Journal of Clinical Oncology
Articles in this Issue
Updated analysis of adjuvant chemotherapy after radical resection of metachronous colorectal cancer metastases.
e15618 Background: The role of adjuvant systemic therapy following complete (R0) resection of metachronous colorectal canc...
A first-in-human study of ATX-295, an oral inhibitor of KIF18A, in patients with advanced or metastatic solid tumors, including ovarian cancer.
TPS3167 Background: ATX-295 is an oral inhibitor of KIF18A, an adenosine triphosphate (ATP)-dependent, plus end-directed m...
Avelumab + sacituzumab govitecan (Ave + SG) vs avelumab monotherapy (Ave mono) as first-line (1L) maintenance treatment for advanced urothelial carcinoma (aUC): Updated subgroup analyses of JAVELIN Bladder Medley based on metastatic sites.
4568 Background: Ave 1L maintenance is a recommended treatment option for patients (pts) with aUC without progression afte...
Impact of earlier time of first cycle immunotherapy administration on progression-free survival in real-world metastatic non–small cell lung cancer.
e20579 Background: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced non-small cell lung c...
Pulmonary embolism-related mortality in pancreatic cancer patients aged ≥45 years in the United States, 1999-2023: A CDC WONDER analysis.
e16411 Background: Pancreatic cancer is among the most prothrombotic malignancies; however, long-term national trends in p...
Predictors of persistent opioid use following curative-intent radiation for head and neck cancer.
e18099 Background: Head and neck cancer (HNC) patients often experience pain from intense radiation treatment. Opioids wor...
Anal cancer incidence among Medicaid enrollees with HIV in the United States.
e16479 Background: Anal cancer incidence remains elevated among people with HIV (PWH); however, incidence among PWH enroll...
Comprehensive genomic profiling of adenoid cystic carcinoma using the AACR Genie Database.
6072 Background: Adenoid cystic carcinoma (ACC) is a rare neoplasm of the secretory glands, comprising <1% of head and...
Financial toxicity and care access barriers among adolescent and young adult versus older melanoma survivors: A population-based analysis of 2021-2024 National Health Interview Survey data.
e21592 Background: Adolescent and young adult (AYA) cancer survivors may experience disproportionate financial toxicity an...
U.S. patient enrollment in pivotal clinical trials that supported FDA oncology approvals from 2020 to 2025.
e23030 Background: Adequate enrollment of U.S. patients in pivotal clinical trials designed to support applications for FD...
Clinical outcomes in <i>TP53</i> -mutated clonal hematopoiesis: Single-center retrospective study.
6594 Background: Clonal hematopoiesis (CH), including CH of indeterminate potential (CHIP) and clonal cytopenia of undeter...
Suicide gene therapy for recurrent glioblastoma using allogeneic bone marrow–derived mesenchymal stem cell gene delivery (MSC/CD): A first-in-human, dose-escalation phase I clinical trial.
2071 Background: Glioblastoma (GBM) remains an incurable brain tumor characterized by complex heterogeneity and poor progn...
Clinical and molecular landscape of MTAP-deleted thoracic tumors across Western and Asian cohorts: Implications for synthetic lethal targeting.
e20713 Background: Methylthioadenosine phosphorylase (MTAP) deletion creates a synthetic lethal vulnerability to protein a...
Liquid biopsy to stratify metastatic breast cancer progression risk using multi-analyte cell subtyping prior to systemic therapy.
e15060 Background: In metastatic Breast Cancer (mBC) Circulating Tumor Cells (CTCs) are an established prognostic indicato...
Cost-saving analysis of neoadjuvant versus adjuvant immunotherapy in clinical stage III melanoma: A real-world Brazilian perspective.
e21544 Background: Neoadjuvant immunotherapy has become a new standard for resectable clinical stage III melanoma, driven...
Clinical factors associated with durable response to atezolizumab in extensive-stage small-cell lung cancer: A real-world analysis in Moscow.
e20160 Background: Atezolizumab (A) in combination with platinum-etoposide chemotherapy represents the current standard of...
Real-world efficacy and safety of sintilimab combined with nab-paclitaxel and S-1 as first-line treatment for locally advanced or metastatic pancreatic ductal adenocarcinoma: A single-center retrospective study.
e16373 Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a poor prognosis, and effective first-line t...
Has racial and ethnic representation in oncology clinical trials changed?: A 30-year systematic analysis using artificial intelligence.
11079 Background: Despite societal emphasis on racial and ethnic representation in oncology trials, it remains unclear whe...
Characteristics and survival of 4N and non-4N metastatic neuroblastoma across treatment eras: A report from the International Neuroblastoma Risk Group Task Force.
10007 Background: Patients with metastatic neuroblastoma confined to distant lymph nodes (4N) were identified as a subgrou...
Health-related quality of life.
1109 Background: Trials typically pool patient-reported outcomes across demographics, assuming baseline differences reflec...
Real-world outcomes of immune checkpoint inhibitors in patients aged 65–74 versus ≥75 years with non-small cell lung cancer.
e20642 Background: Immune Checkpoint Inhibitors (ICIs) have shown significant survival benefit in the treatment of Non-Sma...
Major adverse cardiovascular events in androgen receptor signaling inhibitor–treated patients with metastatic castration-sensitive prostate cancer.
5107 Background: Cardiovascular disease is highly prevalent in the predominantly older male population with metastatic cas...
PUNCH03: Preliminary results from a phase II study of disitamab vedotin combined with tislelizumab and Bacillus Calmette-Guerin (BCG) in Her2-positive high-risk non-muscle-invasive bladder cancer (HR NMIBC).
4597 Background: Disitamab vedotin (RC48) was a novel antibody drug conjugate that targets the Her2 protein. The KEYNOTE-0...
Assessment of recurrence risk in stage IIB/C melanoma across time: Implications for stratification and surveillance.
9568 Background: Stage IIB/C cutaneous melanoma is associated with high recurrence risk, however stratification of risk in...
The impact of surgery and the type of immune check point inhibitors (ICI) in patients with locally advanced head and neck squamous cell carcinoma (LA HNSCC) receiving immunotherapy: An updated systematic review and meta-analysis of randomized controlled trials.
e18081 Background: Locally advanced head and neck squamous cell carcinoma (LA HNSCC) remains a clinical challenge with hig...