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How corporate financialization affects main business performance—Empirical evidence based on a dynamic panel threshold model

Corporate financialization is a growing concern in China, and its impact on the main business of real enterprises is a crucial topic. This paper uses data from all A-share non-financial listed companies in China between 2013 and 2022 to establish a dynamic panel threshold model and test the effect of corporate financialization on enterprise performance. The empirical results indicate a threshold effect between the two variables, corporate financialization has both positive and negative effects on main business performance, with a threshold of 5.82%. Additionally, significant heterogeneous results are found for the nature of ownership, asset maturity, industry and regional distribution.

Artificial neural network with incompressible smoothed particle hydrodynamics for exothermic chemical reaction on heat and mass transfer in a rectangular annulus

Integrative analysis of the metabolome and transcriptome provides insights into the mechanisms of flavonoid biosynthesis in Polygonatum

A noteworthy group of culinary and medicinal plants is Polygonatum species. They are known for their abundant flavonoid compound-rich rhizomes, which have antioxidative and anticancer activities. Using Polygonatum sibiricum Red (SXHZ) and Polygonatum kingianum var. grandifolium (HBES), we conducted transcriptome and metabolomic investigations to look into the molecular processes that control the manufacture of these flavonoids in Polygonatum plants. Seven distinct flavonoid metabolites were identified by the analytical data, with phloretin exhibiting a notable differential expression in the biosynthetic pathway. 30 genes with differential expression were found in both plants after further investigation, five of which are members of the transcription factor family associated with MBW. Thus, we suggest that Phloretin and the genes belonging to the MYB-related transcription factor family play a crucial role in controlling the flavonoid biosynthesis pathway in Polygonatum. This work lays the groundwork for a deeper comprehension of the biosynthesis and metabolic processes of flavonoids in Polygonatum, serving as an invaluable resource for the development of the polygonatum-related pharmaceutical industries as well as for the future breeding of Polygonatum plants with higher flavonoid content.

Sensorimotor adaptation reveals systematic biases in 3D perception

Public knowledge, attitudes, practices, and barriers to skin cancer screening in the United Arab Emirates

Objective To assess knowledge, attitude, practice, and barriers to skin cancer screening among the general population of the United Arab Emirates (UAE). Methods In this cross-sectional study, an online-based questionnaire was distributed via online social media sites such as Facebook, WhatsApp, Twitter, and others to the residents of the UAE. The questionnaire evaluated socio-demographics, knowledge (8 items), attitudes (10 items), practices (14 items), and barriers (9 items) in the context of skin cancer screening. A binary logistic regression was conducted to assess variables associated with practice levels. Results The study included 924 participants (51.9% females), with a median (IQR) age of 32 (22–44) years. Results showed a window for knowledge improvement [median = 4 (3–6) out of a maximum potential score of 8], unfavourable attitudes [median = 37 (33–39) out of a maximum potential score of 50], inadequate practices [median = 41 (31–45) out of a maximum possible score of 70]. The most common barriers to skin cancer screening were lack of knowledge about skin cancer (74.1%), lack of awareness of the need for skin cancer screening (72.2%), and absence of symptoms (54.1%). Older age (OR = 0.985, 95%CI: 0.971–0.998) and lack of health insurance (OR = 0.478, 95%CI: 0.301–0.758) were associated with lower screening practices. Female gender (OR = 1.833, 95%CI: 1.361–2.469), being married (OR = 1.415, 95%CI: 1.006–1.992), being a non-smoker (OR = 1.568, 95%CI: 1.045–2.352) or a former smoker (OR = 2.555, 95% CI: 1.082–6.034), and more favourable attitudes (OR = 1.071, 95%CI: 1.044–1.096) were associated with higher screening practices. Conclusion The UAE population exhibited moderate knowledge, unfavourable attitudes, and inadequate practices regarding skin cancer screening, with several barriers identified. Targeted online and in-person awareness campaigns are crucial for improving public understanding and attitudes, thereby enhancing screening practices, especially among older adults, males, smokers, and those without health insurance.

Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia

The effects of haloperidol on motor vigour and movement fusion during sequential reaching

Reward is a powerful tool to enhance human motor behaviour with previous research showing that during a sequential reaching movement, a monetary incentive leads to increased speed of each movement (motor vigour effect), whilst reward-based performance feedback increases the speed of transition between movements (movement fusion effect). The neurotransmitter dopamine plays a central role in the processing of reward signals and has been implicated to modulate motor vigour and regulate movement fusion. However, in humans, it is unclear if the same dopaminergic mechanism underlies both processes. To address this, we used a complex sequential reaching task in which rewards were based on movement times (MT). Crucially, MTs could be reduced via: 1) enhanced speed of individual movements (motor vigour effect) and/or 2) enhanced speed of transition between movements (movement fusion effect). 95 participants were randomly assigned to a reward or no reward group and were given either 2.5mg of the dopamine antagonist haloperidol or a placebo (control group). An independent decision-making task performed prior to the main experiment suggested that haloperidol was active during the sequential reaching task (positive control). We did not find evidence that haloperidol affected the facilitatory effects of reward on movement fusion. However, we found that haloperidol negated the reward-based effects on motor vigour. Therefore, our results suggest that a D2-antagonist differentially influences reward-based effects on movement vigour and movement fusion, indicating that the dopaminergic mechanisms underlying these two processes may be distinct.

Room temperature CRISPR diagnostics for low-resource settings

Aesthetic evaluation and the perceived properties of Chinese characters

Previous studies have indicated that the visually perceived properties of geometrical figures influence aesthetic evaluations. However, it is unclear whether findings based on geometrical figures can be extended to artworks such as paintings and calligraphy, as artworks have their own contents and meanings. To answer this question, we designed experiments in which users of Chinese characters were asked to rate the perceived symmetry, complexity, prototypicality, and beauty of Chinese characters. Each character was presented to 35 Japanese and Chinese participants in five typing fonts in a laboratory setting (Experiment 1), and to 100 Japanese participants in five calligraphic handwriting scripts online (Experiment 2). By analyzing the relative impacts of perceived properties on aesthetic evaluation and their interactions with script styles using a generalized linear mixed model, we discovered that script style plays an important role in the association between the perceived properties and aesthetic evaluation of Chinese characters. These results are discussed in relation to studies on the aesthetic evaluation of geometrical figures and recent studies using Chinese calligraphy.

Author Correction: Classification of RTV-coated porcelain insulator condition under different profiles and levels of pollution

Goal-line oracles: Exploring accuracy of wisdom of the crowd for football predictions

Football’s inherent volatility and low-scoring nature present unique challenges for predicting outcomes. This study investigates the efficacy of Wisdom of the Crowd in forecasting football match outcomes as well as expected goals (XG) across a Premier League season. Participants predicted team goal counts, which were then compared to actual expected goals (XG) and match results. Results across 760 team predictions reveal that while Wisdom of the Crowd accurately predicts XG on average, it overestimates ’big-6’ teams and underestimates others, hinting at inherent biases. Notably, however, collective crowd predictions outperform individual estimates consistently, affirming the power of collective intelligence. Furthermore, when tested against betting odds, Wisdom of the Crowd demonstrates limited profitability, indicating its potential as a supplementary rather than sole prediction tool. These findings underscore the nuanced dynamics of football prediction and highlight the utility of collective wisdom in navigating its complexities. Overall, this study contributes insights into crowd prediction dynamics and underscores its potential in football analytics, shedding light on its implications for decision-making and understanding group behaviour in sports forecasting contexts.

A comparative analysis of LSTM models aided with attention and squeeze and excitation blocks for activity recognition

The evolution and driving mechanism of education inequality in China: From 2003 to 2020

Although China’s education development has made great progress, there are obvious regional differences in China’s educational development. A systematic investigation of the regional inequality in China’s educational development and its driving factors is of great significance for optimizing the allocation of educational resources and giving full play to the critical role of education in regional development. In addition, the research on the evolution and internal mechanism of educational development inequality in China can also provide experience and reference for the Global South. Therefore, we construct a comprehensive evaluation index system to measure the level of regional educational development, reveal the regional inequalities in China’s educational development, and employ spatial econometric model to dissect the factors influencing the regional inequalities. The results show that China’s educational development level continues to increasing from 2003 to 2020, but a significant decrease in its growth rate. In this process, regional differences in education inequality in China have gradually narrowed, which can be confirmed by changes in the Gini coefficient and Theil index. In terms of direct spillover effects, the per capita fiscal expenditure on education and urbanization rate have positive effects. In terms of indirect spillover effects, per capita GDP and per capita fiscal expenditure on education have negative effects, while population density and urbanization rate have positive effects. After replacing the weight matrix and removing the extreme values, the model also passes the robustness test. However, this mechanism is heterogeneous in different regions, therefore, we put forward the corresponding policies and measures according to the regional driving effects of influencing factors.

Automated strabismus detection and classification using deep learning analysis of facial images

Identification of personal factors that influence engagement in cardiac rehabilitation and interventions targeting personal factors: A scoping review protocol

Cardiac rehabilitation effectively reduces mortality and enhances the quality of life for individuals with cardiovascular disease. Despite that, individuals’ engagement in cardiac rehabilitation remains low. Considering the significant contributions of individuals’ self-management of cardiovascular disease to their progress, it is essential to understand the personal factors that influence engagement in cardiac rehabilitation. This scoping review aims to identify and map personal factors that influence cardiac rehabilitation engagement with a specific focus on the subjective experiential dimensions of personal factors (cognitive, emotional, and behavioural). It also aims to explore interventions targeting personal factors to increase cardiac rehabilitation engagement. This review will be reported using the PRISMA-ScR checklist following the Joanna Briggs Institute (JBI) methodology. It will include peer-reviewed articles published in English from January 2004, excluding grey literature. Studies reporting adult populations aged 18 and over with cardiovascular disease and addressing personal factors or interventions to increase cardiac rehabilitation engagement, will be included. Databases for the searches will include PubMed, Embase, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, Scopus, and Web of Science. The data extraction is developed by the reviewers based on JBI guidelines and relevant literature, the form will detail the characteristics of included publications, personal factors influencing cardiac rehabilitation engagement, and intervention characteristics. The data analysis will summarise descriptively the key features of the included studies and interventions, the Patient Health Engagement Model will guide the categorisation of personal factors into cognitive, emotional, and behavioural aspects, with other personal factors organised as emerging other relevant factors themes. The findings of this review will provide important evidence support for researchers, clinicians and policy makers to promote participation in cardiac rehabilitation. Within the constraints of medical and human resources, attention to personal factors can maximise the individual’s role in cardiac rehabilitation and self-management, contributing to the efficient allocation and use of resources.

Comparative and phylogenetic analyses of the chloroplast genomes of mangrove plants

Computational and In silico study of novel fungicides against combating root rot, gray mold, fusarium wilt, and cereal rust

The exploration of potential candidates for fungicides against four fungal proteins that cause some vital plant diseases, namely Phytophthora capsici, Botrytis cinerea, Fusarium oxysporum f. sp. lycopersici, and Puccinia graminis f. sp. tritici, was conducted using in silico, molecular docking simulations, and molecular dynamic (MD) simulation for selecting the nature of binding affinity with actives sites of proteins. First of all, the DFT was employed to optimize the molecular geometry, and get the prepared optimized ligand. From the DFT data, the chemical descriptors were calculated. Next, two docking tools, such as AutoDock by PyRx and Molecular Docking by Glide from the Schrödinger suite, were used to convey the docking score, and ligand protein interactions against four main proteases, for instance 7VEM, 8H6Q, 8EBB, and 7XDS having name of pathogens: Phytophthora capsici, Botrytis cinerea, Fusarium oxysporum f. sp. lycopersici, and Puccinia graminis f. sp. tritici, respectively. In case of auto dock from PyRx, the fungicides L01, L03, L04, L13, L14, L17, L18, and L19 demonstrated significantly higher affinities for binding to the four fungal pathogens. Surprisingly, it is conveyed that the L03 illustrated the highest binding score against three of 7VEM, 8EBB, and 7XDS proteins and L09 is highest for 8H6Q. However, MD was performed to check the validation and calculation the docking procedure and stability of the protein ligand docked complex accounting of RMSD, RMSF, SASA, Radius of gyration (Rg), Protein secondary structure elements (SSE), Ramachandran plot which confirm that the stability of docked complex is so high, and number of calculating the hydrogen bonds is more than good enough, as a result it is concluded the docking procedure is valid. Finally, Difenoconazole (L03) has been considered as the most promising antifungal drug evaluated from the studies.

Global proteomics and affinity mass spectrometry analysis of human Schwann cells indicates that variation in and loss of neurofibromin (NF1) alters protein expression and cellular and mitochondrial metabolism

The effects of a single bout of high intensity exercise on stress reactivity, mind wandering, and lecture comprehension in young adults

Post-secondary students experience acute stressors daily. Acute stress has been associated with poor cognitive and learning outcomes. Prior work has demonstrated a single bout of exercise can attenuate acute stress responses. The present study examined the effects of a single 30-minute bout of high intensity aerobic exercise on multidimensional stress reactivity and learning-related outcomes. Forty participants were randomized to either engaging in an exercise bout or seated rest. Participants were then exposed to the Trier Social Stress Test followed by a 20-minute video lecture. The video lecture contained embedded mind wandering probes. Acute exercise did not attenuate stress responses, however promoted greater on-task behaviour (i.e., less mind wandering) and improved lecture comprehension scores. Notably, state anxiety was positively associated with mind wandering and mind wandering was negatively associated with lecture comprehension. Collectively, examining the role of acute interventions that reduce state anxiety may promote favourable learning outcomes in young adults.

Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients

Abstract Cell lines derived from circulating tumor cells (CTCs) in the blood provide important biological information on cancer metastasis. CTC-ITB-01 is a CTC cell line derived from a patient with metastatic estrogen receptor-alpha (ER-alpha) positive breast cancer two months before the death of the patient. After a LC-MC/MS based proteomics analysis of CTC-ITB-01, we found extraordinary high levels of the poorly characterized protein SUSD2 (sushi domain-containing protein 2) in CTC-ITB-01. Expression of SUSD2 on subsets of CTCs was validated on clinical blood samples of patients with metastatic breast cancer. SUSD2-positive CTCs could be captured specifically by a MACS-based approach. We overexpressed SUSD2 in the poorly-metastatic cell line MCF-7. This resulted in upregulation of ER-alpha, the tumor progression protein GRP78 (78-kDa glucose-regulated protein) and downregulation of the tumor suppressor protein PDCD4 (programmed cell death protein 4). We observed downregulation of SUSD2 and PDCD4 after hypoxia and simulation of re-oxygenation in the blood in MCF-7 and MDA-MB-468, while in CTC-ITB-01 SUSD2 levels remained unchanged, and only PDCD4 was downregulated under hypoxia. In conclusion, we show, for the first time, that SUSD2 is expressed in CTCs and appears to affect key proteins in tumor progression and survival.