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Uncovering active ingredients and mechanisms of Pholiota adiposa in the treatment of Alzheimer’s disease based on network pharmacology and bioinformatics

Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling

Normalization of elevated preoperative serum creatinine and acute kidney injury after cardiac surgery: a retrospective cohort study

Abstract Preoperative kidney dysfunction is a predictor of acute kidney injury (AKI) following cardiac surgery, limited information exists regarding the impact of preoperative serum creatinine (sCr) change on AKI. This study aims to examine the association between the normalization of elevated preoperative sCr and postoperative AKI, as well as its severity and duration. This retrospective cohort study included patients undergoing open-heart surgery. Patients were categorized into three groups based on preoperative sCr change (ΔScr): the Stable sCr group (maximum ΔScr < 0.3 mg/dL throughout the preoperative period), the Normalized sCr group (maximum ΔScr ≥ 0.3 mg/dL followed by normalization to < 0.3 mg/dL within 48 h pre-surgery), and the Worsened sCr group (maximum ΔScr ≥ 0.3 mg/dL, remaining ≥ 0.3 mg/dL within 48 h pre-surgery). Multivariable logistic regression was used to evaluate the association between preoperative sCr change and postoperative AKI, severe AKI, and persistent AKI. To control for selection bias, propensity score matching (1:3) was used by matching covariates between the Normalized sCr and the Stable sCr group. Of the 560 patients included, 40.2% developed AKI. In the Normalized sCr group, the rate of AKI was 61.2%, severe AKI 22.4%, and persistent AKI 34.7%. Multivariable logistic regression analyses revealed the Normalized group was associated with higher risk of postoperative AKI (adjusted OR, 2.51; 95% CI, 1.30‒4.85, p = 0.006), severe AKI (adjusted OR, 3.40; 95% CI, 1.37–8.45, p = 0.008) and persistent AKI (adjusted OR, 2.87; 95% CI 1.36‒6.05, p = 0.006). After propensity matching, 184 patients were matched (46 in the Normalized sCr group and 138 in the Stable sCr group). The Normalized sCr group were still associated with risk of AKI (adjusted OR, 2.77; 95% CI, 1.34–5.73, p = 0.006), severe AKI (adjusted OR, 4.10; 95% CI, 1.32–12.71, p = 0.015) and persistent AKI (adjusted OR, 2.72; 95% CI, 1.21–6.15, p = 0.016). Normalization of preoperative sCr following an initial elevation was associated with higher risks of AKI, as well as AKI severity and duration.

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Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation

Integrated bioinformatics and experimental validation identify lysosome and immune infiltration-related genes as therapeutic targets in late-onset major depressive disorder

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Drug induced liver injury in HIV patients on dolutegravir based antiretroviral therapy regimens in Wolaita Sodo comprehensive specialized hospital

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Design and analysis of a power transmission system for 55 kW electric tractor using agricultural workload data

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Potent antimicrobial and antibiofilm activity of citric acid coated magnetite nanoparticles for leather preservation

Measurable Residual Disease–Guided Therapy in Newly Diagnosed Myeloma