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Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function

The steroid hormone 20-hydroxyecdysone induces lipophagy via the brain-adipose tissue axis by promoting the adipokinetic hormone pathway

GRK5 regulates endocytosis of FPR2 independent of β-arrestins

Effects of mirror-image nucleosides on DNA replication and transcription in human cells

Tau destabilization in a familial deletion mutant K280 accelerates its fibrillization and enhances the seeding effect

HSP90 stabilizes visual cycle retinol dehydrogenase 5 in the endoplasmic reticulum by inhibiting its degradation during autophagy

Conformational transitions of Streptococcus pyogenes Cas9 induced by salt and single-guide RNA binding

P300/RNA polymerase II mediates induction of the teleost viral RNA sensor MDA5 through the interferon regulatory factor IRF11

Diet-induced obesity mediated through estrogen-related receptor α is independent of intestinal function

Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5

Cysteine import via the high-affinity GSH transporter Hgt1 rescues GSH auxotrophy in yeast

New subgenera of Ellipteroides Becker (Tipuloidea: Limoniidae) and their phylogenetic implications

Crucial role and conservation of the three [2Fe-2S] clusters in the human mitochondrial ribosome

Exploring the thermal-induced optical nonlinearity of crude oil via spatial self-phase modulation technique

Inositol phosphates dynamically enhance stability, solubility, and catalytic activity of mTOR

Research on maximum power point tracking of photovoltaic power generation based on improved hybrid optimization algorithm

The cobalamin processing enzyme of Trichoplax adhaerens

The impact of locus of control on somatic and psychological profiles of patients with irritable bowel syndrome engaging in aerobic exercise

Magnesium-dependent-protein phosphatase 1B regulates the protein arginine methyltransferase 5 through the modulation of myosin phosphatase

Changes in optic nerve head microvasculature following disc hemorrhage absorption in glaucomatous eyes

Abstract This study investigated the changes in optic nerve head (ONH) microvasculature, circumpapillary retinal nerve fiber layer (cpRNFL) thickness, and visual field (VF) sensitivity following the absorption of optic disc hemorrhage (DH). Intradisc vessel density (dVD) was calculated using a 3 × 3 mm optic disc scan in 60 eyes of 60 patients with primary open angle glaucoma and DH who had undergone two or more swept-source optical coherence tomography angiography exams. Clinical parameters at the time of DH occurrence and after absorption, as well as those between the subgroups based on DH recurrence and location, were compared. Linear regression analysis was performed to identify factors associated with changes in cpRNFL thickness in the DH-affected quadrant. Mean dVD, cpRNFL thickness, and VF sensitivity significantly decreased after DH absorption (all P < 0.05). The reduction in dVD was more pronounced in eyes with recurrent DH compared to those with a single episode (P = 0.032). Eyes with DH occurring within or at the margin of the disc cup showed a greater dVD reduction than those with DH occurring outside the disc cup (P = 0.049). The reduction in cpRNFL thickness in the DH-affected quadrant correlated with dVD reduction in the same quadrant (β = 0.370, P = 0.013) and DH recurrence (β = -2.617, P = 0.033). This finding suggests that DH pathogenesis may be associated with changes in optic disc vasculature, contributing to glaucomatous progression.