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Symmetry-driven gating of TRPM8 by PIP2 and menthol
Design of a 140 GHz TE28,8 gyrotron quasi-optical mode converter
Mitochondrial translation termination, recycling, reinitiation, and rescue for in-frame and out-of-frame contexts
Immobilization of nanostructured NiFe2O4 on mesoporous TiO2 as an efficient Z-scheme photocatalyst for high-performance photocatalytic degradation
Abstract In the present study, the synthesis of nickel ferrite nanoparticles immobilized on mesoporous TiO 2 was investigated to produce an efficient photocatalyst. For this aim, nickel ferrite nanoparticles were synthesized via a citrate-nitrate method, and then a modified surfactant-assisted procedure was employed to immobilize nanostructured NiFe 2 O 4 on mesoporous TiO 2 . In order to study the photocatalytic properties of the samples, the photodegradation of methyl orange under solar simulated irradiation was examined. The fabricated samples were assessed using SEM, TEM, XRD, BET, and UV-DRS. For indirect transitions, the energy band gap values were determined to be 3.22 eV for mesoporous TiO 2 and 3.15 eV for the NiFe 2 O 4 /TiO 2 sample. Immobilization of nanostructured NiFe 2 O 4 on mesoporous TiO 2 caused an anisotropic lattice distortion in the titania structure. The kinetic constant for methyl orange photodegradation by TiO 2 /30wt.%NiFe 2 O 4 reached 0.0153 min − 1 under solar simulated irradiation, which was 4.6 times greater than that of pure NiFe 2 O 4 , 3.1 times that of mesoporous TiO 2 , and 2.5 times that of TiO 2 /20wt.%NiFe 2 O 4 . The possible photodegradation mechanism of the synthesized nanocomposite was proposed. The demonstrated recyclability of these composites highlights their potential as sustainable materials for high-efficiency wastewater treatment.
Domvanalimab plus zimberelimab in unresectable and immunotherapy refractory biliary tract cancers: a phase 2 trial
Comparison of 2D and 3D fast non-local means in pediatric abdominal low-dose computed tomographic image
Dual compartment lipid carriers hijack exocytosis to empower natural killer cells against solid tumours
Abstract Solid tumours resist adoptive cell therapies through lactate driven immunosuppression, which depletes intracellular nicotinamide adenine dinucleotide, suppresses interferon gamma production in T cells, and reprogrammes macrophages. Here we show that a dual compartment lipid carrier system hijacks exocytosis for spatiotemporal metabolic reprogramming. Lipid nanoparticles deliver nicotinamide mononucleotide to restore intracellular nicotinamide adenine dinucleotide, while endoplasmic reticulum targeted carriers exploit the endoplasmic reticulum to Golgi pathway to achieve trafficking directed exocytic dichloroacetate export, enabling precise lactate depletion without systemic toxicity. This integrated approach rewires the metabolic landscape, extends natural killer cell persistence and reactivates cytolytic function. Endoplasmic reticulum engineered natural killer cells achieve potent tumour suppression through spatiotemporal metabolic reprogramming, a platform strategy that also extends to conventional T cell and macrophage therapies for enhanced therapeutic efficacy across adoptive cell systems. Our work establishes exocytosis co option as a strategy to empower cellular therapies and improve antitumour efficacy against lactate rich solid cancers.
Diversity of insecticidal A1b homologs among legume seeds from Middle Eastern region
Behaviourally driven closed-loop beta-tACS enhances beta activity and motor behaviour
Abstract Movement-related beta event-related synchronization (ERS) has been linked to motor control and learning, showing potential as a therapeutic target for those with movement deficits, such as stroke survivors. However, whether directly modulating beta ERS can causally influence motor performance remains unclear, largely due to the lack of methods designed to specifically target this neural activity. To address this gap, we developed a behaviourally-driven, closed-loop transcranial alternating current stimulation (tACS) approach to target movement-related beta ERS during a visuomotor adaptation task. We found that the behaviourally-driven, closed-loop beta-tACS specifically enhances beta ERS without affecting beta event-related desynchronization (ERD). Critically, this targeted enhancement significantly improves retention of motor adaptation. These findings support a functional role of beta ERS in motor behaviour and suggest that behaviourally-driven beta-tACS may provide a promising approach to further test the mechanistic links between beta ERS and behavioural outcomes in clinical populations.
Group dynamics as moderators of deep interaction in blended learning: an empirical investigation
Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease
First report on the chemical profile and antioxidant activity of Moroccan Crithmum maritimum essential oils
Abstract Sea fennel ( Crithmum maritimum L.) is a wild halophyte valued for its culinary, medicinal, and cosmetic applications owing to its rich nutritional profile and distinctive sensory properties. This study provides the first investigation of essential oils (EOs) extracted from different parts of Moroccan C. maritimum (leaves, inflorescences, and stems) using hydrodistillation, with the aim of evaluating their phytochemical composition and bioactive potential. The oils were characterized by gas chromatography–mass spectrometry (GC–MS), while total phenolic content (TPC) and antioxidant activity (DPPH and FRAP assays) were assessed spectrophotometrically. The highest EO yield was obtained from inflorescences (0.59%), followed by leaves (0.44%) and stems (0.28%). GC–MS analysis identified more than 30 compounds, with dillapiole (16.41–32.47%), γ -terpinene (18.31–32.34%), and thymol methyl ether (19.76–22.33%) as the major constituents. Stems and leaves exhibited the highest phenolic contents (17.97 ± 1.07 and 17.64 ± 0.75 mg GAE/g EO, respectively), while inflorescences contained significantly lower amounts (15.17 ± 0.09 mg GAE/g EO). Antioxidant evaluation showed that leaf oil possessed the highest radical-scavenging capacity (DPPH), whereas stem oil demonstrated the greatest reducing power (FRAP). Molecular docking calculations were conducted to model the interaction between the six major constituents of C. maritimum EOs (dillapiole, γ -terpinene, thymol methyl ether, p -cymene, β -terpinene, and terpinen-4-ol), to evaluate their potential antioxidant activity. Among the identified C. maritimum EOs compounds, thymol methyl ether exhibited the most favorable binding profile with both target proteins NAD(P)H oxidase (PDB ID: 2CDU) and nitric oxide synthase (PDB ID: 6NGI), highlighting its potential as a broad-spectrum antioxidant. Overall, despite organ-dependent variations in yield and composition, all Moroccan C. maritimum EOs were rich in bioactive compounds with recognized biological properties. These findings highlight their potential for sustainable applications in nutraceutical, cosmetic, and food industries, supporting future valorisation of this halophyte through eco-friendly processing technologies.
Daily briefing: Baby T. rex were tiny but deadly
Coverage engineering by shell-number-controlled nanoconfinement enables nitric oxide electroreduction in the ppm regime
Synthetic MRI pretraining for medical imaging classification
Monolithic 6-Axis Force/Torque Sensing by a Single Ultrathin Piezoceramic Shell
Development, characterization, and optimization of biodegradable composite films from waste potato peel starch reinforced with avocado peel pectin and sisal fiber for packaging applications
Does China’s latest AI model finally equal US rivals? What scientists think
Trans-scale spin Seebeck effect in nanostructured bulk composites based on magnetic insulator
Abstract The spin Seebeck effect enables thermoelectric conversion through thermally generated spin currents in magnetic materials, offering a promising transverse geometry for scalable devices. However, conventional spin Seebeck devices are confined to nanoscale thin-film architectures, with significantly restricted output power due to the intrinsic constraints of spin and magnon diffusion lengths. Here, we demonstrate a trans-scale spin Seebeck effect using nanostructured bulk composites composed of Pt-coated yttrium iron garnet powders fabricated via dynamic powder sputtering and low-temperature sintering. The resulting three-dimensional composites exhibit continuous Pt channels and robust mechanical integrity. Transverse thermoelectric measurements reveal isotropic spin Seebeck signals at the bulk scale. Power analysis indicates that the three-dimensional architecture enables scalable volumetric thermoelectric power generation beyond diffusion-limited thin-film spin Seebeck geometries. This work establishes a scalable platform for spin Seebeck thermoelectric conversion, bridging nanoscale spin caloritronics with macroscopic device integration.