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Horizontally arranged covalent organic framework nanowires on poly(amidoxime) fibers for high-efficiency uranium capture
Development of a hybrid Pumped-storage Hydropower–photovoltaic complementary system and analysis of its complementarity characteristics
Soliton-assisted massive signal broadcasting via exceptional points
Enhanced dielectric response and thermally activated charge transport in co-precipitated nanostructured chromium oxide systems
Plasma wave observations from Juno spacecraft at the Jovian bow shock
Machine learning assisted surrogate modeling with multi objective optimization and decision making of a steam methane reforming reactor
Curving transparent ceramics via force-driven sintering
Digital twin state-realignment-based cloud infrastructure for resource allocation and fault prediction using HCPF and LST-TICaLUM
Perioperative myeloid cell remodeling shapes CAR-T cell efficacy in glioblastoma
Abstract Glioblastoma (GBM) is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that constrains the efficacy of chimeric antigen receptor (CAR)-T cell therapy. Here, we show that surgical resection in both male mice and human GBM ex vivo induces a rapid and sustained remodeling of the TME, marked by upregulation of TREM2 in myeloid cells followed by emergence of T cell exhaustion-like phenotypes. In male mice, targeting TREM2 reshapes the perioperative TME and potentiates tumor antigen-specific CAR-T cell responses, improving intratumoral persistence, proliferation, and effector differentiation, and resulting in enhanced survival. In parallel, we identify the timing of CAR-T cell administration as a critical determinant of therapeutic outcome, with neoadjuvant outperforming adjuvant treatment by preserving CAR-T cell effector function in mice. These findings establish perioperative myeloid cell remodeling and treatment timing as key determinants of CAR-T cell efficacy in GBM.
Favorable outcome of engraftment of custom designed RADA16-I based hydrogels functionalized with SDF1 or IL4 mimicking peptides to injured or dystrophic muscles
All-Optically Controlled Memristive Reservoir Computing Capable of Bipolar and Parallel Coding
Dynamic thermography used to support the diagnosis of diabetic foot with the assessment of balance and foot positioning
Abstract The aim of this study was to evaluate the usefulness of dynamic thermography combined with controlled foot cooling in detecting changes associated with diabetic foot abnormalities and to investigate the relationship between plantar thermal asymmetry, subjective pain, and body-load distribution. The study included 45 participants: 36 patients with diabetes and 9 healthy controls. Participants were divided into four groups: controls ( n = 9), diabetic patients with foot pain (D-pain, n = 8), diabetic patients with neuro-metabolic disorders/neuropathy (D-neuropathy, n = 9), and diabetic patients with other minor comorbidities (D-other, n = 19). Thermograms were acquired before and after controlled cooling of the feet to 17 °C using a custom-designed heat pump-based cooling platform. Temperature differences (ΔT) between ten corresponding anatomical points of the left and right foot were analysed. Anatomical point significantly affected ΔT ( P < 0.001), and a significant Group × Point interaction was observed ( P < 0.001), indicating that the distribution of thermal asymmetry depended on the foot region and clinical group. The D-pain group showed the most pronounced local asymmetry at L9_R9. Pain intensity differed significantly between groups ( P = 0.002), whereas body-load asymmetry (ΔL) did not ( P = 0.951). The method appears promising as an adjunctive, non-invasive screening approach, but further validation in larger and clinically more homogeneous cohorts is required.
Radiographic Progression With and Without Prostate-Specific Antigen Rise in Patients With Advanced Prostate Cancer Treated With Enzalutamide
A machine learning framework for predicting and modulating condition-dependent protein phase separation
Discovery of basaltic and magnesian andesite magmas within the Hunga volcanic system, Tonga arc
Reply to: Statistical and Methodological Considerations in the Evaluation of Ultra-Low-Dose Nivolumab
Direct observation of braiding of Majorana-like zero modes in real space
Abstract Majorana zero modes (MZMs) lie at the heart of fault-tolerant topological quantum computation, where their non-Abelian braiding statistics enable logical operations intrinsically immune to local perturbations and decoherence. Analogs of MZMs, known as Majorana-like zero modes (MLZMs), have recently been proposed in artificial lattices. Despite this progress, a direct real-space observation of the braiding process has remained elusive, representing a fundamental gap between theoretical prediction and experimental realization. Here, we demonstrate the direct observation of the braiding of MLZMs. We identify boundary-bound MLZMs (BMLZMs) that are spatially well separated and can be adiabatically transported along the sample boundary through controlled modulation of the Kekulé phase. By mapping the acoustic-field evolution, we construct the complete real-space trajectory and observe the phase accumulation characteristic of the braiding process. These results establish BMLZMs as a new class of topological excitations and provide a directly observable analog of Majorana braiding dynamics.