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Diffuseness of coronary artery disease impacts on immediate hemodynamic and predicted clinical outcomes
Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1
Impact of electric vehicle battery recycling on reducing raw material demand and battery life-cycle carbon emissions in China
Abstract The rapid growth of electric vehicles (EVs) in China challenges raw material demand. This study evaluates the impact of recycling and reusing EV batteries on reducing material demand and carbon emissions. Integrating a national-level vehicle stock turnover model with life-cycle carbon emission assessment, we found that replacing nickel-cobalt-manganese batteries with lithium iron phosphate batteries with battery recycling can reduce lithium, cobalt, and nickel demand between 2021 and 2060 by up to 7.8 million tons (Mt) (67%), 12.4 Mt (96%), and 37.2 Mt (93%), respectively, significantly decreasing reliance on import. Moreover, battery recycling coupled with reuse can reduce carbon emissions by up to 6,532-6,864 Mt (36.0-37.9%), depending on four recycling methods employed. However, this reuse strategy delays battery recycling and risks lithium supply shortage, necessitating trade-offs between carbon reduction and material supply. Future technologies, such as lithium-sulfur and all-solid-state batteries, despite their energy efficiency, might exacerbate lithium shortage, underscoring the crucial need for increased lithium supply.
Investigating the effect of ceramic fiber on the mechanical properties of glassphalt
Body composition changes and clinical outcomes in pediatric cystic fibrosis during 24 months of lumacaftor ivacaftor therapy based on real-world data
Abstract Clinical trials demonstrate the short-term efficacy of dual CFTR modulators, but long-term real-world data is limited. We aimed to investigate the effects of 24-month lumacaftor/ivacaftor (LUM/IVA) therapy in pediatric CF patients (pwCF). This observational study included pwCF homozygous for F508del mutation treated between 2021 and 2023. We report data for the first 24 months from therapy initiation. Variables were analyzed separately for ages 2–5, 6–11, and over 12. Data from 49 pwCF (median age: 9.3 years (5.5–14.2)) showed that ppFEV1 values after a transient increase at 12 months, decreased from 102% (82–114) at baseline to 87% (74–96) at 24 months. The decrease was more pronounced with higher initial ppFEV1. Median sweat chloride concentration decreased from 75 mmol/L (69–82) to 57 mmol/L (43–70) without any association with respiratory function change. Median BMI z-score increased from − 0.81 (− 1.37–0.49) to − 0.39 (− 0.88 to − 0.04) (p = 0.288), and the proportion of underweight and overweight children decreased. Skeletal muscle mass remained stable, while fat mass significantly increased (p = 0.011). Fecal elastase levels improved, especially among younger patients. These findings underscore the potential benefits of early initiation of CFTR modulator therapy in pediatric CF patients, highlighting improvements in nutritional status and pancreatic function.
Enhanced targeted treatment of cervical cancer using nanoparticle-based doxycycline delivery system
Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells
Abstract Nanotherapy has emerged as a promising strategy for the targeted and efficient treatment of melanoma, the most aggressive and lethal form of skin cancer, with minimized systemic toxicity. However, the therapeutic efficacy of cobalt oxide nanoparticles (Co3O4NPs) in melanoma treatment remains unexplored. This study aimed to assess the therapeutic potential of Co3O4NPs in melanoma treatment by evaluating their impact on cell viability, genomic DNA and mitochondrial integrity, reactive oxygen species (ROS) generation and apoptosis induction in melanoma A-375 cells. Our findings demonstrated a concentration-dependent reduction in cell viability upon treatment with five Co3O4NP concentrations (0.2, 2, 20, 200, and 2000 µg/ml), with an IC50 value of 303.80 µg/ml. Treatment with this IC50 concentration significantly increased ROS generation, induced dramatic DNA damage, and disrupted mitochondrial membrane potential integrity. Flow cytometric analysis revealed apoptosis and necrosis induction following Co3O4NP exposure at the IC50 concentration value. Results of qRT-PCR analysis demonstrated remarkable dysregulation of apoptotic and mitochondrial genes, including a significant downregulation of apoptotic p53 and mitochondrial ND3 genes and marked upregulation of the anti-apoptotic gene Bcl2. These findings highlight the novel potential of Co3O4NPs as potent inducers of melanoma A-375 cell death in a concentration-dependent manner through excessive ROS production, genomic instability, mitochondrial dysfunction and dysregulation of apoptotic and mitochondrial gene expression, ultimately promoting apoptosis in A-375 cells. This study thus underscores the potential of Co3O4NPs as a promising nanotherapeutic candidate for melanoma treatment, warranting further exploration to elucidate their full biological and clinical applicability.
Structural and vascular assessment of the optic nerve head and macula in chronic Chagas disease
Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model
Balanced dung beetle optimization algorithm based on parameter substitution and escape strategy
Study on the vibration characteristics and influence range of buried dam pipeline
Evaluation of ozonated and ultrasonically treated corn starch as an adsorbent for patulin in buffer solutions
Abstract This study evaluates the potential of ozonated corn starch (OCS) and ultrasonicated ozonated corn starch (USOCS) as adsorbents for patulin removal in buffer solutions. The results indicated that dual modification significantly altered the starch’s structure, introducing functional groups such as carbonyl and carboxyl groups, and increasing its surface area. These modifications led to enhanced patulin adsorption capacity. Adsorption efficiency was tested across different adsorbent doses (150 mg, 200 mg, 250 mg) and contact times (15, 30, 45, and 60 min). The highest removal efficiency of 92.5% was recorded for the 250 mg dose at 60 min, with USOCS showing superior performance compared to native corn starch and OCS. Kinetic studies revealed that the pseudo-second-order model provided the best fit for the adsorption process, indicating chemisorption as the dominant mechanism. The Langmuir and Freundlich isotherms were used to describe the adsorption behavior, with a maximum adsorption capacity (q max ) of 15.19 µg/mg and a Langmuir constant (K L ) of 54.00 L/µg for the 250 mg dose. Additionally, the modified starch demonstrated consistent adsorption performance at varying concentrations, with a favorable adsorption intensity (n > 1), supporting its potential for practical applications. These findings highlight the modified corn starch as an efficient, biodegradable, and low-cost adsorbent suitable for mitigating patulin contamination in food products, offering a sustainable alternative for improving food safety.
Microfluidic mixing probe: generating multiple concentration-varying flow dipoles
Highly sensitive split ring resonator-based sensor for quality monitoring of edible oils
Study on the preparation of calcium modified coal gangue and its adsorption performance of phosphate
Determination of genetic diversity in persimmon accessions using morphological and inter simple sequence repeat markers
A real-world Pharmacovigilance study of brodalumab based on the FDA adverse event reporting system
High-resolution investigations of fault architecture in space and time
Abstract Heterogeneous fault architecture affects crustal seismotectonics and fluid migration. When studying it, we commonly rely on static conceptual models that generally overlook the absolute time dimension of fault (re)activation. Heterogenous faults, however, represent the end-result of protracted, cumulative and intricate deformation histories. This may lead to inaccurate reconstructions of tectonic histories and flowed models of fault hydro-mechanical behavior. We adopt here a multitechnique approach building upon the examination of now juxtaposed but not coeval brittle structural facies (BSF), which offer multiscalar insights in the spatio-temporal-thermal fault evolution. Our approach is applied to the Carboneras Fault, unveiling a ~ 25 Myr-long polyphase structural and thermal evolution. This led to a complex fault architecture, where BSFs exhibit a stark heterogeneity in fault rock and permeability, ultimately generating very different space- and time-dependent fault hydro-mechanical behaviors. Therefore, fault architectures shall be seen as dynamic features from which to extrapolate time-integrated comprehensive fault models accounting for the entire deformed rock volume and fault life span. We demonstrate that high-resolution studies of fault architectures are required to elucidate modes of fault growth and evolution, decipher long-lived, polyphase tectonic and thermal histories, and understand the influence of heterogenous fault architecture on hydraulic compartmentalization and earthquake rupture dynamics.