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Comprehensive bioinformatics analysis reveals novel potential biomarkers associated with aging and mitochondria in osteoporosis
6-hydroxygenistein attenuates hypoxia-induced injury via activating Nrf2/HO-1 signaling pathway in PC12 cells
Early detection of autism spectrum disorder: gait deviations and machine learning
Explainable attention based breast tumor segmentation using a combination of UNet, ResNet, DenseNet, and EfficientNet models
Ensemble genetic and CNN model-based image classification by enhancing hyperparameter tuning
Magnetic properties of different phases iron oxide nanoparticles prepared by micro emulsion-hydrothermal method
A survey of Australian dairy farmers’ attitudes to their business, its challenges and transitioning to alternative enterprises
Structural reliability assessment using quartic normal transformation
The effects and predictive values of novel anthropometric parameters on uric acid levels and hyperuricemia in adults
A multi-level analysis of motor and behavioural dynamics in 9-month-old preterm and term-born infants during changing emotional and interactive contexts
AbstractComputational analysis of infant movement has significant potential to reveal markers of developmental health. We report two studies employing dynamic analyses of motor kinematics and motor behaviours, which characterise movement at two levels, in 9-month-old infants. We investigate the effect of preterm birth (< 33 weeks of gestation) and the effect of changing emotional and social-interactive contexts in the still-face paradigm. First, multiscale permutation entropy was employed to analyse acceleration kinematic timeseries data collected from Inertial Measurement Unit (IMU) sensors on infants’ torso, wrists, and ankles (N = 32: 10 term; 22 preterm). Second, Recurrence Quantification Analysis was used to characterise patterns of second-to-second behavioural changes, from observationally coded behavioural timeseries on infants’ emotional self-regulation (N = 111: 61 term; 50 preterm). We found frequency-specific effects of context on permutation entropy. Relative to infants born at term (> 37 weeks of gestation), infants born preterm showed greater permutation entropy in their left ankle and torso movements, but not in right ankle or wrist movements. We did not find effects of preterm birth or emotional context on micro-level behavioural dynamics. Our methodology and findings inform future work using multiscale entropy to study infant development. Dynamic analysis of behaviour is a relatively young field, and applications to emotional self-regulation requires further methodological development.
Rapid climate action is needed: comparing heat vs. COVID-19-related mortality
AbstractThe impacts of climate change on human health are often underestimated or perceived to be in a distant future. Here, we present the projected impacts of climate change in the context of COVID-19, a recent human health catastrophe. We compared projected heat mortality with COVID-19 deaths in 38 cities worldwide and found that in half of these cities, heat-related deaths could exceed annual COVID-19 deaths in less than ten years (at + 3.0 °C increase in global warming relative to preindustrial). In seven of these cities, heat mortality could exceed COVID-19 deaths in less than five years. Our results underscore the crucial need for climate action and for the integration of climate change into public health discourse and policy.
A mouse model of deep vein thrombosis by inferior vena cava hypoperfusion using ameroid constrictors
Unilateral biportal endoscopic decompression combined with percutaneous pedicle screw fixation offers new treatment option for thoracolumbar burst fractures with secondary spinal stenosis
Using electrical resistivity techniques (ERT and SP) for nondestructive detection of seepage channels at the Leitai heritage site, China
Antimicrobial properties of Graphene sheets embedded with Titanium Oxide and Calcium Oxide nanoparticles for industrial wastewater treatment
Possible glendonite mineral pseudomorphs in the aftermath of the end-Permian extinction
AbstractGlendonites (from the precursor of ikaite, CaCO3.6H2O) preferentially precipitate within sediments in cold waters (− 2 to 7°C) via either organotrophic or methanogenic sulphate reduction. Here, we report the first occurrence of possible glendonites associated with the end Permian mass extinction in the earliest Triassic (ca. 252 Million years ago, Ma) subtropical marine carbonates on the Arabian Plateau, Oman. The authigenic carbonate crystals are small (< 2 mm) and precipitated either on bedding planes or reworked within micro cross-laminations, erosional scours, or lags at the base of calcisiltite turbidites, supporting a syn-depositional origin. The observed shape and macrostructure bear resemblance to that of glendonites. SEM and cathodoluminescent imaging reveals unzoned internal structures with three mineral phases: irregular, pseudo-hexagonal and spherical low-Mg calcite crystals (Type 1), low-Mg calcite cement (Type 2), and a later void-filling silica cement (Type 3). The pseudomorphs show δ13C values from − 0.14‰ to − 0.85‰ (mean − 0.43‰; n = 5) that are more positive than the associated micritic matrix, where values range from − 0.92‰ to − 2.39‰ (mean − 1.64‰; n = 7), indicating that oceanic dissolved inorganic carbon (DIC) was the primary carbon source rather than either methane or organic matter. These δ13C values significantly differ from typical δ13C signatures of authentic glendonites, except for Ordovician examples. If these are glendonites, we infer that they could have precipitated due to the unusually elevated alkalinity and pH (> 9) oceanic conditions present in the aftermath of the end-Permian extinction associated with highly disrupted carbon cycle dynamics, possibly accompanied with the upwelling of cold, anoxic oceanic water.
Examining isotonic and isometric exercises for post-activation performance enhancement in kickboxers upper limb strength and power
Sucker rod straightness measurement method based on probability statistics of edge point detection
Use of inpatient palliative care in metastatic testicular cancer patients undergoing critical care therapy: insights from the national inpatient sample
AbstractTo test for rates of inpatient palliative care (IPC) in metastatic testicular cancer patients receiving critical care therapy (CCT). Within the Nationwide Inpatient Sample (NIS) database (2008–2019), we tabulated IPC rates in metastatic testicular cancer patients receiving CCT, namely invasive mechanical ventilation (IMV), percutaneous endoscopic gastrostomy tube (PEG), dialysis for acute kidney failure (AKF), total parenteral nutrition (TPN) or tracheostomy. Univariable and multivariable logistic regression models addressing IPC were fitted. Of 420 metastatic testicular cancer patients undergoing CCT, 70 (17%) received IPC. Between 2008 and 2019, the rates of IPC among metastatic testicular cancer patients undergoing CCT increased from 5 to 19%, with the highest rate of 30% in 2018 (EAPC: + 9.5%; 95% CI + 4.7 to + 15.2%; p = 0.005). IPC patients were older (35 vs. 31 years, p = 0.01), more frequently had do not resuscitate (DNR) status (34 vs. 4%, p < 0.001), more frequently exhibited brain metastases (29 vs. 17%, p = 0.03), were more frequently treated with IMV (76 vs. 53%, p < 0.001) and exhibited higher rate of inpatient mortality (74 vs. 29%, p < 0.001). In multivariable analyses, DNR status (OR 10.23, p < 0.001) and African American race/ethnicity (OR 4.69, p = 0.003) were identified as independent predictors of higher IPC use. We observed a significant increase in rates of IPC use in metastatic testicular cancer patients receiving CCT, rising from 5 to 19% between 2008 and 2019. However, this rates remain lower compared to metastatic lung cancer patients, indicating the need for further awareness among clinicians treating metastatic testicular cancer. The increase in IPC rates for metastatic testicular cancer patients receiving CCT indicates a need for ongoing education and awareness among healthcare providers. This could enhance the integration of IPC in the treatment of advanced cancer, potentially improving quality of life and care outcomes for survivors.