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A Language model-based approach to sentiment classification of languages in central Asia
Mild hypoxia adversely impacts human vestibular function
Machine learning-enabled acoustic sensing for RPW infestation detection
The influence of the ratio between Li2O and B2O3 on optical, luminescence, and thermal properties of samarium-doped lithium borate glass
Correction: Blockchain-integrated IoT device for advanced inspection of casting defects
Lexical priming of space depends on how deeply you think about it
Bayesian model averaging based deep learning forecasts of inpatient bed occupancy in mental health facilities
Decreased expression of BCL2 protein on the diagnostic bone marrow T cells in adult acute myeloid leukemia
Enhanced stratification of male pattern hair loss using AI through novel loss region ratio analysis
Microglial activation drives neuronal dysregulation in alcohol-induced seizure susceptibility
Oral niacin mitigates heat-induced reproductive impairments in male mice
Study on the influence of overlying coal seam mining on the deformation of floor roadway surrounding rock
Abstract The roadway is the lifeline of the underground production system of the coal mine. Once deformation and damage occur, it can easily lead to mining disasters. After the coal seam is mined, the distribution of the original stress field is changed, and a new mining stress field is generated, which causes the surrounding rock of the roadway at the bottom of the coal seam to be affected to varying degrees. This paper takes the Lu Ling coal mine in China as the research object, and uses the method of combining similarity simulation test and numerical simulation to study the surrounding stress and deformation damage of the floor roadway with the mining of the main coal seam in Luling Coal Mine. The results show that under the action of tectonic stress, with the mining of the overlying main coal seam, the stress concentration and plastic damage of the roof and floor of the roadway in the coal seam floor are relatively small, while the pressure relief and plastic damage of the two sides are relatively large in Luling Coal Mine. To verify the influence of different mining dynamic stresses on the deformation and damage of roadway, mining simulations were conducted under both structural stress and self weight stress conditions. The results showed that the collapse shape of the roof was significantly different under different stress fields, and the stress evolution law of the mining floor was also different. Under the main control of structural stress, the total body of the floor was mainly under compressive stress, while under the main control of self weight stress, it was significantly affected by the unloading of the overlying goaf, mainly under tensile stress, resulting in significantly different forms of roadway failure. This study can provide a reference for analyzing the surrounding rock stability of all-mudstone roadways in mines under different in-situ stress conditions.
Modified exosomes for targeted delivery of doxorubicin and carvedilol to mitochondria in breast cancer cells
Abstract Carvedilol (CAR), a well-established β-blocker and a promising pharmacological agent for mitigating doxorubicin (DOX)-induced cardiotoxicity, has also demonstrated anticancer effects against breast cancer cells. Given the seemingly contradictory effects of CAR and DOX treatment on cardiomyocytes and cancer cells, particularly regarding mitochondrial function, this study investigates the synergistic potential of DOX and CAR through various delivery systems, including free form, exosomal formulations, and mitochondria-targeted delivery systems. The Chou-Talalay analysis demonstrated that combining DOX with CAR at a 1:1 ratio reduced DOX’s IC50 in MCF-7 (from 0.274 µM to 0.191 µM) and MDA-MB-231 (from 0.138 µM to 0.086 µM) cells. Drug loading in exosomal formulations was achieved with approximately 24% efficiency, maintaining the optimum ratio. While CAR exhibited minimal cytotoxicity at concentrations below 2 µM, its combination with DOX enhanced anticancer effects. Mitochondrial-targeted delivery (TPP-Exo-DOX-CAR) showed reduced cytotoxicity compared to TPP-Exo-DOX formulation. ROS production analysis and mitochondrial membrane potential assessments revealed that CAR’s protective effects become dominant in mitochondria-targeted delivery in vitro. Migration studies demonstrated significant inhibition of cell motility in CAR containing formulations. These findings suggest that while the DOX and CAR combination shows promise in cancer treatment, the delivery system significantly impacts their therapeutic efficacy, particularly in mitochondrial-targeted applications.
Comparative antimicrobial activity of Zataria multiflora essential oil nanoformulations against foodborne pathogens
Abstract Foodborne diseases caused by microbial contamination, as a profound global health challenge, driving the search for natural antimicrobial compound. This study investigated the antimicrobial potential of Zataria multiflora essential oil ( Z. multiflora EO) encapsulated in alginate nanoparticles (Alg-EO), chitosan nanoparticles (Chi-EO), and nanoemulsions (NE-EO) against major foodborne pathogens: Escherichia coli ( E. coli ), Salmonella Typhimurium ( S. Typhimurium ), Pseudomonas aeruginosa ( P. aeruginosa ), and Staphylococcus aureus ( S. aureus ). The nanoformulations were prepared using spontaneous emulsification and ionic gelation techniques and subsequently characterized for size, zeta potential, and encapsulation efficiency via dynamic light scattering (DLS) and ATR-FTIR spectroscopy. Finally, the antibacterial activity of the nanoformulations was evaluated via the microdilution method. Results revealed that Chi-EO exhibited the smallest hydrodynamic diameter (129 nm) and highest negative zeta potential (− 37 mV), whereas Alg-EO and NE-EO measured 152 nm (− 28 mV) and 144 nm (24 mV), respectively. Notably, Chi-EO demonstrated strongest antimicrobial efficacy, with the lowest IC50 values against S. aureus (321 μg/mL), S. Typhimurium (460 μg/mL), E. coli (367 μg/mL), and P. aeruginosa (504 μg/mL). These findings highlight chitosan nanoparticles serve as an efficient delivery system for Z. multiflora EO, offering a natural and potent approach to improving food safety and extending shelf life.
Mediation of blood lipid levels on the relationship between BMI/WHR and liver function in normal, overweight, and obese individuals
Clarifying the origin of the interpubic cavity using a biomechanical model and the finite element method
Abstract The interpubic cavity is a narrow, slit-like, oval-shaped cavity which has frequently been described within the fibrocartilaginous interpubic disc. The aim of the study was to clarify the origin of the primary interpubic cavity. Knowledge of the physiological load of the pubic symphysis while standing and walking is important when deciding on the load after pelvic fractures and when developing implants to fix injuries in the pubic region, and therefore this knowledge could clarify the origin of the interpubic cavity. It is not possible to measure the load on the pubic symphysis in clinical practice, therefore the authors simulated the load on the pelvis during walking using the finite element analysis. Analyses were performed on a physiological pelvis model loaded with a force corresponding to the reaction force in the hip joint. The pubic symphysis was more heavily loaded with forces from muscle groups, the maximum deformation on the pubic symphysis was localised to two places that are permanently loaded during physiological walking. The area associated with the distribution of reduced stress, the middle and caudal parts of the interpubic disc, correlates very well with the frequency of occurrence of the interpubic cavity. It can therefore be assumed that the cavity helps the joint with load bearing during the transition to bipedal walking, i.e., at the time of high biomechanical load. This study will help us clarify the origin of the interpubic cavity.