Browse Articles

The optimization of vocal music teaching by integrating the STEAM concept with the intelligent recommendation system

Chemical and biological characterization of glycidamide-adducted adenine in DNA

Mapping heartwater risk in Guadeloupe using a combination of spatial modelling approaches

Turning the replisome around

A homology-based 3D model and structure–function studies reveal key elements for divalent metal ion transporter ZIP8 (SLC39A8) function

A generalized heterogeneous federated model for identifying patients with postoperative progression of early-stage non-small cell lung cancer

Abstract In the postoperative management of early-stage non-small cell lung cancer (NSCLC), accurate identification of patients at high risk of progression is essential for developing personalized follow-up schedules and adjuvant treatment strategies. However, in multi-center settings, model and data heterogeneity limit the flexibility and generalizability of traditional federated learning. To address this, we propose a heterogeneous federated learning model (HFLM) that enables centers to adopt different model architectures while using a robust feature transfer strategy to alleviate the impact of heterogeneous data. Using CT images from 892 early-stage NSCLC patients across four medical institutions, HFLM achieved AUCs of 0.863 (95% CI, 0.8072–0.9192), 0.837 (95% CI, 0.7204–0.9530), 0.846 (95% CI, 0.7349–0.9564), and 0.847 (95% CI, 0.6971–0.9963). Cross-validation and stratified analyses further confirm its strong generalization and stability across centers.

MYBPC3 N-terminal missense mutations linked to hypertrophic cardiomyopathy strengthen actin binding and enhance residue mobility

Experimental validation and simulation of a U-Shaped elastic beam robot for stable running locomotion

Abstract This paper presents an innovative terrestrial robot employing a vibration-based locomotion system powered by a single DC motor with an eccentric rotating mass. The robot, composed of a U-shaped aluminum elastic beam and lightweight wooden feet, attains steady mobility by synchronizing torsional vibrations with centrifugal forces. Experimental and simulated analyses were performed at three angular velocities (ω 1  = 125.66 rad/s, ω 2  = 251.33 rad/s, ω 3  = 376.99 rad/s) to assess stability, deviation, velocity, and hopping performance. The results indicated that a rise in angular velocity significantly improved locomotion efficiency. At ω 1 , the robot attained an average body velocity of 85.46 mm/s and a hopping distance of 405.88 mm. At ω 2 , the velocity rose to 221.24 mm/s with a hopping distance of 418.24 mm, but ω 3 achieved optimal performance with a velocity of 265.49 mm/s and a hopping distance of 424.08 mm. Deviation responses settled within ± 2 mm after 2.5 s at ω 3 , in contrast to more pronounced oscillations at ω 1 . Simulation results largely aligned with experimental outcomes in hopping distance (error < 3 mm at ω 3 ) but routinely underestimated body velocity by 50–60%. The findings corroborate the suggested model for predicting vertical displacement, while underscoring the necessity for refinement to accurately capture horizontal velocity dynamics.

Inside Back Cover: Light‐Induced Chemiluminescence Microscopy for Imaging Heterogeneous Photo‐Fenton‐Type Activity on Individual Hematite Photocatalysts (Angew. Chem. Int. Ed. 49/2025)

Modulation of host functions by bacterial serine/threonine protein kinase effector proteins

A longitudinal study on the impact of cadmium exposure on quality of life in esophageal squamous cell carcinoma patients in Southern China

MARCH8-mediated ubiquitination regulates expression of the antiviral protein IFITM3

Knowledge attitude and practice regarding cancer screening among Chinese medical students

Suppressed Concentration Quenching Via Divalent Eu/Sr Alloying in Hybrid Iodides Scintillators Toward Bright Luminescence for X‐ray Imaging

Abstract Overcoming concentration quenching in rare‐earth‐activated luminescent materials always remains a challenge for enhancing photoluminescence quantum yield (PLQY). Herein, we report two divalent Sr‐based hybrid iodides, (Ph 3 MeP)SrI 3 and (Ph 3 EtP)SrI 3 (Ph 3 MeP = methyltriphenylphosphonium, Ph 3 EtP = ethyltriphenylphosphonium), and equivalent Eu/Sr alloying have been identified experimentally in the full range of 0 ≤  x  ≤ 1 for (Ph 3 MeP)Sr (1‐ x ) Eu x I 3 and (Ph 3 EtP)Sr (1‐ x ) Eu x I 3 . These Eu/Sr‐based hybrid iodides exhibit 1D [Sr (1‐ x ) Eu x I 6 ] 4− octahedra chains, suppressing nonradiative energy loss effectively by maintaining optimal spacing and dispersion between adjacent Eu(II) emission centers. Upon even heavily Eu(II) alloying, (Ph 3 MeP)Sr 0.5 Eu 0.5 I 3 exhibits efficient green emission ( λ em = 525 nm) with a high PLQY of ∼92.2%. Accordingly, it achieves a high scintillation light yield of 54 000 ± 300 ph MeV −1 and a low detection limit of 49.9 nGy s −1 . Furthermore, ceramic wafers counterparts of Eu/Sr alloy prepared via cold sintering process demonstrate high‐resolution X‐ray imaging with a spatial resolution up to 15.7 lp mm −1 . These findings not only present a new family of hybrid bimetallic iodides via Eu/Sr alloying, but also provides structurally guided strategy to suppress concentration quenching toward bright luminescence for scintillation applications.

Histone deacetylase HDA-5 regulates lipid metabolism through H4K5 and H4K8 acetylation in Caenorhabditis elegans

Exploring the hub gene CERS6 as a therapeutic target in type 1 diabetes through a bioinformatics and network analyst approach

Transcriptome and chromatin accessibility divergence during differentiation of a bipotential progenitor cell population to erythroblasts and megakaryocytes

Genotype and symbiont composition rather than environment influence susceptibility to stony coral tissue loss disease in coral restoration broodstock

Inside Front Cover: Design of Cryogenic Electrolyte with Organic‐Free Solvation Structure for Wide‐Temperature Zinc Metal Batteries (Angew. Chem. Int. Ed. 49/2025)

A Triple Threat Against Ovarian Cancer: Os(II)‐Pt(IV)‐Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction

Abstract Metal‐based anticancer agents offer unique opportunities to integrate multiple therapeutic modalities within a single molecular framework. Herein, we present the first Osmium(II)‐Platinum(IV)‐Ceritinib conjugate ( Os‐Pt‐Cer ) that synergistically combines photodynamic therapy (PDT), chemotherapy, and immunotherapy via immunogenic cell death (ICD) induction. This heterobimetallic complex features a photoactive osmium(II) polypyridyl core, a platinum(IV) prodrug derived from oxaliplatin, and the kinase inhibitor ceritinib as an axial ligand. Upon deep‐red irradiation ( λ = 740 nm), the conjugate exhibits potent antiproliferative activity in ovarian 2D cancer cells and 3D tumour spheroids, with IC 50 values in the low nanomolar range. In addition, Os‐Pt‐Cer effectively inhibits cancer cell migration. Mechanistic studies reveal that the conjugate induces hallmarks of ICD, including calreticulin exposure, ATP release, HMGB1 secretion and phagocytosis. This multifunctional approach highlights the potential of osmium(II)‐platinum(IV) conjugates as promising candidates for overcoming resistance and immune evasion in high‐grade ovarian carcinoma.