Journal of Clinical Oncology
Articles in this Issue
Second-generation H1 antihistamine use with survival and immune-related outcomes in lung cancer and melanoma patients receiving immune checkpoint inhibitors.
11153 Background: Immune checkpoint inhibitors (ICIs) are standard of care for melanoma and lung cancer but are associated...
TP53 loss in relation to mTORC1 activation and autophagy suppression shaping an immune-cold phenotype in microsatellite-stable colorectal cancer.
e15521 Background: Loss of TP53 is one of the most common alterations in microsatellite-stable colorectal cancer (MSS CRC)...
SARS-CoV-2 infection, vaccination, and MGUS progression with COVID-19 outcomes in multiple myeloma: A systematic review.
e19550 Background: SARS-CoV-2 infection and vaccination have been associated with immune perturbations that may affect pla...
Profiling <i> <i>NRG1</i> </i> fusions in NSCLC: A comparative analysis of DNA+RNA-NGS and DNA-NGS assays.
e20742 Background: The neuroregulin 1 ( NRG1...
The corticosteroid timing paradox in immune checkpoint inhibitor–treated solid tumors and its association with overall survival: A TriNetX retrospective cohort study.
11140 Background: Systemic corticosteroids are frequently used in patients receiving immune checkpoint inhibitors (ICIs) f...
Comparative effectiveness and safety of axicabtagene ciloleucel versus lisocabtagene maraleucel in large B-cell lymphoma: A real-world target trial emulation.
11021 Background: Axicabtagene ciloleucel (axi-cel) and lisocabtagene maraleucel (liso-cel) are approved CD19-directed CAR...
An AI-powered, human-in-the-loop, real-time registry platform to enable clinical trials, pragmatic studies, and prospective external control arms (ProECA) at scale in US community practices.
11058 Background: Drug development is requiring novel approaches such as prospective external controls to reduce developme...
Beyond uveal melanoma: Genomic landscape and immunogenic profiles of <i>GNAQ</i> and <i>GNA11</i> mutations in metastatic solid tumors.
e15115 Background: Activating mutations in GNAQ and GNA11...
Harnessing OMOP-CDM for multisite collaborations to measure cardiovascular risk factors and cardiovascular disease in the early survivorship period for children, adolescents, and young adults.
10009 Background: The Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) is an international effort t...
Definitive bladder/pelvic radiation after enfortumab vedotin–pembrolizumab for advanced urothelial carcinoma.
e16589 Background: Treatment with enfortumab vedotin and pembrolizumab (EV-P) is highly effective in patients (pts) with a...
Neoadjuvant cadonilimab plus chemotherapy for locally advanced gastric/gastroesophageal junction cancer: A single-arm, phase II trial.
4100 Background: Cadonilimab plus chemotherapy is a promising treatment option in the first-line setting of gastric cancer...
Early chemo-induced TME alterations as a predictor of response to PD-1 blockade in AVPC: Single-cell data from C3NIRA.
5065 Background: Aggressive variant prostate cancer (AVPC) criteria enrich for androgen-indifferent disease that is highly...
Real-world incidence, prevalence, and short-term outcomes in young-onset breast cancer.
e13092 Background: Young-onset breast cancer(diagnosed at age < 40 years) is increasing in incidence,yet contemporary r...
Breast cancer screening uptake and barriers among women in Hue, Vietnam: A cross-sectional survey.
e13530 Background: Breast cancer is the leading cancer in women in Vietnam, with almost 25,000 cases per year. However, th...
Evaluation framework for monoclonal B-cell lymphocytosis.
e22571 Background: Monoclonal B cell lymphocytosis (MBL) is recognized as a precursor to chronic lymphocytic leukemia (CLL...
Discovery from single-cell RNA sequencing profiles of 18 CPTAC glioblastoma patients and validation in bulk profiles of 138 TCGA patients and two human-derived cell lines of a whole-transcriptome predictor of overall survival and drug targets by using quantum mechanics–based AI/ML.
3019 Background: Single-cell, more than bulk, multi-omic data, are small-cohort, noisy, and high-dimensional, and extremel...
Clinical characteristics and neighborhood factors associated with patient survival among adolescents and young adults with bone sarcoma.
e23500 Background: Compared to pediatric patients, adolescents and young adults (AYA) with bone sarcomas experienc...
Beyond imatinib: Real-world mortality patterns across modern second-line TKIs in CML.
e18594 Background: Tyrosine kinase inhibitors (TKIs) have altered management and outcomes of chronic myeloid leukemia (CML...
The AI paradox in precision oncology: Prospective blinded validation of large language models against molecular tumor board.
11047 Background: Molecular tumor boards (MTBs) are central to precision oncology but remain limited in accessibility. Lar...
Effect of GLP-1 receptor agonism on anthracycline- and HER2-targeted therapy–induced cardiac dysfunction and systemic inflammation in non-diabetic preclinical models.
e12524 Background: Sequential administration of anthracyclines and HER2-targeted agents represents a highly effective ther...
First-line NALIRIFOX in patients with metastatic pancreatic ductal adenocarcinoma and pre-existing diabetes: NAPOLI 3 post hoc analysis.
4195 Background: Approximately 29% of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) present with pre-e...
Metabolic comorbidity burden and oncologic features of early-onset colorectal cancer stratified by hepatic steatosis.
e15696 Background: Early-onset colorectal cancer (EO-CRC) incidence is rising, and emerging evidence links EO-CRC with met...
Comparative outcomes of [^177Lu]Lu-PSMA-617 versus radium-223 in bone-metastatic castration-resistant prostate cancer: A real-world propensity-matched analysis.
e17070 Background: Two guideline-recognized radiopharmaceuticals differ in mechanism and indication. Radium-223 (Ra-223),...
Pancreatectomy with and without preoperative biliary drainage: A systematic review and meta analysis.
e16426 Background: Preoperative biliary drainage (PBD) is commonly performed in patients with obstructive jaundice due to...
Where do adults with pancreatic cancer die in the United States: A retrospective analysis of 25 years.
e24042 Background: Pancreatic cancer remains a leading cause of cancer-related morbidity and mortality. With limited survi...