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ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation
Association between the depressive symptom trajectories and all-cause mortality in Chinese middle-aged and elderly adults
Optimization of energy management in Malaysian microgrids using fuzzy logic-based EMS scheduling controller
The association between the healthy lifestyle index and MRI-derived body composition measurements in the UK Biobank study
Fear of progression, coping strategies, and associated factors among a sample of Malaysian women with breast cancer
Details on the transport of European eel larvae through the Strait of Gibraltar into the Mediterranean Sea
AbstractNumbers of European glass eels (Anguilla anguilla) monitored along the Atlantic and Mediterranean coasts of Europe currently serve as the main stock indicator in assessment of this critically endangered species. Spawning, however, takes place exclusively in the Sargasso Sea, several thousand kilometers away. The beginning of its complex lifecycle is characterized by a distant and lengthy larval drift, before the young-of-the-year reach the monitoring stations at the European coasts. The oceanic mechanisms regulating dispersal and distribution of European eel leptocephalus larvae, before they metamorphose into glass eels and colonize future growth habitats, are still poorly understood and data are scarce. Here, we present oceanographic and leptocephalus catch data from a 24-h station on board of the German Research Vessel Meteor, covering one event cycle of the tide-derived change of hydrographic conditions in the central part of the Strait of Gibraltar. Results of this study provide detailed insights on how the exchange of water masses between the Atlantic and the Mediterranean Sea may favor or prevent transport and migration of eel larvae through the Strait, which potentially plays a decisive role in timing and magnitude of larval recruitment events into the entire Mediterranean region.
Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells
Isolation and characterization of a new Leptobacillium species promoting tomato plant growth
An effective vessel segmentation method using SLOA-HGC
A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients
Research on design and control method of active vibration isolation system based on piezoelectric Stewart platform
AbstractSpace payloads in orbit are vulnerable to small vibrations from satellite platforms, which can degrade their performance. Traditional methods typically involve installing a passive vibration isolation system between the platform and the payload. However, such systems are usually effective only for high-frequency, large-amplitude vibrations and perform poorly in isolating low-frequency vibrations and resonances below 10 Hz. To address this limitation, this paper proposes an active vibration isolation system using a 6-degrees-of-freedom Stewart platform driven by piezoelectric actuators. First, the characteristics of the Stewart platform are analyzed and modeled, with the deformation displacement of each leg calculated through decoupling, allowing for high-precision servo control. Next, given the inherent hysteretic nonlinearity of piezoelectric ceramics, which significantly affects positioning accuracy, the hysteresis mechanism of the actuators is analyzed, and a phenomenological mathematical model based on Bouc–Wen operators is established. A Modified particle swarm optimization (MPSO) method is proposed for identifying the model’s nonlinear parameters, significantly enhancing the optimization efficiency. Finally, feedforward inverse compensation and feedback linearization methods are introduced. Experimental results verify that the designed active–passive vibration isolation system greatly improves both the positioning accuracy of the piezoelectric actuators and the active vibration isolation performance of the platform.
Development and validation of a nomogram to predict survival in septic patients with heart failure in the intensive care unit
Effect of air temperature in indoor transition spaces on the thermal response of occupant during summer
Traffic classification in SDN-based IoT network using two-level fused network with self-adaptive manta ray foraging
Effect of DLPFC rTMS on anhedonia and alpha asymmetry in depressed patients
SMYD3 drives cell cycle and epithelial-mesenchymal transition pathways through dual gene transcriptional repression and activation in HPV-negative head and neck cancer
AbstractHuman papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type in the world and is associated with an overall poor prognosis. The protein methyltransferase SET and MYND domain-containing 3 (SMYD3), which trimethylates H3K4, activates gene transcription and enhances several oncogenic pathways, including epithelial-mesenchymal transition and cell cycle related pathways, in various cancer types. It was also recently shown that SMYD3 is overexpressed in HPV-negative HNSCC, and represses the expression of type I IFN response genes, contributing to resistance to anti-PD-1 checkpoint blockade in this disease. In this study, we show that SMYD3 depletion using siRNA interference or CRISPR decreases cellular proliferation and clonal capacity, induces cell cycle arrest and decreases the invasive potential of HPV-negative HNSCC cell lines. Accordingly, xenografts of SMYD3 knockout tumors derived from a human HPV-negative HNSCC cell line grew significantly slower compared to control tumors in mice. Genome-wide mapping for SMYD3 and H3K4me3 in HPV-negative HNSCC cells using cleavage under targets and release using nuclease (CUT&RUN) assays identified direct downstream gene targets regulated by SMYD3, including cell cycle- and EMT-promoting genes. This study provides insights into the epigenetic role of SMYD3 as an oncogene in HPV-negative HNSCC and supports SMYD3 as a rational therapeutic target in HPV-negative HNSCC.
Polycystic ovary syndrome negatively affects sexual function and lower urinary tract symptoms in syrian women: a case-control study
Abstract Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age worldwide, and its related features like obesity, mental health issues and hyperandrogenism may contribute to inadequately investigated health problems such as sexual dysfunction (SD) and lower urinary tract symptoms (LUTS). Therefore, this study examined the impact of PCOS on sexual function (SF) and lower urinary tract in Syrian women by recruiting a total of 178 women of reproductive age, of whom 88 were diagnosed with PCOS according to the Rotterdam criteria and 90 without PCOS were considered as the control group. Female sexual function index (FSFI) and Bristol Female Lower Urinary Tract Symptom Questionnaire (BFLUTS) were used to assess SF and LUTS respectively. PCOS group had higher SD prevalence compared to control group (65.9% vs 48.9%, p = 0.016), and BMI showed an inverse correlation with the total FSFI score in PCOS group ( p = 0.027, r = -0.235). Furthermore, PCOS group exhibited significantly lower scores in orgasm and satisfaction subdomains. Additionally, PCOS patients had significantly higher total BFLUTS score compared to control group (median 8 vs 5, p = 0.025). Thus, PCOS may be related to SD and LUTS, highlighting the importance of evaluating SF and urinary symptoms in PCOS patients.
Assessment of the potential and application of Be12O12 nanocage for removal of ciprofloxacin from water employing density functional theory
Soil fluoride enrichment process and the possible adaptation prevention principle in coal-burning fluorosis area in Southwest China
AbstractCoal-burning fluorosis prevails in southwest China and other provinces. Although clay used as binder of briquettes was proven to cause coal-burning fluorosis, its enrichment processes remain unknown. The soils and rocks on typical geological units were sampled and simulation experiments were performed to detect the forming process of high-fluoride clay. The surface and mineral soils, farmland soils and rocks have fluoride levels of 157.9–1076.76, 334.58–1419.28, 227.52–1303.11 and 46.05–964.11 mg/kg respectively. Fluoride levels of surface soils, mineral horizon soils and farmland soils are significantly positively correlated, while those between soils and rocks are not significantly correlated. The soils overlying carbonates have substantially higher fluoride levels than those overlying non-carbonates although the carbonates have extremely lower fluoride levels. The fluoride levels in acid insoluble substances are significantly positively correlated with soil fluoride levels. The acid insoluble substances in carbonates have obviously higher fluoride levels than those in non-carbonates. High Ca(Mg) levels in carbonates restrict fluorine leaching into the water and facilitate fluorine deposition in soils. Fluoride enriches in soils with numerous Ca(Mg)CO3 leaching during carbonate weathering, which is a new insight into the cause of high-fluoride clay. An exposure pathway of fluoride is forwarded. The best prevention principle and policy are proposed.