Browse Articles

Subclonal response heterogeneity to define cancer organoid therapeutic sensitivity

Differences in the insulin counterregulatory hormones between obese and nonobese male patients with type 2 diabetes mellitus

Long-awaited ape genomes give new insights into their evolution — and ours

The impact of biological variables on cell kinetics and differentiation dynamics in the mouse incisor epithelium

Trend analysis of antidepressant consumption in Italy from 2008 to 2022 in a public health perspective

Establishment and validation survival prediction models for T1 locally advanced breast cancer after breast conservation surgery versus mastectomy

A prospective study using questionnaires and urodynamic assessments to evaluate bladder function and continence changes after robotic assisted radical prostatectomy

Investigating the impact of glycated hemoglobin levels on stroke severity in patients with acute ischemic stroke

Unlocking the secrets of sleep

Psychological distress in health care workers during the beginning, the middle, and the last part of the COVID-19 pandemic

Responses of the physiological characteristics and endophytic bacteria of Urtica cannabina to simulated drought stress

Novel deep learning algorithm based MRI radiomics for predicting lymph node metastases in rectal cancer

Isotopic data reveal a localist Roman population in late Roman Albintimilium, Liguria

Abstract This study investigates human diet and mobility to understand the socio-economic organisation of a Late Roman community in Liguria, a transitional region between Italy and Gaul, during the 3rd–5th century CE. By combining archaeological, historical, osteological, and isotopic data with novel Bayesian modelling of multi-isotope data (collagen δ13C, δ15N, bioapatite 87Sr/86Sr) from human and animal skeletal remains, as well as modern plant samples, we provide new insights into this hitherto under-researched region. Our findings suggest the community followed a C3-based diet, heavily reliant on plant resources and carbohydrates, supplemented by animal protein, likely from omnivorous pigs. This characteristically Roman diet contrasts with ancient written sources that claimed Ligurians had a “barbarian” diet and lifestyle. We also identified significant sex-based dietary differences, with men consuming more animal-derived protein than women, reflecting traditional Graeco-Roman societal ideals. Although the overall dietary pattern aligns with Roman norms, there is no isotopic evidence of long-distance migration or consumption of significant amounts of imported food. This indicates that the community may have been more localist, prioritising locally available resources over long-distance imports, which is unexpected given the prevalent idea of a large-scale interconnected food network within the Roman Empire.

Platelet miRNAs as early biomarkers for progression of idiopathic REM sleep behavior disorder to a synucleinopathy

The impact of exogenous Oxytocin on visual cortex plasticity across different stages of visual development

Integrative analysis of ceRNA networks and immune cell infiltration in thyroid cancer for enhanced diagnostic and prognostic insights

Daily briefing: Tonka bean trees survive lightning strikes that kill their competitors

Damage mechanism and evolution model of geopolymer stabilized coarse grained fillings subjected to repeated freeze-thaw actions

Exploring the feasibility and effectiveness of a naturalistic family centered intervention to enhance early interactions in toddlers with Down syndrome

Abstract This study analyses the feasibility and effectiveness of BabyMICARE, a manualised intervention programme aimed at improving the interactions between caregivers and infants and toddlers with Down syndrome. The programme’s goal is to enhance caregivers’ sensitivity and reduce directivity during early interactions, particularly during play and daily routines. A pre-test and post-test design was used with 40 dyads of infants with Down syndrome and their caregivers, who were divided into a control group (n = 20) and an intervention group (n = 20), based on baseline scores in key interaction subscales. Sessions were conducted over 10 weeks by trained psychologists. Parent-infant interaction was assessed using the MACI coding system, which measures aspects such as sensitive responsiveness, directivity and the level of reciprocity between the parent and the child. The programme showed high feasibility, with a 100% attendance rate but some rescheduling. Caregivers evaluated it positively. The intervention group demonstrated significant improvements in five of eight MACI scales, particularly in sensitive responsiveness and nondirectiveness, while no changes were observed in the control group. The results suggest that BabyMICARE is a feasible and effective intervention for promoting more responsive, less directive interactions, which may be crucial in fostering children’s development.

Selection of alfalfa water and nitrogen management regimes based on the DSSAT model