Nature Communications
Articles in this Issue
Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation
Abstract Mice have evolved a new dental plan with two additional cusps on the upper molar, while hamsters were retaining the ancestral plan. By comparing the dynamics of molar develo...
A multiprotein regulatory module, MED16–MBR1&2, controls MED25 homeostasis during jasmonate signaling
Cola beverage reduces risk of lead poisoning from accidental ingestion of contaminated soil particles in rat and swine models
Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice
Abstract The Nr4a nuclear hormone receptors are transcriptionally upregulated in response to antigen recognition by the T cell receptor (TCR) in the thymus and are implicated in clonal delet...
High-performance solid-state proton gating membranes based on two-dimensional hydrogen-bonded organic framework composites
A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification
Abstract Inadequate tendon healing and heterotopic bone formation result in substantial pain and disability, yet the specific cells responsible for tendon healing remain uncertain. Here we i...
A shallow-water oxygen minimum zone in an oligotrophic Tonian basin
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function
TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8+ T cell activation
Reduced contribution of sulfur to the mass extinction associated with the Chicxulub impact event
Abstract The Chicxulub asteroid impact event at the Cretaceous-Paleogene (K-Pg) boundary ~66 Myr ago is widely considered responsible for the mass extinction event leading to the demise of t...
The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions
Tunning valence state of cobalt centers in Cu/Co-CoO1-x for significantly boosting water-gas shift reaction
Herpesviruses mimic zygotic genome activation to promote viral replication
Abstract Zygotic genome activation (ZGA) is crucial for maternal to zygotic transition at the 2-8-cell stage in order to overcome silencing of genes and enable transcription from the...
Changes in event soil moisture-temperature coupling can intensify very extreme heat beyond expectations
Electrochromism via reversible electrodeposition of solid iodine
Gypsum heterogenous nucleation pathways regulated by surface functional groups and hydrophobicity
Abstract Gypsum (CaSO4·2H2O) plays a critical role in numerous natural and industrial processes. Nevertheless, the underlying mechanisms governing the formation of gypsum crystals on surface...
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
Abstract Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associat...
Hydroclimatic extremes threaten groundwater quality and stability
Abstract Heavy precipitation, drought, and other hydroclimatic extremes occur more frequently than in the past climate reference period (1961–1990). Given their strong effect on groundwater...