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Effects of drinking slightly acidic electrolyzed water on the growth health, blood physiology, and intestinal development in mice
LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment
Effects of reward type and previous social experience on cognitive testing outcomes of weaned dairy calves
Tailoring asymmetric RuCu dual-atom electrocatalyst toward ammonia synthesis from nitrate
Author Correction: Analysis of precancerous lesion-related microRNAs for early diagnosis of cervical cancer in the Thai population
CTDP1 and RPB7 stabilize Pol II and permit reinitiation
Identification of novel diagnostic and prognostic microRNAs in sarcoma on TCGA dataset: bioinformatics and machine learning approach
Hot season gets hotter due to rainfall delay over tropical land in a warming climate
Optimized laboratory techniques for assessing the quality of pre-stripped DMEK grafts
Canted antiferromagnetism in a spin-orbit coupled Seff = 3/2 triangular-lattice magnet DyAuGe
USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway
Impact-induced ultra-high melting point oldhamite discovered in Chang’E-6 lunar soil
Efficient CNN architecture with image sensing and algorithmic channeling for dataset harmonization
Distinct gene regulatory dynamics drive skeletogenic cell fate convergence during vertebrate embryogenesis
Abstract Cell type repertoires have expanded extensively in metazoan animals, with some clade-specific cells being crucial to evolutionary success. A prime example are the skeletogenic cells of vertebrates. Depending on anatomical location, these cells originate from three different precursor lineages, yet they converge developmentally towards similar cellular phenotypes. Furthermore, their ‘skeletogenic competency’ arose at distinct evolutionary timepoints, thus questioning to what extent different skeletal body parts rely on truly homologous cell types. Here, we investigate how lineage-specific molecular properties are integrated at the gene regulatory level, to allow for skeletogenic cell fate convergence. Using single-cell functional genomics, we find that distinct transcription factor profiles are inherited from the three precursor states and incorporated at lineage-specific enhancer elements. This lineage-specific regulatory logic suggests that these regionalized skeletogenic cells are distinct cell types, rendering them amenable to individualized selection, to define adaptive morphologies and biomaterial properties in different parts of the vertebrate skeleton.
The uncertainty inherent to DEM simulations of interlocking particles
Abstract In industrial applications, the handling of heterogeneous mixtures of phases and materials poses challenges for direct measurements and experiments, necessitating complementary modeling approaches. The Discrete Element Method (DEM) is commonly used for simulating the flow of granular systems, typically with spherical particles. However, certain applications, such as recycled polymers and batteries, require alternative non-convex particle representations in DEM simulations. Tetrapods are a promising shape candidate for modeling the flow behavior of such materials, as well as the associated uncertainty. We investigate the impact of the tetrapods’ properties on the outcome and uncertainty inherent to DEM-based simulations. We demonstrate that tetrapods are effective for modeling interlocking materials, with their shape and size parameter significantly affecting interlocking behavior. Most interestingly, we can correlate the shape and size of tetrapods to the uncertainty inherent to our simulations. Specifically, we find that this uncertainty is positively correlated with both tetrapod size and the interlocking parameter ξ/D that quantifies their non-convexity. Lastly, we provide guidelines for selecting optimal tetrapod parameter sets for accurately modeling materials based on mean and variability measured in experiments.