Journal of Clinical Oncology
Articles in this Issue
Artificial intelligence (AI)–augmented analysis of quantitative circulating tumor DNA (ctDNA) burden and longitudinal kinetics to identify prognostic risk stratification in metastatic clear cell renal cell carcinoma (mccRCC).
4522 Background: The relevance of ctDNA burden and longitudinal kinetics in RCC remains poorly defined. We applied AI–base...
Role of gallium-68-labeled FAPI-PET imaging in oncology: Results of a study in 310 patients.
e15076 Background: Current oncological PET imaging approaches rely on metabolic targets, primarily 18...
Impact of diabetes mellitus on inpatient outcomes among hospitalized patients with multiple myeloma: A National Inpatient Sample analysis (2018–2020).
e19540 Background: Diabetes mellitus (DM) is common in patients with multiple myeloma (MM). While DM is often perceived as...
Tinengotinib (TT-00420) in advanced/metastatic FGFR2-altered cholangiocarcinoma following prior chemotherapy and FGFR inhibitor treatment: Results from a phase II study (FIRST-08).
4133 Background: Subsequent treatment options for advanced cholangiocarcinoma (CCA) after failure of chemotherapy and FGFR...
Influence of onboard, tethered IL-12 on potency of the Tmod NOT gate and selectivity.
2562 Background: To realize the full therapeutic potential of engineered immune cells in solid tumors, high potency must b...
Evaluating the organizational benefits of remote symptom monitoring during injectable outpatient cancer treatment: The final analysis of the randomized OPTIMACURE trial.
1637 Background: Remote monitoring (RM) to assess whether patients are apt for cancer treatment is already used during sta...
Physician ownership and investment interests in oncology: A national analysis of open payments data (2018-2024).
e23024 Background: Financial relationships between physicians and industry raise concerns about conflicts of interest. The...
Phase IIb randomized trial of FOLFIRINOX plus ibrilatazar (ABTL0812) versus placebo as first-line treatment in metastatic pancreatic cancer: An analysis from the PanC-ASAP study.
4218 Background: Metastatic pancreatic ductal adenocarcinoma (mPDAC) has poor prognosis and limited first-line treatment o...
Tumor-of-origin prediction using methylation signals from plasma cell-free DNA (cfDNA): Real-world experience in Asia and the Middle East (AME).
3051 Background: Accurate identification of tumor tissue of origin (TOO) is essential for guiding treatment decisions in a...
Clinical impact of <i>MSH3</i> loss-of-function alterations in patients treated with immune checkpoint blockade across cancer types.
10516 Background: MSH3 is an alternate mismatch repair protein specialized in the recognition of larger indels through its...
Long-term safety outcomes of pregnancy among young breast cancer survivors: Results from a prospective, multicenter cohort study.
632 Background: Prospective data on the risk of breast cancer (BC) recurrence among young BC survivors who have a subseque...
Efficacy and patient-reported outcome of trophoblast cell surface antigen-2 antibody-drug conjugate in advanced non–small cell lung cancer: An individual patient data survival analysis and meta-analysis.
e20511 Background: Trop-2 ADCs have emerged as a novel therapeutic approach in NSCLC that is refractory to chemotherapy an...
Robot-assisted versus laparoscopic radical nephrectomy for renal tumors in adults: A systematic review and meta-analysis.
e16503 Background: Minimally invasive radical nephrectomy is the standard treatment for renal tumor resection. While lapar...
Comparison by immunotherapy agent of real-world outcomes with chemoimmunotherapy in first-line extensive-stage small cell lung cancer.
8103 Background: Chemoimmunotherapy became the standard of care for extensive-stage small cell lung cancer (ES-SCLC) after...
Prevalence of high-risk human papillomavirus infection in allogeneic stem cell transplant recipients.
e18565 Background: Persistent infection with high-risk human papillomavirus (HR-HPV) is an important cause of malignancy,...
Survival outcomes in melanoma of unknown versus known primary receiving immunotherapy: A systemic review and meta-analysis.
e21500 Background: Historically, patients with melanoma of unknown primary (MUP) had better survival than those wi...
Lymphoma histology as independent predictor of ICU mortality after adjustment for illness severity: A retrospective cohort study of 1,268 patients.
e19106 Background: Lymphomas comprise biologically heterogeneous malignancies ranging from aggressive to indolent subtypes...
A randomized phase II study of capmatinib plus osimertinib with or without ramucirumab in patients with <i>EGFR</i> -mutant, <i>MET</i> -amplified stage IV or recurrent no–small cell lung cancer (Lung-MAP Sub-Study S1900G).
TPS8677 Background: Patients (pts) with advanced EGFR -mutant non-small cell lung...
A phase III placebo controlled randomized controlled trial using combination therapy for treatment-related fatigue in patients with prostate cancer.
12005 Background: To determine if the combination of exercise (EX) plus methylphenidate (MP) is superior to EX plus placeb...
Epidemiology and survival of melanoma in Jordan, 2013-2022: A registry-based study of trends and histologic patterns.
e21542 Background: Melanoma is an aggressive skin malignancy with increasing global incidence and wide geographic variatio...
Evaluating nuclear lamina-associated alterations as predictors of prostate cancer recurrence.
e17119 Background: Prostate cancer exhibits marked disparities, and despite definitive treatment, some men with clinically...
Chronotherapy in metastatic non–small cell lung cancer: Clinical outcomes according to immune checkpoint inhibitor administration time during the day in patients treated with first-line chemoimmunotherapy.
8575 Background: Although circadian rhythms are known to modulate immune cell function, the effect of immune checkpoint in...
An NCDB analysis on the demographic, treatment, and survival of small cell carcinoma with fusiform cells of the lungs.
e20137 Background: Small cell carcinoma with fusiform cells (SCC-FC), commonly originating in the lungs, is clinically cha...
Clinicopathology-based machine learning model for prediction of pathologic complete response to neoadjuvant chemotherapy in breast cancer.
e12567 Background: Pathologic Complete Response (pCR) following neoadjuvant chemotherapy (NAC) is a surrogate for long-ter...
Implementation of a cancer-oriented geriatric assessment (COGA) clinic to promote age-friendly cancer care: A type III hybrid implementation–effectiveness method in community practice.
TPS1681 Background: Cancer incidence increases with age, and adults aged ≥65 years account for the majority of new cancer...