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Electronic health record dynamic features for in-hospital death among chronic kidney disease patients
Synthesis and evaluating gamma shielding features of YBa2Cu3O7(Bi2O3) ceramic composite using Monte Carlo method via GEANT4 and MCNP codes
A bioeconomic performance index for comparison of an experimental intensive aquaponic system with tilapia and tomato versus aquaculture and hydroponics
Hybrid diagnostic framework for bone cancer detection using deep learning and radiomics analysis
Facile synthesis and synergistic cytotoxic effect of Ag/Co-ZnO nanoparticles in epithelial breast cancer cells
Optimizing solid waste, effluents and blockchain technology efforts towards a sustainable palm oil stochastic supply chain model
A lightweight causal Mamba network for blurred QR code image restoration
Research on ChatGPT generated text detection model based on phonetic feature extraction and semantic features
Application management and effectiveness analysis of intelligent logistics robots in hospital drug and specimen delivery scenarios
Improving the bearing capacity of helical tapered piles using gum injection in FCV
Structural, electronic, mechanical, optical, and thermodynamic properties of novel quaternary oxychalcogenide LaCuTeO for optoelectronic applications
Detection of New Delhi metallo-β-lactamase (blaNDM) and oxacillinase (blaOXA-48) genes among carbapenem-resistant Enterobacteriaceae (CRE) in Jazan Region, Saudi Arabia
Abstract Carbapenem-resistant Enterobacteriaceae (CRE) are critical priority pathogens due to their resistance to carbapenems, the last-resort antibiotics, and their rapid spread in healthcare facilities. The study investigates the epidemiological and molecular characteristics of CRE isolates in the Jazan region, Saudi Arabia. Clinical specimens were collected from patients admitted to Jazan General Hospital between December 2023 and May 2024. Identification of the isolates was done by the VITEK 2 system, and their susceptibility to antibiotics was determined on the MicroScan WalkAway platform according to the EUCAST guidelines. The E-test was used to confirm the CRE isolates. Molecular detection of carbapenemase genes ( bla IMP , bla VIM , bla NDM , bla KPC and bla OXA-48 ) was conducted using the GeneXpert Carba-R assay using the GeneXpert®. A total of 426 Enterobacterial clinical isolates were collected from patients; among them, 53 (12.4%) were phenotypically found to be CRE; among such isolates, 14 (26.4%) were found to be carbapenemase-positive Enterobacteriaceae (CPE), and 39 (73.6%) were carbapenemase-negative Enterobacteriaceae (CNE). Among the CPE strains, Klebsiella pneumoniae was the predominant organism (42.9%), followed by Escherichia coli (28.6%), Enterobacter cloacae (21.4%), and Serratia marcescens (7.1%). Molecular analysis revealed a high prevalence of the bla NDM gene (71.4%), with bla OXA-48 detected in 42.9% of isolates. The bla VIM was identified in only 7.1%, while neither the bla KPC nor bla IMP is detected. For the CNE strains, K. pneumoniae was most common (62%), of which 15% produced extended-spectrum β-lactamase (ESBL). The isolates were all highly resistant to penicillin and β-lactam/β-lactamase inhibitors, moderately susceptible to fluoroquinolone (33%) and aminoglycosides (49%), and most susceptible to tigecycline (79%). The bla NDM was mainly found among ICU patients, while bla OXA-48 was most frequently identified among pediatric patients. The ICU admission with invasive devices, and prior broad-spectrum antibiotic exposure emerged as the main risk factors for the evolution of CPE. Multiple comorbidities; particularly malignancy, diabetes, and surgery; further increased vulnerability to CPE infections. Jazan city has a lower prevalence of CPE, while non-carbapenemase resistance is most predominant, reflecting regional epidemiological heterogeneity, which is important for regional stewardship and control.
USP7-dependent stabilization of FKBP4 contributes to acquired osimertinib resistance through glycolytic remodeling in NSCLC
Carbonate framework and sediment production across island-fringing coral reef habitats and a natural nutrient gradient
Abstract Coral reef framework production and sediment generation are key controls on vertical reef accretion and reef island maintenance. However, quantitative data on these geo-ecological functions remain scarce, particularly within shallow habitats that mediate incoming wave energy and sediment supply to shorelines. This study quantified carbonate framework and sediment budgets across shallow lagoon reef (1–2 m), shallow forereef (2–3 m) and deep forereef habitats (8–9 m) surrounding six islands within three atolls (2 islands/atoll) in the remote Chagos Archipelago, Central Indian Ocean. One of the islands in each atoll supports dense seabird colonies that deliver natural nutrient subsidies to nearshore habitats via guano run-off, enabling assessment of nutrient impacts on reef carbonate dynamics. Benthic surveys ( ReefBudget and SedBudget ) were combined with sediment composition analyses from shallow reefs and adjacent beaches. Variation in coral cover and composition among atolls, linked to differences in atoll size and post-2016 bleaching recovery, resulted in higher framework production at Salomon Atoll. After accounting for atoll-level variability, framework production exhibited habitat-specific patterns, with highest mean rates at lagoon reefs (5.5 kg m ⁻2 yr ⁻1 ), followed by deep and shallow forereefs (3.5 and 3.1 kg m ⁻2 yr ⁻1 , respectively). Reefs adjacent to seabird islands showed enhanced framework production at lagoon and shallow forereef sites (by + 3.7 and + 3.1 kg m ⁻2 yr ⁻1 , respectively), driven by increased coral calcification and reduced parrotfish grazing. Sediment production was dominated by parrotfish erosion, with highest rates at deep forereefs (3.0 compared to 1.3 kg m ⁻2 yr ⁻1 at shallow reefs), little variation among atolls, and a limited response to nutrients. Sediment composition was dominated by reef framework constituents (coral and crustose coralline algae), with secondary contributions from Halimeda , molluscs and benthic foraminifera. Beach sediments resembled shallow reef sediments, both showing increased Halimeda near nutrient-enriched reefs due to past calcareous algal blooms. Our findings demonstrate how different spatial scales and seabird-derived nutrients modulate carbonate production in remote reef island systems.