis from 2003 to 2023.
e20039 Background: Lung cancer (LC) is the leading cause of cancer death worldwide, with tobacco use as its primary risk f...
Temporal trends and racial disparities in cancer-related mortality among individuals with substance use involvement in the United States, 1999–2023.
e22630 Background: Cancer-related mortality associated with substance use is an increasing public health concern in the Un...
Features of the content of components of the vascular endothelial growth factor system in the blood of men with recurrent soft tissue sarcomas.
e23550 Background: Soft tissue sarcomas (STS) have been studied to a lesser extent than tumors of epithelial origin. The m...
Neoadjuvant radiotherapy combined with lenvatinib and sintilimab in patients with resectable hepatocellular carcinoma with portal vein tumor thrombus: An open-label, single-arm, multicenter, prospective phase I clinical trial.
4113 Background: Surgical resection remains the potentially curative treatment for resectable hepatocellular carcinoma (HC...
Expression of nectin-4 in germ-cell tumors.
e17009 Background: Nectin-4 is a cell adhesion molecule and therapeutic target in several malignancies, including urotheli...
Development of a point-of-care clinical decision support system to optimize total cost of care, while preserving quality outcomes: Integration of economic, clinical, pathological, genomic data, and national guidelines.
e23301 Background: Rising cancer care costs challenge patients and policymakers, with approximately 80% of expenditures dr...