Browse Articles

Targeting the mitotic kinase NEK2 enhances CDK4/6 inhibitor efficacy by potentiating genome instability

Journal of Biological Chemistry Jessica R. Bobbitt, Leslie Cuellar-Vite, Kristen L. Weber-Bonk et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2025.108196

Outlook for medicines development and use in 2025

Nature Reviews Drug Discovery Sarah Rickwood, Helena Bayley, Stefan Lutzmayer et al. Feb 01, 2025 DOI: 10.1038/d41573-025-00012-2

Integrative computational analysis of anti-influenza potential in Caesalpinia mimosoides Lamk hydroethanolic extract

Scientific Reports Anuwatchakij Klamrak, Shaikh Shahinur Rahman, Napapuch Nopkuesuk et al. Feb 01, 2025 DOI: 10.1038/s41598-025-87585-5

Recent advances in the synthesis and application of biomolecular condensates

Journal of Biological Chemistry Zhongyue Li, Wei Tan, Guo-ping Zhao et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2025.108188

In-situ observation of nanoscale transformations in dehydrating lizardite

Scientific Reports Mutian Qin, Huilin Xing, Jianchao Wang et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88077-2

Imaging-based quantitative assessment of biomolecular condensates in vitro and in cells

Journal of Biological Chemistry Tessa Bergsma, Anton Steen, Julia L. Kamenz et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2024.108130

DLL3 draws two antibody–drug conjugate deals

Nature Reviews Drug Discovery Asher Mullard Feb 01, 2025 DOI: 10.1038/d41573-025-00011-3

Ningxiang pig-derived Lactobacillus reuteri improves the gut health of weaned piglets by regulating intestinal barrier function and cytokine profiles

Scientific Reports Qian Xie, Mei Yang, Qing Duanmu et al. Feb 01, 2025 DOI: 10.1038/s41598-025-87105-5

Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament

Journal of Biological Chemistry Felipe Montecinos, Elif Eren, Norman R. Watts et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2024.108132

Targeting inherited mutations to prevent metastasis

Nature Reviews Drug Discovery M. Teresa Villanueva Feb 01, 2025 DOI: 10.1038/d41573-025-00009-x

Enhancing maize seed resistance to chilling stress through seed germination and surface morphological changes using high voltage electrostatic field

Scientific Reports Yao Lu, Yaoyao Li, Qian Peng et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88346-0

Laser-capture microdissection for spatial transcriptomics of immunohistochemically detected neurons

Journal of Biological Chemistry Balázs Göcz, Éva Rumpler, Soma Szentkirályi-Tóth et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2024.108150

FDA approves next-generation triple therapy for cystic fibrosis

Nature Reviews Drug Discovery Asher Mullard Feb 01, 2025 DOI: 10.1038/d41573-025-00008-y

Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway

Scientific Reports Wei Gu, Mimi Wu, Ruocui Zhang et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88344-2

Inhibition of L-threonine dehydrogenase from Trypanosoma cruzi reduces glycine and acetate production and interferes with parasite growth and viability

Journal of Biological Chemistry Jessica do Nascimento Faria, Amanda G. Eufrásio, Michelle Fagundes et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2024.108080

Cough suppressant reverses lung scarring

Nature Reviews Drug Discovery Sarah Crunkhorn Feb 01, 2025 DOI: 10.1038/d41573-025-00006-0

The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection

Scientific Reports Rongrong Yang, Qianhui Chen, Fangzhou Jiao et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88530-2

Menaquinone-specific turnover by Mycobacterium tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond

Journal of Biological Chemistry Tijn T. van der Velden, Kanwal Kayastha, Caspar Y.J. Waterham et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2024.108094

Sodium channel blocker reduces skin inflammation

Nature Reviews Drug Discovery Sarah Crunkhorn Feb 01, 2025 DOI: 10.1038/d41573-025-00005-1

Investigating the prevalence and associated factors of elevated liver enzymes and dyslipidemia during pregnancy

Scientific Reports Ananya Dutta Mou, Nurshad Ali Feb 01, 2025 DOI: 10.1038/s41598-025-88798-4