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Identification of novel human IgE-binding peptides from a phage display library for total IgE detection
Protective effects of avocado peel and seed extracts against UVB-damaged fibroblasts for the development of an anti-photoaging nanoemulgel
Abstract This study investigates the anti-photoaging potential of ethanolic extracts from avocado peel and seed and their application in a nanoemulgel formulation. Both extracts demonstrated high phenolic content and strong antioxidant activity, with DPPH IC50 values of 57.05 ± 1.65 µg/ml (peel) and 52.44 ± 0.32 µg/ml (seed). In UVB-irradiated human dermal fibroblasts (BJ cells), the extracts (12.5–50 µg/ml) significantly reduced intracellular ROS, decreased MMP-1 and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), and restored collagen levels. A nanoemulgel was developed using the phase inversion composition (PIC) method, with avocado oil, isononyl isononanoate, Tween 60, and polyglyceryl-3 diisostearate, which resulted in nanoemulsions (NEs) with an average droplet size of 84.45 ± 5.45 nm and a zeta potential of −69.94 ± 5.66 mV. Incorporation of 0.5% Aqupec HV-505E and avocado extracts produced stable, light green gel. The resulting avocado extract-loaded nanoemulgel (ANE) demonstrated antioxidant activity, cytocompatibility with BJ cells, and stability in terms of color, pH, and viscosity. These findings reveal the anti-aging potential of avocado peel and seed extracts in preserving effectiveness within nanoemulgel for skin applications.
Biphasic liquids with shape-shifting and bistable microdomains
A real-time predictive postural control system with temperature feedback
Design and characterization of multiwall carbon nanotube/polydimethylsiloxane composite MIMO antenna for wearable and vehicular applications
An efficient fusion detector for road defect detection
Dynamic kinetic resolution of phosphines with chiral supporting electrolytes
The impact of China’s super urban agglomeration strategy on industrial pollution
Author Correction: BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans
Advanced polynomial Y-function method for precise mobility characterization in 2D FETs
Factors associated with health-related quality of life and financial toxicity among gynecological cancer patients in Southern Nigeria
Abstract The health-related quality of life (HRQoL) and financial toxicity (FT) of women with gynecological cancers in sub-Saharan Africa have not been sufficiently explored. This study assessed predictors of HRQoL and FT, as well as the effect of FT on HRQoL, among affected women in Nigeria. This cross-sectional study investigated 574 women with gynecological cancers receiving care at various stages at five academic hospitals in southern Nigeria between June 2022 and September 2024. HRQoL and FT were evaluated using the FACT-G and FACIT-COST tools, respectively. Multivariable linear regression models estimated the associations of patient characteristics with HRQoL and FT and the effect of FT on HRQoL. Most women experienced FT. After multivariable adjustments, unemployed women, women with ovarian and uterine cancers and choriocarcinoma, higher disease stages, and worse ECOG status had worse HRQoL. Conversely, women in remission had better HRQoL. FT was worse with stages III and IV disease and in those on active treatment. However, older women, those with health insurance, higher income, ovarian cancer and choriocarcinoma had better FT. FT varied linearly with HRQoL, with better HRQoL per unit better FT. This effect was stronger in those with a first tumor, those in pre-treatment and those in remission. Our findings identify possible predictors of HRQoL and FT and suggest potential benefits of reducing FT on the HRQoL of women with gynecological cancers in Nigeria.
Effect of emotion on hawk-dove game for two players with different strength
Higher legs muscle mass reduces gross mechanical efficiency during moderate intensity cycling in young healthy men
A variant form of receptor activator of nuclear factor-κB functions as an osteoprotegerin mimic in bone and cardiac development
Methodology and pilot implementation of modular educational-development platform for Interoperable Digital Twin
Assessment of groundwater quality and potential health risks related to heavy metals in a peri-urban area of a developing country
Mechanism of cytarabine-induced neurotoxicity
NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA
Numerical simulation and optimization of FTO/TiO2/CZTS/CuO/Au solar cell using SCAPS-1D
Abstract Kesterite materials, especially copper zinc tin sulphide (CZTS), have emerged as very promising solar cell materials because of their sustainability, cost-effectiveness, and environmentally friendly composition. CZTS, composed of abundant and nontoxic elements, stands as a leading candidate among materials for efficient, sustainable, and cost-effective photovoltaic technologies. The " FTO/TiO2/CZTS/CuO/Au " solar cell has been simulated using SCAPS-1D, where FTO is the front contact, TiO2 is the electron transport layer, CZTS is the absorber layer, CuO is the hole transport layer and Au is the back contact, this device presenting an investigation of the structure, material properties, and carrier dynamics of such a device under standard AM 1.5 G illumination at 300 K. By defining characteristics of the layers, such as thickness, band gap, doping concentrations, and mobility, the software gives insight into photovoltaic performance with main results concerning J-V curves, quantum efficiency, and energy band diagrams. The maximum simulated efficiency achieved is 33.56% by optimising different parameters such as thickness, carrier concentration, and band gap.