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Merging photocatalysis with C-H insertions enabled switchable synthesis of indoles and indolines
App-based epidemic game in a university campus reveals how risk perception and behavioral interventions shape disease transmission dynamics
Artificial chemotaxis in micro/nanomotors
Abstract Chemotaxis is the directional motion of objects in response to chemical gradients, a process that drives navigation in micro/nanomotors, enabling a bio-inspired transition toward autonomous direction control. However, current studies lack consistent mechanistic justification, definition, and standardized experimental validation. This review summarizes key physical principles governing active chemotaxis, surveys experimental strategies for generating chemical gradients and quantifying responses, and examines how individual chemotactic mechanisms and long-range, anisotropic chemical interactions give rise to emergent collective behaviors, while outlining prospective applications. Together, these efforts establish a principled engineering framework for advancing chemotaxis as a robust functional navigation modality in synthetic micro/nanomotors.
Opposing end-node and junction-node remodeling patterns in diabetic patients on optical coherence tomography angiography
Trap-assisted circularly polarized organic photodetector
Abstract The innovative design of π-conjugated molecules enables the creation of chiral π-systems that selectively interact with circularly polarized light. In circularly polarized organic photodetectors, the use of π-conjugated molecules with highly dissymmetric circularly polarized absorption has been a key strategy for achieving strong differential electrical signals with circularly polarized light. However, factors beyond absorption that influence asymmetric device behavior remain insufficiently explored. In this work, we demonstrate trap-assisted circularly polarized organic photodetectors based on blend systems containing small amounts of achiral acceptors, enabling asymmetric trap filling depending on the handedness of circularly polarized light. Modulated trap dynamics play a crucial role in asymmetric charge extraction, significantly enhancing circularly polarized selectivity. We realize a large-area organic circularly polarized imaging system (4096 pixels) and showcase its potential for real-time visual encryption. This study presents a design strategy for efficient circularly polarized photodetectors with tailored carrier dynamics.
Cancer incidence in the Pijao indigenous population of colombia using administrative health records, 1996–2022
Click/release reaction and SO2 recycling for multichannel dynamic chiroptical materials
Aligned electrospun porous P34HB/lecithin scaffold for bone tissue regeneration
Action potential propagation in the rodent myelinated optic nerve does not trigger neurovascular coupling
The use of leaded paints in an urban neighborhood in Quito, Ecuador: A case study
Early and late RNA eQTL are driven by different genetic mechanisms
A vessel trajectory similarity measurement and clustering method based on multi-modal convolutional auto-encoder algorithm
Non-destructive transcriptomics via vesicular export
Abstract Transcriptomics enables comprehensive, multiplexed characterization of cellular states, yet prevailing methods typically require cell fixation or lysis, precluding longitudinal analysis of RNA expression in living cells. Here, we present non-destructive transcriptomics by vesicular export (NTVE), a platform for multi-time-point monitoring of RNA expression dynamics in living cells. Stabilized RNA reporter barcodes can be selectively packaged and exported from cells via virus-like particles (VLPs) bearing bioorthogonal affinity handles for convenient multichannel tracking of co-cultured cells. Using an engineered poly(A)-binding protein adapter, NTVE exports endogenous transcripts from inducible human and murine cell lines with high concordance to conventional lysate-derived RNA-seq. NTVE captures transcriptome changes in response to genetic and chemical perturbations within the same cells over time using standard sequencing workflows. NTVE can further be equipped with fusogens to deliver mRNA-encoded effectors or ribonucleoprotein gene editors from sender cells, activating gene reporters in co-cultured recipient cells. We demonstrate the utility of NTVE for monitoring hiPSC differentiation through daily non-destructive transcriptomic profiling of lineage-specific marker dynamics.
USP10 inhibits the apoptosis of lens epithelial cells and delays the progression of diabetic cataract via the deubiquitination and stabilization of MCL1
Lightweight vision architecture deployed in the terminal for safety monitoring and early warning of transmission lines
Dissecting temporal regulation of the TLR4–IL-6 axis using systematic targeted inhibition
Identification of synovial lymphatic system in the temporomandibular joint and their roles in arthritis and pain
Solvatochromic, spectroscopic, DFT calculations, antimicrobial and docking studies of new Fe(III), Co(II), and Ni(II) chelates containing 1,2,4-triazine
Abstract This study presents the synthesis and characterization of three novel metal chelates: Ni(DTHMN) ( 1 ), Co(DTHMN) ( 2 ), and Fe(DTHMN) ( 3 ). Comprehensive analytical techniques, including elemental analysis, infrared (IR) and electronic (UV-Vis) spectroscopy, thermal analysis, molar conductivity, and magnetic susceptibility measurements, were employed to investigate their structural and electronic properties. The findings indicate that the ligand DTHMN acts as a tridentate donor, coordinating through the hydroxyl group (O–H), azomethine nitrogen (C = N), and triazine nitrogen atoms, forming mononuclear chelates with tetrahedral or octahedral geometries. X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses confirmed that the Ni(DTHMN) chelate adopts a nano-spherical to cubic morphology. All synthesized chelates exhibit luminescence behavior, suggesting potential utility in photoactive materials. Solvatochromic shifts in absorption and fluorescence spectra were analyzed to estimate ground-state (µ g ) and excited-state (µ e ) dipole moments. These were determined using Reichardt’s solvent polarity parameter (E T N ) and multiple empirical functions, including the Bilot–Kawski, Lippert–Mataga, Bakhshiev, and Kawski–Chamma–Viallet models. A notable increase in dipole moment upon excitation suggests enhanced stabilization of the excited state in polar solvents, particularly involving n–π* transitions. Density Functional Theory (DFT) calculations, performed using the B3LYP/GENECP method with a 6-311G(d, p) basis set for non-metal atoms and SDD for metal atoms, supported experimental data and provided insights into optimized structural parameters. Further computational analyses included molecular electrostatic potential (MEP) mapping and nonlinear optical (NLO) property evaluation, revealing charge distribution and optical characteristics. The antimicrobial activity of the complexes was tested against a panel of Gram-positive, Gram-negative bacteria, and fungi, showing promising efficacy. Finally, molecular docking studies were conducted to investigate the binding interactions of the chelates with the FabH–CoA enzyme complex (PDB ID: 1HNJ), providing insight into their potential as bioactive agents.