Browse Articles

Identification of PI3K alpha inhibitors through large-scale virtual screening and integrated molecular modeling, biophysical characterization, and ADMET profiling

Evolution of overlying strata and disaster-causing mechanisms under inclined thin coal seam group mining: insights from numerical simulations

Abstract To clarify the overburden evolution and asymmetric instability mechanism during bottom-up repeated mining of an inclined thin coal seam group, a 3DEC numerical model was established based on geological conditions in Guizhou Province. The caving behavior, stress redistribution, displacement response, and simulated fracture-trace complexity of the overlying strata were analyzed during the first mining (M1), second mining (M2), and third mining (M3) stages. The results show that M1 mining mainly induces local subsidence, goaf compaction, and limited fracture development. With the successive extraction of M2 and M3, interlayer disturbance is progressively superimposed, the overburden failure range expands upward, and the stress field evolves into a zoned pattern characterized by stress relief in the goaf and stress concentration near the working face and goaf boundaries. The displacement field also shows a cumulative response, with the high-displacement zone migrating upward and the subsidence trough becoming deeper and wider. Under the 30° inclined structure, overburden deformation and failure exhibit clear dip-direction asymmetry: the high side is dominated by separation, sliding, and fracture development, whereas the low side mainly shows compaction and constrained deformation. The apparent fractal dimension of simulated fracture traces increases from 1.023 at M1 to 1.096 at M2 and 1.144 at M3, indicating enhanced relative complexity under identical discretization conditions. The overburden hazard-causing mechanism is therefore interpreted as a coupled process of stress redistribution, uncoordinated subsidence, high-side fracture development, and asymmetric instability of the load-bearing structure. These findings provide guidance for roof stability assessment and hazard control in inclined thin coal seam group mining.

Effects of dissolved surfactants in carbonated water on swelling factor and interfacial tension under sub and supercritical conditions using synthetic resinous and asphaltenic oil

Performance of CNT-enhanced GGBS/fly ash concrete for precast U-drain applications

Sustainable Ag–Cu bimetallic nanozymes derived from Juglans regia husk exhibit multifunctional catalytic, antimicrobial, and antioxidant activities

A study on cable current detection for new energy charging stations based on TMR sensor arrays

Seasonal and environmental patterns of naturally occurring parasitoids with potential to attack the invasive pest Drosophila suzukii in the Andes

Enzyme-aware soil fertility prediction using dual optimization with improved SCSO

Sequence-based prediction of drug–target binding using machine learning, deep learning and ensemble models without 3D structural information

CA1 parvalbumin interneurons display alterations of myelin patterning driven by microgliosis in temporal lobe epilepsy

Early cell-wall stress signatures enable 20-min ATR-FTIR discrimination of MRSA and MSSA

A multidimensional risk prediction framework for malignant intestinal obstruction based on machine learning: computational model development and clinical validation

Association between oxidative balance score and psychological disorders in adults

Abstract Maintaining a favorable balance between antioxidants and pro-oxidants, rather than merely increasing antioxidant intake, may be critical for mental health. This study examined the association between Oxidative Balance Score (OBS), an integrated measure of both antioxidant and pro-oxidant exposures, and odds of psychological disorders. This cross-sectional analysis used baseline data from the Isfahan Functional Disorders (ISFUN) cohort. Dietary intakes were assessed using a self-administered, Willett-format, Dish-based, 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ). OBS was calculated based on 16 dietary and 4 lifestyle factors. Depression and anxiety symptoms were evaluated using the Iranian-validated Hospital Anxiety and Depression Scale (HADS). After adjusting for confounding variables, higher OBS was significantly associated with reduced odds of depression (OR: 0.65; 95% CI: 0.49–0.86) and anxiety (OR: 0.70; 95% CI: 0.53–0.92). In sex-stratified analyses, a significant inverse association was found between OBS with depression (OR: 0.65; 95% CI: 0.45–0.93) and anxiety (OR: 0.64; 95% CI: 0.45–0.91) among women. However, there was no significant association between OBS with depression and anxiety among men. In conclusion, a higher OBS was associated with reduced odds of depression and anxiety in this population, with this inverse association being statistically significant only in women, highlighting the potential importance of a balanced antioxidant-pro-oxidant profile for mental health. Prospective studies are needed to confirm these findings.

Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection

Towards the expressive power of translating approach for knowledge graph completion

Abstract The pessimistic conclusions from previous research on the Expressive Power of translating approaches for knowledge graph completion are investigated and rethought. To this end, a novel model RosE is formulated by introducing two degrees of freedom and outperforms traditional translation-based models on widely used datasets such as , , , and . Every new freedom is a vector in the model, the operation of which multiplies with entity and relation embeddings, rotating them to a new position. Consequently, the head entity and relation embedding are equal to the tail entity. Fortunately, the intrinsic limitations merely exist in this research line when the model is trained in real vector space, not in other spaces such as trigonometric functions and complex. The experimental and theoretical results, together with the newly proposed model RosE, also confirm this conclusion. Therefore, the findings in this work do not discourage further exploration in this research line, but rather avoid those with discouraging outcomes. In short, this paper clarifies that the limitations of the translation approach for knowledge graph completion are specific conditions that only involve partial models. That is, the research line of translation approach is still promising when certain known pitfalls are avoided.

Clinical outcomes and determinants of neonatal hyperbilirubinemia among NICU admissions: a retrospective study in Ethiopia

Abstract Neonatal hyperbilirubinemia is a significant public health concern in Ethiopia, contributing to approximately 10% of neonatal mortality. This study aimed to identify the clinical outcomes and determinants of jaundice among neonates admitted to the Neonatal Intensive Care Unit (NICU) at Asella Referral and Teaching Hospital (ARTH) in South East Ethiopia. The objective of this study was to assess the magnitude of neonatal hyperbilirubinemia, its clinical outcomes, and the maternal and neonatal determinants among neonates admitted to the ARTH NICU. An institution-based retrospective cross-sectional study was conducted using systematic random sampling (K = 7), 183 neonates were selected randomly from a source population of 1,350 admissions. Data were analyzed using multivariate logistic regression to identify independent predictors of hyperbilirubinemia, with statistical significance set at p  < 0.05. The prevalence of hyperbilirubinemia was 16.4%( n  = 30; 95% CI: 11–21.8). Among these jaundiced neonates, 46.7% ( n  = 14) presented with high admission total serum bilirubin levels ranging from 15 to 19 mg/dL, and 26.7% ( n  = 8) required exchange transfusion. Inadequate breastfeeding (AOR 9.51, 95% CI: 1.24–72.67, p  = 0.030) and neonatal sepsis (AOR 3.71, 95% CI: 1.34–10.28, p  = 0.012) were the primary independent predictors. The high admission bilirubin levels and significant need for exchange transfusion highlight the urgent need for universal pre-discharge screening and robust lactation support.

Examining public acceptance intentions for government digital human through expectation confirmation and technology acceptance models

Physico-mechanical and chemical performance of Portland cement modified with eggshell powder for sustainable construction

Retrospective GIS-based spatial analysis of dengue case distribution across housing typologies in Malaysia

Workplace violence and body-worn camera use among emergency medical technicians in South Korea: a nationwide cross-sectional survey

Abstract Emergency medical technicians (EMTs) frequently experience workplace violence in prehospital settings; however, evidence on the role of body-worn cameras (BWCs) in this context is limited. This study examined the factors associated with frequent workplace violence, the perceived need for BWCs, and actual BWC use among South Korean EMTs, incorporating individual- and regional-level indicators. A nationwide cross-sectional survey was conducted among EMTs employed by provincial fire departments in South Korea. Survey data on sociodemographic characteristics, work conditions, workplace violence over the past year, and BWC-related perceptions and behaviors were linked to province-level assault indicators from the National 119 emergency medical services (EMS) Statistical Yearbook (2020–2024). The main outcomes included frequent workplace violence, high perceived need for BWCs, and BWC use. Regional assault burden was modeled as tertiles of a five-year mean provincial assault index and as a continuous measure per 10-unit increase. All primary outcomes were self-reported within a knowledge–attitude–practice (KAP) survey design. Multivariable logistic regression was performed to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). To address within-province clustering, Generalized Estimating Equations (GEE) were additionally used as a sensitivity analysis. Of 3,595 EMTs included in the descriptive analyses, 2,555 provided complete violence data. Nearly all respondents (99.7%) reported some workplace violence in the past year, and 17.3% were classified as experiencing frequent workplace violence. Overall, 64.4% reported using a BWC, and 87.9% expressed a high perceived need. Frequent violence was associated with younger age, longer EMS career, higher daily call volume, and working as an EMT rather than an ambulance driver, but not with regional assault burden. High perceived need for BWCs was more common among female EMTs and varied by age, again without clear associations with regional assault indices. In contrast, actual BWC use was associated with job position, shorter EMS career, lower call volume, and high perceived need, and was inversely associated with higher regional assault burden. Workplace violence was highly prevalent among South Korean EMTs, and the perceived need for BWCs was widespread. Individual and work-related factors, rather than province-level assault burden, were the key determinants of frequent violence and BWC-related perceptions, whereas BWC use was less common in regions with higher recorded assault indices.