Journal of Clinical Oncology
Articles in this Issue
Prognostic value of serial liquid biopsy EGFR mutation monitoring in Hispanic patients with advanced NSCLC treated with osimertinib.
e20761 Background: The prognostic role of serial circulating tumor DNA (ctDNA) dynamics during osimertinib treatment has b...
Insurance and cost-related access barriers to specialty oral anticancer medications for blood cancers in a nationwide sample of Medicare and commercially insured patients.
11031 Background: Specialty oral anticancer medications improve survival across blood cancers but may have access challeng...
Conversational AI-assisted exploratory data analysis (CA-EDA): A comparative evaluation of commercial large language models for clinical trial analysis.
1636 Background: Conventional analysis of clinical trial data requires statistical expertise, time and effort. Previous AI...
Characterization of the immune infiltrate and the chromatin 3D structure of gastric tumors from Mexican patients.
e16145 Background: Identifying cellular populations within tumors and theirmicroenvironment, along with genome structure c...
Evaluation of drug-drug interactions and progression-free survival in patients with prostate cancer treated with androgen receptor pathway inhibitors using the Drug-PIN software: The DDI-AID, a real-world observational study from the Meet-URO Network.
e17019 Background: Androgen Receptor Pathway Inhibitors (ARPIs) are commonly used in metastatic prostate cancer (mPC). Giv...
Real-world evaluation of the decentralized MSK-ACCESS powered with SOPHiA DDM liquid biopsy assay for comprehensive tumor profiling.
e15084 Background: MSK-ACCESS powered with SOPHiA DDM is a decentralized next-generation sequencing (NGS) assay for circul...
Predicting chemotherapy benefit in premenopausal women with intermediate genomic scores using deep learning.
602 Background: The TAILORx trial demonstrated that adjuvant chemotherapy can be safely omitted in postmenopausal women wi...
Preliminary results of a randomized phase II trial of chidamide plus fulvestrant with or without sintilimab in HR+/HER2- advanced breast cancer after progression on CDK4/6 inhibitors (CISFORT).
e13051 Background: Chidamide is a subtype-selective histone deacetylase (HDAC) inhibitor that has demonstrated clinical ac...
Erythropoietin receptor (EPOR) expression as an independent prognostic biomarker in clear cell renal cell carcinoma, beyond angiogenesis, hypoxia, and erythropoietin ligand.
e16520 Background: Clear cell renal cell carcinoma (ccRCC) is characterized by dysregulated hypoxia and angiogenesis signa...
Ultra-lightweight deep learning for glioma detection: MobileNet-based MRI classification to enable real-time neuro-oncology deployment.
e14085 Background: Gliomas, the most common CNS tumors, are associated with substantial morbidity and mortality. Magnetic...
Diagnostic yield of percutaneous versus open surgical biopsy for tibial bone lesions: A retrospective review.
e23505 Background: Accurate histologic diagnosis is critical for tibial bone tumors, which are among the most common sites...
Efficacy and safety of continuous intra-arterial cisplatin and recombinant human endostatin combined with systemic chemotherapy in osteosarcoma: A phase II study.
11523 Background: Previous studies have demonstrated that preoperative intra-arterial cisplatin infusion elicits a favorab...
The weekend effect in spontaneous tumor lysis syndrome in patients with hematological malignancy: National trends in dialysis utilization, mortality, and resource use in the United States.
e18632 Background: Spontaneous tumor lysis syndrome (sTLS) is a rare but highly lethal oncologic emergency. Whether outcom...
Detecting resistant subpopulations by profiling drug response heterogeneity in patient-derived cancer organoids (PDCOs) following first-line treatment.
e15603 Background: Colorectal cancer (CRC) frequently progresses due to resistance to standard first-line chemotherapy, su...
Decision support for treatment of patients with glioblastoma: A systems biology approach enabled by explainable AI.
2081 Background: Glioblastoma (GBM) patients (pts) have median survival of 15 months and 5-year survival <7% with stand...
Targeting tumor–stroma crosstalk with ICAM1 antibody–drug conjugates to enable dual-compartment therapy in ovarian cancer.
e15024 Background: Antibody–drug conjugates (ADCs) have reshaped the treatment of solid tumors, yet their efficacy in ovar...
Combined safety and efficacy results from three clinical studies evaluating alpha radiotherapy for advanced pancreatic cancer.
4215 Background: Pancreatic cancer (PDAC) remains associated with poor prognosis and limited treatment options, particular...
Real-world outcomes of early unfractionated heparin use in NSTEMI patients with acute leukemia and severe thrombocytopenia.
6539 Background: Current AHA/ACC guidelines provide limited guidance for acute non-ST-segment elevation myocardial infarct...
Association of mRNA COVID-19 vaccination near immune checkpoint inhibitor initiation with outcomes: A real-world analysis.
2636 Background: Prior study showed mRNA COVID-19 vaccines can activate innate and adaptive immune pathways and have been...
Efficacy and safety of HLX43 (anti–PD-L1 ADC) in patients with advanced non–small cell lung cancer.
8512 Background: HLX43 (a PD-L1 ADC) has demonstrated encouraging efficacy with a manageable safety in a phase 1 study. He...
Impact of clonal hematopoiesis on clinical outcomes in patients undergoing CAR T-cell therapy: A systematic review and meta-analysis.
e19011 Background: Clonal hematopoiesis (CH) is characterized by the expansion of hematopoietic cell clones harboring soma...
Characterization of extracolonic cancers in individuals with Lynch syndrome: A Canadian population-based cohort.
e22658 Background: While increased risk of colorectal cancer (CRC) is well established in individuals with Lynch syndrome...
Clinical outcome of Asian and non-Hispanic White patients with colorectal cancer in a NCI-designated cancer center serving a diverse catchment area.
e15710 Background: Traditionally, research on the epidemiology and outcomes in minorities in the United States has primari...
Biologic and clinical implications of HPV genome state variation in oropharyngeal cancers.
6076 Background: HPV integration enhances carcinogenesis by ensuring viral DNA retention and increasing E6/E7 expression....
Adjuvant abemaciclib in pN2-3 patients with HR+/HER2− early breast cancer: Real-world outcomes from Moscow centers.
e12535 Background: Adjuvant abemaciclib (adA) plus endocrine therapy (ET) resulted in a statistically and clinically signi...