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The Somatic Rubber Hand Illusion does not modulate perceived hand position in children with severe visual impairments
Predicting immunohistochemical expression status and molecular subtypes using synthetic magnetic resonance imaging and multiple multiplexed sensitivity encoding diffusion weighted imaging in breast cancer: a prospective study
The influence of different regulatory patterns of miRNA-target genes on the pigmentation of the Chinese soft-shelled turtle (Pelodiscus sinensis)
CT radiomics approach to predict response to bronchial arterial chemoembolization in advanced lung cancer by multicenter study
Comfort evaluation of dog apparel using 3D virtual fitting with clothing pressure across body size, movement and fabric
Differential regulation of immunoglobulin class switch recombination by the tumor suppressor p53
Abstract Immunoglobulin class switch recombination (CSR) plays an important role in humoral immune response enabling B cells to replace the initial IgM by another antibody class (IgG, IgE or IgA), thus changing the effector functions of antibodies. CSR occurs between highly repetitive switch sequences located upstream of constant gene exons, and is initiated by the Activation-Induced cytidine Deaminase via transcription-dependent deamination of single-stranded DNA targets at switch regions. CSR is preceded by germline transcription and is controlled by the super-enhancer 3′ regulatory region (3′RR) in an activation-specific manner. The 3’RR is composed of four enhancers (hs3a, hs1-2, hs3b, and hs4) which act in synergy, and its long-range activity correlates with the enhancers’ transcription. In addition to its function as a tumor suppressor, the p53 transcription factor controls various developmental and cellular processes. This multifaceted function is largely due to its context-dependent transcriptional activity, involving both activation and repression of a myriad of target genes. Despite its potential importance for CSR, which implies multiple layers of transcriptional, epigenetic and DNA break/repair regulations, the role of p53 in CSR is still unclear. Here, by using a mouse line devoid of p53, we show that p53 regulates CSR in an isotype-specific manner. Moreover, we provide evidence that p53 has a dual role in the control of germline transcription as it acts both as an activator and a repressor. Finally, we show that p53 is required for hs4 transcription, suggesting a role for p53 in the regulation of the 3’RR’s transcriptional activity.
Respiratory phase alignment across memory encoding and retrieval improves task efficiency
Single-molecule analysis reveals low-temperature misfolding in HIV-1 TAR RNA
HaploC-tools reveal haplotype-specific chromosome conformation and chromatin states
Numerical simulation of the microscopic discharge processes in SF6/N2 mixtures: Effects of gas composition, voltage, and electric field distribution
Dorsal prefrontal cortex drives perseverative behavior in mice
Abstract Perseveration – repeating one action when others would generate larger rewards – is a common behavior, but neither its purpose nor neuronal mechanisms are understood. Here we demonstrate a neural correlate and causal role of dorsal prefrontal cortex, specifically anterior secondary motor cortex (MOs) in perseveration in mice performing a dynamic reward learning task. An auditory go cue signaled mice to turn a wheel either left or right, with the reward probability of each action switching in blocks. Mice perseverated, gaining suboptimal reward, but were faster when making repeated choices. Neuropixels recordings found neurons whose activity correlated with perseveration and predicted rapid reaction times, almost exclusively in anterior MOs. Optogenetically inhibiting this region during the choice period reduced perseveration and slowed reactions. In contrast, inactivating medial prefrontal cortex at choice time had no effect, but inactivating it after reward delivery impaired learning. In this task, therefore, anterior MOs reflects a perseverative decision variable, and is necessary for mediating the effect of this decision variable on choice and reaction time.
Robust service migration for autonomous vehicles leveraging deep learning and cooperative V2V protocols
Signal-screening-guided response-contribution-correlation framework reveals instability evolution in biogas system processing organic waste
Deep learning-based double-sided fudge detection system with integrated physical components
Anti-topological crystal and non-Abelian liquid in twisted semiconductor bilayers
Abstract We show that electron crystals compete closely with non-Abelian fractional Chern insulators in the half-filled second moiré band of twisted bilayer MoTe 2 . Depending on the twist angle and microscopic model, these crystals can have non-zero or zero Chern numbers C . The C = 0 crystal occurs because contributions to the total Chern number from the full first band (+1) and half-full second band (-1) cancel. This is counterintuitive because the first two non-interacting bands in a given valley have the same Chern number + 1. For these two reasons, we call this crystal an anti-topological crystal . The anti-topological crystal is a novel type of electron crystal that may occur in systems with multiple Chern bands at filling factors n > 1.