Nature Communications
Articles in this Issue
The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis
Abstract The development of granulomas with central necrosis harboring Mycobacterium tuberculosis (Mtb) is the hallmark o...
Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics
Optical signatures of lattice strain in chemically doped colloidal quantum wells
Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach
Abstract Epitranscriptomic modifications, particularly N6-methyladenosine (m6A), are crucial regulators of gene expression, influencing processes such as RNA stability, splicing, and transla...
Mass wasting reveals ongoing asymmetric retreat of the martian north polar ice cap
Abstract Ongoing mass wasting through ice block falls is intensive at the north polar ice cap of Mars. We monitored how this activity is currently shaping the marginal steep scarps of the ic...
Life-history adaptation under climate warming magnifies the agricultural footprint of a cosmopolitan insect pest
Abstract Climate change is affecting population growth rates of ectothermic pests with potentially dire consequences for agriculture and global food security. Ho...
Non-metallic iodine single-atom catalysts with optimized electronic structures for efficient Fenton-like reactions
Reverse mutational scanning of SARS-CoV-2 spike BA.2.86 identifies epitopes contributing to immune escape from polyclonal sera
Abstract The recently detected Omicron BA.2.86 lineage contains more than 30 amino acid mutations relative to BA.2. BA.2.86 and its JN.1 derivative evade neutralization by serum antibodies o...
Predicting metabolite response to dietary intervention using deep learning
Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering
Abstract IFNλ4 has posed a conundrum in human immunology since its discovery in 2013, with its expression linked to complications with viral clearance. While genetic and cellular studies rev...
Quantum magnetometry of transient signals with a time resolution of 1.1 nanoseconds
Refining potential energy surface through dynamical properties via differentiable molecular simulation
Early attainment of 20-hydroxyecdysone threshold shapes mosquito sexual dimorphism in developmental timing
Metal-organic cage crosslinked nanocomposites with enhanced high-temperature capacitive energy storage performance
RIF1 integrates DNA repair and transcriptional requirements during the establishment of humoral immune responses
Abstract The establishment of protective immune responses relies on the ability of terminally differentiated B cells to secrete a broad variety of antigen-specific antibodies with different...
Lipidic folding pathway of α-Synuclein via a toxic oligomer
Abstract Aggregation intermediates play a pivotal role in the assembly of amyloid fibrils, which are central to the pathogenesis of neurodegenerative diseases. The structures of fila...
Dynamic hydrogen-bonding enables high-performance and mechanically robust organic solar cells processed with non-halogenated solvent
Abstract Developing active-layer systems with both high performance and mechanical robustness is a crucial step towards achieving future commercialization of flexible and stretchable organic...
Insights into excitonic behavior in single-atom covalent organic frameworks for efficient photo-Fenton-like pollutant degradation
Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost
Abstract Neutralizing antibody titer has been a surrogate endpoint for guiding COVID-19 vaccine approval and use, although the pandemic’s evolution and the introduction of variant-adapted va...
Tracking solid electrolyte interphase dynamics using operando fibre-optic infra-red spectroscopy and multivariate curve regression
Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin
Abstract Toxic protein aggregates are associated with various neurodegenerative diseases, including Huntington’s disease (HD). Since no current treatment delays...
MethylBERT enables read-level DNA methylation pattern identification and tumour deconvolution using a Transformer-based model
Abstract DNA methylation (DNAm) is a key epigenetic mark that shows profound alterations in cancer. Read-level methylomes enable more in-depth analyses, due to their broad genomic co...
Preference for and resistance to a toxic sulfur volatile opens up a unique niche in Drosophila busckii
Abstract The ability to tolerate otherwise toxic compounds can open up unique niches in nature. Among drosophilid flies, few examples of such adaptations are known and those which are known...
Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease
Abstract Animal models that accurately reflect COVID-19 are vital for understanding mechanisms of disease and advancing development of improved vaccines and therapeutics. Pigs are in...