Journal of Clinical Oncology
Articles in this Issue
PD-1 inhibitor plus VEGFR-2 inhibitor and chemotherapy versus chemotherapy alone for locally advanced gastric cancer: A systematic review and meta-analysis.
e16125 Background: Despite multimodality treatment, pathological response rates remain suboptimal in patients with locally...
Nilvanstomig (ZG005), an anti-PD-1/TIGIT bispecific antibody, plus bevacizumab vs. sintilimab plus bevacizumab biosimilar as first-line therapy for advanced hepatocellular carcinoma: A randomized, multi-center, phase II trial.
4014 Background: Checkpoint inhibitors combined with anti-angiogenic therapy represents one of the standard first-line the...
Impact of pre-treatment antibiotic exposure on immunotherapy outcomes in gastrointestinal malignancies: A multicenter propensity-matched real-world cohort study.
e15598 Background: Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of gastrointestinal (GI) m...
Randomized phase 2 study to evaluate the efficacy and safety of silevertinib in combination with temozolomide in newly diagnosed patients with EGFRvIII-positive IDHwt MGMT unmethylated glioblastoma.
TPS2098 Background: Targeted therapy for patients with newly diagnosed glioblastoma (ND-GBM) has made little progress. Fir...
Mortality trend from multiple myeloma with hypertensive diseases as a contributing cause in the United States, 1999–2024: A CDC WONDER analysis across age, sex, and geographic variables.
e19530 Background: Multiple myeloma (MM) is a malignancy frequently accompanied by comorbid conditions such as hypertensiv...
Efficacy and safety of camrelizumab combined with docetaxel and carboplatin as neoadjuvant therapy for triple-negative breast cancer: The HELEN-Trio 011 randomized clinical trial.
1009 Background: The KEYNOTE-522 trial demonstrated that adding a PD-1 inhibitor to neoadjuvant chemotherapy significantly...
Current real-world treatments in patients with metastatic colorectal cancer (mCRC) in US clinical practice.
e15604 Background: As the landscape of mCRC treatment continues to evolve, it is important to understand real-world treatm...
Puxitatug samrotecan (AZD8205) vs chemotherapy in patients with B7-H4–selected advanced/metastatic endometrial cancer: The phase 3 randomized Bluestar-Endometrial01 (BE01)/GOG-3110/ENGOT-EN28 trial.
TPS5647 Background: The transmembrane glycoprotein B7-H4 is highly expressed in endometrial cancer (EC), with limited expr...
A phase II trial of binimetinib in combination with encorafenib in patients with pancreatic malignancies and a somatic <i>BRAF</i> <sup>V600E</sup> mutation.
4219 Background: Pancreatic ductal adenocarcinoma (PDAC) remains a notoriously difficult-to-treat malignancy, with limited...
Improving patient self-management in hepatocellular carcinoma using care sequence plans: A comparative survey study.
e23327 Background: Care Sequence plans, a 4R Oncology model tool (Right Information and Right Care for the Right Person at...
Long-term impacts of stomatitis and related lesions on clinical outcomes in lung cancer patients receiving chemotherapy and immunotherapy: Insights from a propensity-matched cohort study.
e24205 Background: Stomatitis and related oral lesions are common adverse effects of antineoplastic therapies in lung canc...
Insurance and racial disparities in palliative care utilization and end-of-life outcomes in metastatic pancreatic cancer: A national analysis.
e16439 Background: Disparities in palliative care access and end-of-life (EOL) care intensity by insurance and race in met...
Association between smoking, tumor genetics, and outcomes in men with metastatic prostate cancer.
5052 Background: Smoking has been associated with increased metastatic prostate cancer (mPC) mortality, but the mechanisms...
Evolution of treatment and survival in primary tracheal cancer: Insights from a global real-world dataset.
e18141 Background: Primary tracheal cancer is a rare malignancy associated with poor survival and highly heterogeneous tre...
HRD as a predictor of response to platinum-based chemotherapy and PARP inhibitors in a Chinese ovarian cancer population.
e17571 Background: Homologous Recombination Deficiency (HRD) predicts response to platinum-based chemotherapy and PARP inh...
Impact of substance use disorder on pneumonia hospital outcomes in chronic lymphocytic leukemia: An inpatient nationwide analysis.
e19034 Background: CLL is associated with immune dysfunction and severe infections, particularly pneumonia (PNA). Substanc...
Sequential therapy in BRAF-mutant melanoma: Comparison of combination immunotherapy anti-CTLA4 and anti–PD-1 versus anti–PD-1 monotherapy after targeted treatment failure.
e21527 Background: The optimal immunotherapy strategy for patients with BRAF-mutant advanced melanoma who progress on firs...
Geographic migration patterns of practicing medical oncologists in the United States, 2020-2025.
1527 Background: The regional provision of cancer care in the United States (US) remains plagued by disparities along the...
Prognostic effect of neoadjuvant chemotherapy in gBRCA-mutated compared to gBRCA wild-type patients with advanced HGSOC treated with first-line PARP inhibitor maintenance: A large series propensity score–matching analysis.
5602 Background: Recent results from the TRUST trial (ENGOTov33/AGO-OVAR OP.7) have renewed interest in the prognostic rol...
Global insights into survival outcomes and unmet therapeutic needs in <i>KRAS</i> -mutant gallbladder cancer: A comprehensive federated network analysis.
4141 Background: Gallbladder cancer (GBC) is an aggressive malignancy with limited systemic options and poor survival. KRA...
De-escalation of neoadjuvant chemotherapy for HER2-positive breast cancer: A systematic review and meta-analysis.
616 Background: The addition of carboplatin to taxane-based dual HER2 blockade (TCbHP) is a standard neoadjuvant regimen f...
Adjuvant radiotherapy versus observation following curative surgery for early-stage oral squamous cell carcinoma (AREST; CTRI/2017/07/009114).
6000 Background: The role of adjuvant radiotherapy (RT) in early-stage, node-negative oral squamous cell carcinoma...
Regional and gender disparities in lung cancer mortality in Guatemala.
8074 Background: Lung cancer is the leading cause of cancer-related deaths worldwide and a major contributor in Latin Amer...
Impact of preoperative breast MRI on locoregional staging and management in early breast cancer.
e12510 Background: The role of preoperative breast MRI in early breast cancer remains controversial. We evaluated the impa...
Prognostic significance of HMGB1 expression as a biomarker of immunogenic cell death in patients with leiomyosarcoma and undifferentiated pleomorphic sarcoma treated with chemo-immuno–based regimens.
e23526 Background: Immunogenic cell death (ICD) is a functionally unique form of apoptosis that triggers a robust tumor-sp...