Journal of Clinical Oncology
Articles in this Issue
Thromboembolic events in patients with advanced non-small cell lung cancer receiving palliative chemoimmunotherapy with pembrolizumab.
e24068 Background: Thromboembolic events (TEEs) represent a serious and clinically significant complication in patients (p...
Clinicopathologic features, treatment patterns, and outcomes in young women with metastatic breast cancer: A National Cancer Database analysis.
1115 Background: Young women with metastatic breast cancer (MBC) represent a distinct and understudied population and ofte...
“When I’m translating, I’m a daughter as well”: Perspectives of caregivers supporting patients with limited language proficiency.
12096 Background: Family caregivers of people with advanced cancer provide essential support but often experience signific...
Dose-dependent effect of dinutuximab-IR700 photoimmunotherapy on GD2-expressing tumors.
e14556 Background: Near-infrared photoimmunotherapy (PIT) is a novel, molecularly targeted cancer therapy. It combines tum...
Safety and efficacy of chemotherapy in metastatic colorectal cancer with liver dysfunction due to hepatic metastases: A systematic review.
e15620 Background: Patients with metastatic colorectal cancer (mCRC) and severe hepatic dysfunction from liver metastases...
Enabling hybrid AI–radiologist endpoints in clinical trials imaging workflows.
2019 Background: Imaging endpoints in oncology clinical trials commonly rely on a 2 + 1 radiologist reading paradigm, in w...
Breast cancer mortality among patients with mental and behavioral disorders in the United States: An age-stratified national analysis (1999–2023).
e13091 Background: Breast cancer is the most commonly diagnosed cancer and a leading cause of cancer-related mortality amo...
Neoadjuvant cadonilimab plus CapeOX in patients with clinical stage III gastric or esophagogastric junction adenocarcinoma (GC/EGJC): A prospective, single-arm phase II study.
4089 Background: Perioperative PD-L1 inhibitor plus chemotherapy has shown survival benefit in PD-L1-positive patients wit...
Thalamic neuroepithelial cysts: Endoscopic management strategies and clinical outcomes.
e14046 Background: Thalamic neuroepithelial cysts are rare congenital lesions that can cause significant neurological morb...
Outcomes of neoadjuvant checkpoint inhibitor therapy followed by definitive chemoradiation in locally advanced head and neck squamous cell carcinoma (HNSCC).
e18014 Background: Approximately 70,000 Americans are diagnosed with HNSCC annually. While the KEYNOTE-689 trial establish...
Molecular biomarker testing to predict outcomes in gliomas: A SEER registry study in Kentucky.
e14095 Background: Molecular testing has been required since 2021 for the diagnosis of many primary CNS tumors, and in 201...
Transcriptomic signature of temozolomide treatment-effect heterogeneity in IDH-wildtype glioblastoma.
2084 Background: Adjuvant temozolomide (TMZ) is standard of care for IDH-wildtype glioblastoma (GBM), yet clinical benefit...
The PROFOUND study: A large-scale prospective multicenter case-control trial of a multi-cancer early detection (MCED) test in China.
10541 Background: Early cancer detection reduces morbidity and mortality, but current recommended screening in China misse...
Cabozantinib plus nivolumab (C+N) versus sunitinib (S) in patients with advanced renal cell carcinoma (aRCC) and liver metastasis: Subgroup analysis of the phase 3 CheckMate-9ER trial.
4530 Background: In the phase 3 CheckMate 9ER trial (NCT03141177), C+N treatment significantly improved progression-free s...
From local pixels to global patterns: Vision transformer–based modeling for lung cancer classification on computed tomography.
e20014 Background: Lung cancer remains the leading cause of cancer-related mortality worldwide, driven largely by delayed...
A prospective, single-arm, phase II exploratory clinical study on the efficacy and safety of neoadjuvant adebrelimab combined with cisplatin and docetaxel in patients with clinical stage IVB oral squamous cell carcinoma.
6048 Background: Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck. Stag...
ctDNA clearance durability and progression-free survival in unresectable or metastatic cutaneous malignancies.
9591 Background: Circulating tumor DNA (ctDNA) has emerged as a sensitive biomarker for disease monitoring and prognostica...
Predictors of surgery refusal and disease-specific survival outcomes in inflammatory breast cancer: A nationally representative cohort study.
e12725 Background: Inflammatory breast cancer (IBC) is a rare but highly aggressive subtype of breast cancer characterized...
Demographic and clinical factors impacting survival in malignant pheochromocytoma: A population-based analysis.
e22605 Background: Malignant pheochromocytoma is a rare and potentially aggressive neuroendocrine tumor arising from chrom...
Final results of a phase 2 trial of cabozantinib plus nivolumab (CaboNivo) in patients with non–clear cell renal cell carcinoma (nccRCC).
4521 Background: CaboNivo improved objective response rate (ORR), progression-free survival (PFS), and overall survival (O...
The CNS exile: An AI-driven audit of active brain metastasis exclusions in modern NSCLC immunotherapy clinical trials.
e13746 Background: Up to 50% of patients with metastatic non-small cell lung cancer (NSCLC) will develop brain metastases...
Age-specific trends in liver cancer mortality in the United States, 1999–2023: A Joinpoint regression analysis.
e16334 Background: Liver cancer remains a leading cause of cancer-related mortality in the United States. Although overall...
Rationale and study design of the KOV-HIPEC-04: A phase III randomized controlled trial in primary stage three and four ovarian cancer after interval cytoreductive surgery (FOCUS).
TPS5643 Background: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) during interval cytoreductive surger...
Camrelizumab combined with capecitabine as maintenance therapy for metastatic nasopharyngeal carcinoma: A phase II single-arm clinical trial.
e18016 Background: Metastasis is the main cause of death in nasopharyngeal carcinoma (NPC). The current first-line treatme...
Barriers to comprehensive genomic profiling implementation in Japan and perspectives on systemic reform: A longitudinal analysis of nationwide physician surveys (2019–2025).
e15083 Background: Comprehensive Genomic Profiling (CGP) was reimbursed in Japan in 2019. By 2025, physician awareness rea...