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Substrate-induced modulation of transient optical response of large-area monolayer MoS2
Prospective cohort study of fatigue before and after SARS-CoV-2 infection in the Netherlands
Classifying metro drivers’ cognitive distractions during manual operations using machine learning and random forest-recursive feature elimination
Mechanistic insights into nonlinear effects in copper-catalyzed asymmetric esterification
Ion-acoustic waves dynamics in magnetized cometary plasma: nonlinear periodic and super-periodic waves with ion nonextensivity
Abstract We explored the bifurcation analysis of ion-acoustic waves in a magnetized cometary plasma composed of hydrogen ions, positively and negatively charged oxygen ions, kappa-described hot solar electrons, and somewhat cooler cometary electrons. The modified Zakharov–Kuznetsov equation was derived using the reductive perturbation approach. Depending on the system’s characteristics, all conceivable phase pictures are provided, including periodic, homoclinic, and superperiodic trajectories. The presence of rarefactive and compressive solitary waves is demonstrated. Furthermore, the plasma system under discussion accommodates both nonlinear and supernonlinear periodic waves. It has been discovered that the nonextensivity of ions considerably alters the properties and has a considerable impact on the bifurcation of waves. The amplitudes of the solitary waves appear to be well connected with the existence of water molecules in cometary plasma, as well as the photoionization processes that accompany them.
Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response
Salt stress-induced remodeling of sugar transport: a role for promoter alleles of SWEET13
Abstract Sucrose, the primary carbon form synthesized by photosynthesis, is transported via the phloem for proper plant development and productivity. However, long-distance sucrose transport can become unbalanced under adverse environmental conditions. Therefore, we highlight the influence of salt stress on sugar partitioning in source versus sink tissues in sorghum under generative development including the role of stress induced sucrose transporter expression. The two sorghum genotypes displayed different responses to salinity in terms of resource allocation, in Della sugar was translocated to the stem and roots, whereas in Razinieh sugars were directed towards the grains. In Della, the unloading of sucrose in the roots was associated with increased expression levels of SbSUT6 and SbSWEET6, while in the internodes, sucrose unloading correlated with elevated levels of SbSWEET13 and the ABA-dependent transcription factor SbbZIP-TF-TRAB1. Conversely, in Razinieh, the expression of SbSUT2 in the flag internodes was linked to enhanced panicle development. In addition, a differential activation of SbSWEET13 and SbSUT6 promoters by ABA and MeJA was elucidated using dual-luciferase reporter assay in sorghum protoplasts. Finally, we arrive at a model where dynamic remodeling of sugar transport during generative development is crucial for the response to salt stress, and more manifested in sink tissues.
Determinants of response and molecular dynamics in HER2+ER+ breast cancers from the NA-PHER2 trial receiving HER2-targeted and endocrine therapies
The malignant stroke indicator is an early indicator of malignant ischemic stroke requiring decompressive hemicraniectomy
Abstract Decompressive craniectomy (DHC) can prevent mortality in patients with malignant ischemic stroke. However, no clear criteria have been established to early identify patients, who will develop malignant stroke requiring DHC. In this retrospective observational study, a large patient cohort with ischemic stroke treated between 2010 and 2021, was analyzed. Clinical and radiological parameters were analyzed. Univariate and multivariate regression analyses were performed to identify the parameters to be included in the score. A cohort of 534 patients was included. A malignant stroke indicator (MSI) score was created including age < 70 years with 7 points, midline shift with up to 6 points, unsuccessful recanalization (TICI < 2b) with 6 points, basal cistern effacement with 4 points, and CBV ASPECTS < 6 with 3 points assigned. A MSI score with a cutoff value of 9 showed a high discrimination power concerning the need for DHC (AUC 0.90, p < 0.0001). Patients with MSI-score ≥ 9 had a 22-fold higher probability of needing DHC (odds ratio 22.90, p < 0.0001). The MSI score is a promising tool to predict the need for DHC in patients at risk for developing a malignant stroke and needs to be validated in external cohorts.
CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply
A novel pressure control method for nonlinear shell-and-tube steam condenser system via electric eel foraging optimizer
PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through stabilizing chemokine mRNA in small cell lung cancer
Structural behavior of large diameter prestressed concrete cylinder pipelines subjected to strike-slip faults
Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement
Abstract Mechanisms underlying functional axonal rewiring after adult mammalian central nervous system (CNS) injuries remain unclear partially due to limited models. Here we develop a mouse intracranial pre–olivary pretectal nucleus (OPN) optic tract injury model and demonstrate that Pten/Socs3 knockout and CNTF expression in retinal ganglion cells (RGCs) promotes optic tract regeneration and OPN reinnervation. Revealed by transmission electron microscopy, trans-synaptic labeling, and electrophysiology, functional synapses are formed in OPN mainly by intrinsically photosensitive RGCs, thereby partially restoring the pupillary light reflex (PLR). Moreover, combining with Lipin1 knockdown accelerates the recovery and achieves functional reconnection after chronic injury. PLR can be further boosted by increasing RGC photosensitivity with melanopsin overexpression, and it can also be enhanced by treatment of a voltage-gated calcium channel modulator to augment presynaptic release. These findings highlight the importance of neuronal types and presynaptic activity for functional reconnection after CNS injuries.
Discovery and functional characterization of canine PD-L1-targeted antibodies for evaluating antitumor efficacy in a canine osteosarcoma xenograft model
Effects of marijuana and tobacco on male fertility and their relationship to genetic variation of mitochondrial cytochrome C oxidase genes
Abstract Although tobacco smoking declined among men at reproductive age, the use of cannabis increased. The aim of our study was to determine the impact of tobacco and cannabis on sperm quality, sperm DNA integrity tested by Chromomycin A3 (CMA3) and acridine orange (AO) and their association to genetic variants in the Cytochrome C Oxidase 1, 2 and 3 genes ( MT-CO1 , MT-CO2 , and MT-CO3 ). Semen samples were collected and divided into 37 non-smokers (NS), 39 tobacco smokers (TS), and 37 cannabis smokers (CS). MT-CO1 , MT-CO2 and MT-CO3 genes were amplified by PCR and sequenced by Sanger. The results showed reductions in normal sperm morphology and non-progressive motility in TS and CS compared to NS ( p < 0.001). However, immotile sperm, AO+, and CMA3 + scores were higher in the CS compared to TS and NS ( p < 0.001). Twenty-three nucleotide substitutions (SNPs) detected in the MT-CO1 gene, 15 SNPs detected in the MT-CO2 gene, and 30 SNPs detected in the MT-CO3 gene. None of these SNPs was different between the three groups. Tobacco and cannabis smoking altered the motility and morphology of the spermatozoa and sperm DNA integrity but was not associated with genetic variants in the MT-CO1 , MT-CO2 and MT-CO3 genes.