Browse Articles
Discover research articles across all indexed journals
Metabolic dysfunction in mice with adipocyte-specific ablation of the adenosine A2A receptor
FDA approves first HER2 × HER3 bispecific antibody
Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study
Acidic pH of early endosomes governs SARS-CoV-2 transport in host cells
A spatiotemporal distribution prediction model for electric vehicles charging load in transportation power coupled network
Human calpain-3 and its structural plasticity: Dissociation of a homohexamer into dimers on binding titin
Tracking metal pollution from illegal gold mining: a health risk assessment in Edfu, Egypt
Abstract Over the past decade, there has been an increase in small-scale gold mining in the arid southern region of Egypt. Miners extract ore from the Eastern Desert and transport it to Nile Valley farms, where ample water facilitates the processing. In Edfu, Egypt, the lack of economic opportunities prompted resource-constrained farmers to transform their agricultural lands into gold mines. The study utilized a multifaceted approach that integrated various methodologies, including remote sensing technologies, field surveys, chemical analyses, and statistical methods. The study aimed to assess the concentrations of carcinogenic agents and determine the potential human health risks associated with these agents in soil and fish samples collected within the city boundaries. The study examined correlations between various heavy metals (HMs), such as Ni, Pb, Cd, Cr, Cu, and Hg, in Soilsamples collected in 2020 and 2022. The results revealed direct proportional relationships among specific HMs. The Index of Geoaccumulation (Igeo) and Pollution Load Index (PLI) revealed significantly elevated values in both years, indicating potential environmental degradation. Although no carcinogenic hazards were identified, non-carcinogenic risks related to ingestion were observed for both adults and children exposed to mercury (Hg), copper (Cu), and arsenic (As). Contamination Factor (CF) values were also significantly high. Ecological risks were observed in both Soiland water, as well as in Nile Tilapia samples. Hazard Quotients (HQ) calculated for Nile Tilapia indicated potential risks for both adults and children, particularly associated with elevated arsenic (As) levels. This transformation elicited concerns regarding environmental and health implications, leading us to undertake a thorough investigation.
Regulation of sod1 mRNA and protein abundance by zinc in fission yeast is dependent on the CCR4-NOT complex
The effectiveness of orthodontic treatment with clear aligners in different thicknesses
Bending stiffness of Toxoplasma gondii actin filaments
Harnessing the biology of regulatory T cells to treat disease
Insights into neuromyelitis optica spectrum disorder and pregnancy from a single-center study in Thailand
CBX2 promotes cervical cancer cell proliferation and resistance to DNA-damaging treatment via maintaining cancer stemness
Migratory behaviour of humpback whales in the southeastern Pacific under climate change
Replisomal coupling between the α-pol III core and the τ-subunit of the clamp loader complex (CLC) are essential for genomic integrity in Escherichia coli
Alpha synuclein overexpression can drive microbiome dysbiosis in mice
Abstract Growing evidence indicates that persons with Parkinson disease (PD), have a unique composition of indigenous gut microbes. Given the long prodromal or pre-diagnosed period, longitudinal studies of the human and rodent gut microbiome before symptomatic onset and for the duration of the disease are currently lacking. PD is partially characterized by the accumulation of the protein α-synuclein (α-syn) into insoluble aggregates, in both the central and enteric nervous systems. As such, several experimental rodent and non-human primate models of α-syn overexpression recapitulate some of the hallmark pathophysiologies of PD. These animal models provide an opportunity to assess how the gut microbiome changes with age under disease-relevant conditions. Here, we used a transgenic mouse strain, which overexpress wild-type human α-syn to test how the gut microbiome composition responds in this model of PD pathology during aging. Using shotgun metagenomics, we find significant, age and genotype-dependent bacterial taxa whose abundance becomes altered with age. We reveal that α-syn overexpression can drive alterations to the gut microbiome composition and suggest that it limits diversity through age. Taxa that were most affected by genotype-age interaction were Lactobacillus and Bifidobacteria . In a mouse model, we showed direct link between alpha synuclein geneotype (hallmark of PD), a dysbiotic and low-diversity gut microbiome, and dysbiotic levels of Bifidobacteria and Lactobacillus (most robust features of PD microbiome). Given emerging data on the potential contributions of the gut microbiome to PD pathologies, our data provide an experimental foundation to understand how the PD-associated microbiome may arise as a trigger or co-pathology to disease.