Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease

L Louise A. Hyslop (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) E Emma L. Blakely (NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom) M Magomet Aushev (Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Biomedicine West Wing, Centre for Life, Newcastle upon Tyne, United Kingdom) J Jordan Marley (Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Biomedicine West Wing, Centre for Life, Newcastle upon Tyne, United Kingdom) Y Yuko Takeda (Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Biomedicine West Wing, Centre for Life, Newcastle upon Tyne, United Kingdom) A Angela Pyle (Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom) E Eilis Moody (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) C Catherine Feeney (NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom) J Jan Dutton (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) C Carol Shaw (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) S Sarah J. Smith (NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom) K Kate Craig (NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom) C Charlotte L. Alston (NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom) L Lisa Lister (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) K Karina Endacott (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) S Samantha Byerley (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) H Helen McDermott (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) K Kathryn Wilson (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) L Lynne Botham (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) B Beth Matthew (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) N Nilendran Prathalingam (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) M Matthew Prior (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) A Alison Murdoch (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) D Douglass M. Turnbull (Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom) G Gavin Hudson (Mitochondrial Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom) M Meenakshi Choudhary R Robert W. Taylor (Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom) R Rekha N. Pillai (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) J Jane A. Stewart (Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom) R Robert McFarland (Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom) M Mary Herbert

Article Details

Volume / Issue Vol. 393, Issue 5
Published July 31, 2025
Pages 438-449
ISSN 0028-4793
Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (31)

L

Louise A. Hyslop

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

E

Emma L. Blakely

NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

M

Magomet Aushev

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Biomedicine West Wing, Centre for Life, Newcastle upon Tyne, United Kingdom

J

Jordan Marley

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Biomedicine West Wing, Centre for Life, Newcastle upon Tyne, United Kingdom

Y

Yuko Takeda

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Biomedicine West Wing, Centre for Life, Newcastle upon Tyne, United Kingdom

A

Angela Pyle

Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

E

Eilis Moody

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

C

Catherine Feeney

NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

J

Jan Dutton

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

C

Carol Shaw

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

S

Sarah J. Smith

NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

K

Kate Craig

NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

C

Charlotte L. Alston

NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

L

Lisa Lister

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

K

Karina Endacott

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

S

Samantha Byerley

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

H

Helen McDermott

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

K

Kathryn Wilson

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

L

Lynne Botham

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

B

Beth Matthew

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

N

Nilendran Prathalingam

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

M

Matthew Prior

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

A

Alison Murdoch

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

D

Douglass M. Turnbull

Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

G

Gavin Hudson

Mitochondrial Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

M

Meenakshi Choudhary

R

Robert W. Taylor

Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

R

Rekha N. Pillai

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

J

Jane A. Stewart

Newcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, International Centre for Life, Newcastle upon Tyne, United Kingdom

R

Robert McFarland

Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

M

Mary Herbert