Journal of Clinical Oncology
Articles in this Issue
Benefit of chemotherapy on survival in women aged ≥ 70 with HR-positive, HER2-negative breast cancer and N2-like nodal burden: A population-based analysis.
e12703 Background: High-risk localized hormone receptor (HR)-positive, HER2-negative breast cancer is often treated with c...
Neoadjuvant nivolumab plus ipilimumab and adjuvant nivolumab in patients with localized microsatellite instability-high (MSI)/mismatch repair deficient (dMMR) oeso-gastric adenocarcinoma: Long-term follow-up of the GERCOR NEONIPIGA phase II study.
4099 Background: Neoadjuvant nivolumab and ipilimumab in localized MSI/dMMR gastric cancer were evaluated in the NEONIPIGA...
Time to treatment initiation for triple-negative breast cancer in Brazil: A call for public health action.
1544 Background: Timely initiation of treatment is a critical determinant of outcomes in breast cancer. In Brazil, nationa...
Multiomic spatial analysis of tumor microenvironment during neuroendocrine (NE) transformation in <i>EGFR</i> -mutant LUAD.
8085 Background: Histological transformation of EGFR mutant lung cancer adenocarci...
daNIS-3: A phase II platform study of NIS793 and anti–PD-1 combined with standard of care (SoC) anti-cancer therapy for the second-line (2L) treatment (tx) of microsatellite-stable colorectal cancer (MSS CRC).
3529 Background: Despite advances in tx of MSS CRC including targeted tx, the prognosis remains poor. The daNIS-3 study (N...
Radiotherapy followed by systemic therapy and tislelizumab in microsatellite-stable rectal cancer with synchronous unresectable metastases: Updated results of the MIRACLE-2 study.
3578 Background: Microsatellite-stable (MSS) tumors comprise ~95% of metastatic colorectal cancer cases and exhibit intrin...
Patient-level OS prediction in NSCLC combining real-world data and published trial results.
e20526 Background: The majority of early-phase clinical trials in oncology are single-arm trials. External comparator arms...
Explainable machine learning for continuous transcriptomic modeling of metastatic risk in prostate cancer (MET-score).
5129 Background: Metastatic progression is the leading cause of mortality in prostate cancer, yet clinicopathological stra...
An innovative team approach to improve SCLC care across an integrated health system.
8111 Background: Small cell lung cancer (SCLC) is a highly aggressive cancer, with improved overall survival due to recent...
Pathologic treatment effect and first recurrence behavior after curative liver surgery for HCC.
e16287 Background: Locoregional therapy (LRT) is frequently used before curative-intent liver resection or transplantation...
County-level residential radon exposure, testing patterns, and cancer incidence in Michigan.
e22542 Background: Radon is a well-established lung carcinogen and the second leading cause of lung cancer in the United S...
Childcare provision during breast cancer radiation therapy: Piloting of the Waiting Room Watchers program through the Navigator-Assisted Hypofractionation (NAVAH) program.
e23113 Background: Childcare responsibilities remain a major barrier to treatment adherence among women undergoing cancer...
Developing workshops to enhance self-efficacy among patients in cancer survivorship: A collaborative partnership between physiatry and a community cancer support network.
e13786 Background: Cancer survivors face physical, emotional and psychosocial challenges after treatment. There is evidenc...
Phase 1/2a study of concomitant radiotherapy with olaparib and temozolomide in unresectable high-grade glioma patients: Final results from the phase 2a step (OLA-TMZ-RTE-01).
2005 Background: Although the Stupp protocol (radiotherapy + temozolomide (TMZ)) remains the cornerstone of glioblastoma (...
Site and extent of distant metastasis at diagnosis as used to stratify survival in head and neck cancer: A population-based analysis.
e18041 Background: Distant metastases in head and neck cancer (HNC) are associated with poor prognosis. Population-level d...
Geographic disparities in availability of advanced therapies for myeloma from rural-urban access limitations: A population-based registry analysis.
e13511 Background: Autologous stem cell transplantation (ASCT) remains standard consolidation therapy for transplant-eligi...
Association of patient-reported stress and depression symptoms with ER-specific tumor transcriptional signatures in breast cancer (BC).
565 Background: Psychological distress is common among women with BC, yet tumor-level biological correlates remain poorly...
Evaluating and validating immune effector dysfunction as a biomarker in bladder cancer.
e16601 Background: Checkpoint inhibitors (CPI) have transformed bladder cancer treatment, yet response rates remain limite...
Pollution and progression: Air quality and stage of lung cancer diagnosis across the U.S.
8003 Background: Air pollution contributes to increased lung cancer incidence, but whether it accelerates tumor progressio...
Mortality trends from malnutrition and gastrointestinal cancer in US adults: A retrospective analysis.
e15675 Background: Gastrointestinal cancer is the significant public health issue worldwide, contributing to a substantial...
Intrathecal (IT) therapy–associated pseudoprogression (PsP) in leptomeningeal metastases (LM) from solid tumors.
2037 Background: Intracranial PsP following systemic immunotherapy has been recognized. IT therapy is a cornerstone of LM...
Association between T-cell LAG-3 expression and clinical benefit in patients with type 2 diabetes and metastatic melanoma treated with immune checkpoint inhibitors.
e14578 Background: Anti-PD-1/anti-LAG-3 combination checkpoint inhibitors, such as nivolumab/relatlimab (nivo/rela), show...
Real-world analysis of eribulin sequencing and outcomes in advanced breast cancer: An LMIC cohort study focusing on line of therapy and prior cyclin-dependent kinase 4/6 inhibitor exposure.
e13050 Background: In Low-and-Middle-Income Countries (LMICs), eribulin is often a late-line salvage. With increasing use...
Cachexia as an inpatient vulnerability phenotype in lung cancer: A National Inpatient analysis.
e23225 Background: Cancer cachexia is a multisystem metabolic syndrome characterized by involuntary tissue catabolism and...
Five-year overall survival in lung adenocarcinoma: Real-world results from three French nationwide cohorts (2000–2010–2020).
8600 Background: Long-term (5-year) real-world overall survival (OS) in non–small cell lung cancer (NSCLC) remains poorly...