Browse Articles

A General Strategy for Developing Si-Rhodamine-Based Fluorogenic Dyes for Advanced Bioimaging and Biosensing

Constrained model-free adaptive perimeter control and route guidance for large-scale urban networks under aggregate unmeasured disturbance effects

Linker Engineering toward NIR-II Metal–Organic Framework with Maximal Emission beyond 1000 nm for Inflammatory Bowel Disease Imaging

MGMT deficiency augments STING-mediated inflammatory responses accompanied by metabolic alterations in macrophages

Large Thermo- and Mechanosalient Actuation via Cooperative Twist Elasticity-Induced Packing Motif Conversion

Discovery and Biosynthesis of Lanthipeptides Featuring an Azepinoindole Scaffold by Radical <i>S</i> -Adenosylmethionine Enzyme-Catalyzed C–C Bond Formation

Size-Selective CO ₂ Activation at Rhodium Cluster Anions

Higher Excited-State Reactivity of a Charge-Neutral Organic Radical

Enantiopurity-Controlled Magnetism in a Two-Dimensional Organic–Inorganic Material

Probing Stage Transition Kinetics in Li-Graphite Intercalation Compounds by Time-Resolved In Situ Solid-State NMR via ¹³ C Labeling

GraPhAI: Neural Networks for Solving Centrosymmetric Crystal Structures

Photoelectrocatalysis-Enabled C(sp ³ )–C(sp ³ ) Cross-Coupling of Carboxylic Acids with Alkyl Halides

Utilizing Light to Control Glycopolymer–DC-SIGN Interactions via Molecular Motors

Reprogramming Aromatic Camptothecins into TOP1 Degraders via Synergistic Hydrophobic Tagging and Supramolecular Assembly

Time-resolved morphological and transcriptomic characterization of early enteric neuron subtype emergence in chick

The genetic programs directing nascent enteric nervous circuits and their unique architecture remain poorly characterized. To gain insight, we combined manipulations in the chick embryo model, whole gut three-dimensional (3D) imaging, and single-nucleus transcriptomics at very short intervals for time-resolved analyses of neuronal subtype trajectories. In imaging, we found highly dynamic axon network growth, with rapid increase in axon density and spatial orientation diversification. At transcriptomic levels, we correlated these changes to cell-state transitions with specific axon guidance gene sets. Cross-analyses with human and mouse embryo scRNAseq and expression profiles revealed globally conserved enteric lineage trajectories and subtypes specific axon guidance programs in all species. Finally, manipulation of DSCAM and ISLR2 evolutionary conserved networks in chick whole gut cultures altered enteric axon patterns, validating our paradigm and its applicability to advance current knowledge on human enteric circuit wiring.

Prevalence and patterns of use of dietary supplements and OTC medications for mood improvement and stress relief among adults in Poland

Turning policy implications into policy impact: Lessons from behavioral science in financial markets

We describe how research can inform policymaking. We begin by summarizing the policy formation process, offering a framework illustrating how interactions between scientists and policymakers can provide mutual benefits. We then describe four research initiatives from the Securities and Exchange Commission’s Office of Investor Research (OIR) as examples of how behavioral sciences can help inform policymakers. The first initiative established a probability-based nationally representative survey panel focused on US investor behavior. The remaining three examined investor communications for mutual fund benchmarks, emerging annuities (known as registered index-linked annuities), and mutual fund fee visuals. We conclude by synthesizing our work and describing practices that can help scientists have policy impact, not just policy implications.

Research on γ-photon scattering correction method based on R-SSS algorithm

Bumblebees’ orofacial reactions to tastes provide evidence for affective evaluation

Facial expressions provide a critical window into the internal states of animals, allowing the identification of affective processes and their underlying neural mechanisms. In mammals, postconsumption orofacial reactions—such as tongue protrusions to sweet tastes—are among the most robust and widely accepted behavioral markers of positive hedonic impact (liking), distinct from motivation (wanting). However, no equivalent markers have been established in insects, leaving their capacity for affective evaluation unresolved. Here, we show that bumblebees exhibit discrete orofacial reactions that are functionally analogous to those described in mammals. Bees displayed postconsumption glossa protrusions to rewarding solutions and head-shaking and mouth-wiping to aversive tastes. These reactions were not tied to any specific taste identity. Behavioral and pharmacological experiments demonstrated that glossa protrusions did not automatically occur due to consumption, were independent of ongoing feeding mechanisms and dopamine-mediated motivation, and were enhanced by the endocannabinoid anandamide. Our findings support postconsumption glossa protrusions as a fast, reliable, and evolutionarily comparable candidate behavioral marker of affective evaluation in an invertebrate. By providing evidence that a behavior which tracks liking can be dissociated from motivational (wanting) responsiveness in bumblebees, this work establishes an experimental framework for investigating the neural basis and evolutionary origins of affective processing. More broadly, these results open the door to rigorous cross-phyletic approaches to emotion.

The resuscitation team members’ lived experiences regarding futile cardiopulmonary resuscitation in children and newborn infants: A phenomenological study