Nature Communications
Articles in this Issue
Transcriptome size matters for single-cell RNA-seq normalization and bulk deconvolution
Abstract The variation of transcriptome size across cell types significantly impacts single-cell RNA sequencing (scRNA-seq) data normalization and bulk RNA-seq cellular deconvolution, yet th...
Proteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy
The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus
Prompt injection attacks on vision language models in oncology
Abstract Vision-language artificial intelligence models (VLMs) possess medical knowledge and can be employed in healthcare in numerous ways, including as image interpreters, virtual scribes,...
Electronic descriptors for designing high-entropy alloy electrocatalysts by leveraging local chemical environments
PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma
The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development
Abstract Receptor-mediated signaling could be modulated by ubiquitination of pathway intermediates, but the role of such modification in the pathogenesis of inflammation and inflammation-rel...
miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape
Abstract We reported that an acquired miR-142 deficit transforms chronic phase (CP) chronic myeloid leukemia (CML) leukemic stem cells (LSCs) into blast crisis (BC) LSCs. Given the role of m...
Ground-state flavin-dependent enzymes catalyzed enantioselective radical trifluoromethylation
De novo design of protein minibinder agonists of TLR3
Abstract Toll-like Receptor 3 (TLR3) is a pattern recognition receptor that initiates antiviral immune responses upon binding double-stranded RNA (dsRNA). Several nucleic acid-based...
Machine learning-enhanced high-resolution exposure assessment of ultrafine particles
Construction of functional covalent organic framework films by modulator and solvent induced polymerization
Versatile nitrate-respiring heterotrophs are previously concealed contributors to sulfur cycle
Abstract Heterotrophic denitrifiers play crucial roles in global carbon and nitrogen cycling. However, their inability to oxidize sulfide renders them vulnerable to this toxic molecule, whic...
Measuring mean radiant temperature for indoor comfort assessment using low-resolution optical sensors
Degeneracy-breaking and long-lived multimode microwave electromechanical systems enabled by cubic silicon-carbide membrane crystals
NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts
Abstract Bunyavirales is a very large order including viruses infecting a variety of taxonomic groups such as arthropods, vertebrates, plants, and protozoa. Some bunyaviruses ar...
Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction
STICI: Split-Transformer with integrated convolutions for genotype imputation
Regeneration in the absence of canonical neoblasts in an early branching flatworm
Abstract The remarkable regenerative abilities of flatworms are closely linked to neoblasts – adult pluripotent stem cells that are the only division-competent c...
Single-cell profiling of penta- and tetradactyl mouse limb buds identifies mesenchymal progenitors controlling digit numbers and identities
Abstract The cellular interactions controlling digit numbers and identities have remained largely elusive. Here, we leverage the anterior digit and identity loss...
Artificial Intelligence (AI)-driven approach to climate action and sustainable development
Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma
Glucomannan engineering highlights roles of galactosyl modification in fine-tuning cellulose-glucomannan interaction in Arabidopsis cell walls
Abstract Widely found in most plant lineages, β-mannans are structurally diverse polysaccharides that can bind to cellulose fibrils to form the complex polysacch...