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Urolithin A improves motility, antioxidant defense, and mitochondrial function of chilled canine spermatozoa during 72-h liquid storage
Design and optimization of double semi-cylindrical plasmonic nanostructures for enhanced light harvesting in ultrathin CIGS solar cells
Advanced detection of coronary artery disease using a GAN-transformer model on plasma cytokine profiles
Effects of cellular receptors on the vaccine efficacies of adenovirus vector-based vaccines following intramuscular and intranasal administration
Data-driven climatic zoning and future trend forecasting in Chad using artificial neural networks
Effects of planting patterns of shuikou Woodland on outdoor wind environment in traditional villages
Multi-stimuli and AI-guided electrically-responsive self-healing nanocomposites for low-temperature structural applications
Emergence and predominance of GII.17[P17] noroviruses in Brazil, 2023–2024
Abstract Norovirus is a leading cause of acute gastroenteritis (AGE) worldwide, affecting all age groups. In the present study, we investigated fecal samples from medically attended AGE patients received from ten Brazilian states collected during 2023 and 2024. Norovirus GI and GII were detected and quantified using RT-qPCR, and norovirus-positive samples underwent genotyping through sequencing the ORF1/2 junction region. During the two-year period, norovirus prevalence was 22.5%. GII genotypes were predominant, accounting for 85.6% of the genotyped samples. By genotyping, we detected the circulation of 19 norovirus genotypes, of which the emergence of GII.17[P17] in 2023 and its predominance in 2024. Comparison of cycle threshold (Ct) values indicated that the median viral load was significantly higher for norovirus GII.17 compared to GII.4 (20.9 and 22.3, respectively ( p = 0.0493). Additionally, we showed that GII.17 patients were older compared to GII.4 patients. Our study is the first in South America to demonstrate replacement of the previous dominant genotype (GII.4 Sydney[P16]) to GII.17[P17] in 2024, currently disseminated worldwide.
Associations between women’s childhood maltreatment and thyroid function before and during pregnancy
Abstract Maternal childhood maltreatment has been associated with complications during pregnancy and neurodevelopmental disorders in offspring. Thyroid dysfunction could be a mechanistic pathway underlying this relationship. The thyroid is vital for reproductive health in women, maintaining menstrual cycles, fertility, and pregnancy. However, little is known how childhood maltreatment affects thyroid function in women contemplating pregnancy and those who are pregnant. Participants were from the Nurses’ Health Study 3, including 217 women contemplating pregnancy and 156 pregnant women, all reporting childhood maltreatment using a validated 28-item Childhood Trauma Questionnaire. Thyroid function tests were plasma thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroperoxidase antibody (TPOAb). Regression analyses were conducted. Among women contemplating pregnancy (n = 217), childhood maltreatment was consistently associated with lower FT3 levels, but not with FT4, TSH, or TPOAb levels. FT3 levels were 5% to 7% lower in those with mild to severe childhood maltreatment compared to those without. Among pregnant women (n = 156), no significant associations were observed between childhood maltreatment and thyroid function. In conclusion, childhood maltreatment was associated with low thyroid function (e.g., FT3) among women contemplating pregnancy, but not among pregnant women. Future large, prospective, racially and ethnically diverse studies are needed to confirm our findings.
Estimation of spatiotemporal poisson processes with missing data
Increased remodeling of type XXII collagen is associated with an inflammatory phenotype in Crohn’s disease
Subclinical overhydration predicts lower time in range and greater glycemic variability in type 2 diabetes on hemodialysis
Differential associations between subjective and objective physical activity and memory across adulthood: a specification curve analysis
Establishment of a prognostic model for hepatocellular carcinoma patients based on bioinformatics analysis and exploration of prognostic biomarker EPPK1
Molecular dynamics investigation of temozolomide encapsulation and controlled release from PLGA carriers
Contemporary management and outcomes of penetrating traumatic AAST–OIS grade III and IV kidney injuries undergoing laparotomy: a Trauma Quality Improvement Program analysis
Abstract This study aimed to compare the outcomes of renal salvage (no nephrectomy) to nephrectomy patients with a penetrating American Association for the Surgery of Trauma–Organ Injury Scale grade III or IV kidney injury. The 2013–2021 Trauma Quality Improvement Program dataset was queried for patients with a penetrating grade III or IV kidney injury who underwent laparotomy within 24 h of admission. The association between nephrectomy and binary outcomes was investigated using Poisson regression models, with results presented as a prevalence ratio (PR) and corresponding 95% confidence interval (CI). A total of 2,214 grade III and 2,669 grade IV kidney injuries were identified. 89% of grade III injuries and 54% of grade IV injuries were managed without nephrectomy. After adjustment for confounding, nephrectomy in patients with a grade III penetrating kidney injury was associated with an increased risk of mortality [adjusted PR (95% CI): 1.53 (1.06–2.20), p = 0.023], complications [adjusted PR (95% CI): 1.25 (1.05–1.48), p = 0.010], post-complication mortality [adjusted PR (95% CI): 1.80 (1.09–2.96), p = 0.022], and ICU admission [adjusted PR (95% CI): 1.05 (1.00-1.11), p = 0.046], compared to renal salvage. In patients with a grade IV penetrating kidney injury, nephrectomy was only associated with an increased risk of ICU admission [adjusted PR (95% CI): 1.06 (1.02–1.09), p = 0.001], compared to renal salvage. Consequently, in patients with a grade III penetrating kidney injury, nephrectomy was associated with an increased risk of adverse outcomes. Among patients with a grade IV injury, nephrectomy was associated only with an increased risk of ICU admission. However, given the potential for residual confounding, these findings should be interpreted with caution.