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Selective photoelectrochemical synthesis of adipic acid using single-atom Ir decorated α-Fe2O3 photoanode

Electronic strong coupling modifies the ground-state intermolecular interactions in self-assembled chlorin molecules

Metabolic modeling reveals a multi-level deregulation of host-microbiome metabolic networks in IBD

Abstract Inflammatory bowel diseases (IBDs) are chronic disorders involving dysregulated immune responses. Despite the role of disrupted host-microbial interaction in the pathophysiology of IBD, the underlying metabolic principles are not fully understood. We densely profiled microbiome, transcriptome and metabolome signatures from longitudinal IBD cohorts before and after advanced drug therapy initiation and reconstructed metabolic models of the gut microbiome and the host intestine to study host-microbiome metabolic cross-talk in the context of inflammation. Here, we identified concomitant changes in metabolic activity across data layers involving NAD, amino acid, one-carbon and phospholipid metabolism. In particular on the host level, elevated tryptophan catabolism depleted circulating tryptophan, thereby impairing NAD biosynthesis. Reduced host transamination reactions disrupted nitrogen homeostasis and polyamine/glutathione metabolism. The suppressed one-carbon cycle in patient tissues altered phospholipid profiles due to limited choline availability. Simultaneously, microbiome metabolic shifts in NAD, amino acid and polyamine metabolism exacerbated these host metabolic imbalances. Leveraging host and microbe metabolic models, we predicted dietary interventions remodeling the microbiome to restore metabolic homeostasis, suggesting novel therapeutic strategies for IBD.

Use of de-epithelialized free perforator flaps for simultaneous bone and soft-tissue reconstruction in chronic calcaneus osteomyelitis

The role of human Shu complex in ATP-dependent regulation of RAD51 filaments during homologous recombination–associated DNA damage response

Nrf2-and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice

Bile acids inhibit equilibrative adenosine transport to alter adenosine receptor signaling in cholestasis

Conditional lethality and suppressor analysis of plasmid-based temperature-sensitive fabZ expression in Pseudomonas aeruginosa

Smooth muscle Cxcl12 contributions to vascular remodeling in flow and hypoxia-induced pulmonary hypertension

NOTCH2 disrupts the synovial fibroblast identity and the inflammatory response of epiphyseal chondrocytes

The transcriptional regulator Sin3a activates CD44 and promotes collective luminal breast cancer cell migration

CRAC channel activity pulsates during cytosolic Ca2+ oscillations

High uric acid exacerbates nonalcoholic steatohepatitis through NLRP3 inflammasome and gasdermin D-mediated pyroptosis

The ribonuclease RNase T2 mediates selective autophagy of ribosomes induced by starvation in Saccharomyces cerevisiae

ProOvErlap: Assessing feature proximity/overlap and testing statistical significance from genomic intervals

Evidence of bidirectional transmembrane signaling by the sensor histidine kinase GacS from Pseudomonas aeruginosa

A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function

Circadian clock-independent ultradian rhythms in lipid metabolism in the Drosophila fat body

An uncharacterized gene from the Actinobacillus genus encodes a glucosyltransferase with successive transfer activity and unique substrate specificity

Histone H1 deamidation regulates DNA double-strand break repair