Browse Articles
Discover research articles across all indexed journals
Proton Location in a Hybrid Molybdenum Bronze
Preparation and response study of microcrystalline cellulose/fish bladder gelatin actuator
A redox flow battery coupling energy storage and chemical manufacturing in a single device
A Light-Driven Constitutional Pump
Expectation management in humans and LLMs
The deubiquitinase USP4 stabilizes the SCFFBXO24 ubiquitin E3 ligase to regulate immunity in experimental pneumonia
Dynamics of (Hetero)aryl Motifs: An Integrative Approach To Study the Conformational Landscape in Macrocycles
Alternating Current-Driven Hydrogen Isotope Labeling of Aliphatic Amines Using 1,3-Propanedithiol as an Efficient Hydrogen Atom Transfer Reagent
Pilot study on microwave preclinical system for targeted delivery of fractionated hyperthermia in murine solid tumors
Iterating the transient light transport matrix for non-line-of-sight imaging
Enhancing CO Oxidation Rate via Electronic Tuning of CO Binding on Bimetallic Nanoparticle Catalysts
Solid-Phase Glycolipid Synthesis Expedites Liposome Functionalization
A rationalized molecular and genomic coupled strategy to get a snapshot of the tuberculosis transmission in Madrid
Comparative regulomics of wood formation across dicot and conifer trees
Abstract Understanding the regulatory program underlying wood formation is key to improving biomass production and carbon sequestration in trees. However, how wood formation evolved and how these programs have been rewired across lineages remains unclear. Here, we present the first high-spatial-resolution evo-devo resource for wood transcriptomes spanning multiple dicots and conifers, representing the two major tree-containing lineages separated by more than 300 million years of evolution. Using orthology-aware co-expression network analysis, we identified genes with conserved and lineage-specific expression patterns. By integrating chromatin accessibility data and transcription factor motif analysis, we further inferred candidate regulatory networks for xylem differentiation and secondary cell wall formation. We demonstrate how this dataset can be used to answer long standing questions in wood biology related to differences in acetylation of cell wall polymers and master regulators of xylem specification across dicot and conifer tree species. The data offer a resource for the tree biology and evo-devo communities, and are publicly available at PlantGenIE.org.
Lipoprotein and inflammatory glycoprotein profiles in women with polycystic ovary syndrome alone or in association with type 1 diabetes
Zinc-phosphorus nanodomains with dynamic coordination for electrochemical CO2 reduction
Thermal behavior of single energy pile in saline soil environments
Structural insights enable drug discovery for the neuronal NBCn2 carbonate transporter
Abstract NBCn2 (SLC4A10), a member of the SLC4 solute carrier (SLC) family, is a sodium-dependent (bi)carbonate transporter that regulates acid extrusion in various brain regions. Mutations in NBCn2 cause severe neurodevelopmental disorders in humans, and knock out studies suggest that its role in regulating neuronal excitability could hold therapeutic potential for seizure disorders such as epilepsy. Despite its physiological importance, NBCn2’s molecular mechanisms remain largely unknown, and there is limited availability of tool compounds to further probe its role in health and disease. Combining cryoEM with computational docking and simulation studies, we herein elucidate NBCn2’s molecular architecture and substrate binding mechanisms on the atomic scale. Via structure-based drug discovery we further identify a compound series that inhibits NBCn2-mediated transport, and characterize its inhibitory mechanisms via cryoEM. Lastly, we showcase the potential of this compound series to template useful probes by demonstrating pharmacological activity both in primary culture as well as brain slices.