Nature Communications
Articles in this Issue
Genetics and context for precision health in Greater Boston
Metabolically flexible microorganisms rapidly establish glacial foreland ecosystems
Abstract An overriding question in ecology is how new ecosystems form. This question can be tested by studying colonisation of environments with little to no pre-existing life. Here,...
The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action
Abstract Ketamine is the first glutamatergic agent in clinical use for major depression, but its primary target remains unclear. Further research is needed to de...
Rapid amide ligation between α-halo acylsilanes and amines under aqueous conditions
A Latin American perspective on microbiome research
Abstract The human gut microbiome plays a crucial role in human health, adapting and responding to changes in diet, environment, and lifestyle. However, current microbiome research i...
Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19
scGALA advances graph link prediction-based cell alignment for comprehensive data integration and harmonization
Amorphous-amorphous transitions in granular packings
Ultranarrow electroluminescence from magnetic excitons in the van der Waals antiferromagnetic semiconductor NiPS3
First-principles full-dimensional modelling of vibrational energy transfer of molecule scattering from metal surfaces
Plastic hepatocyte states limit liver cancer development
Abstract The liver has remarkable regenerative capacity owing to the boundless proliferative potential of hepatocytes. During liver injury, sustained regeneration must be balanced by...
Solvent-mediated chirality inversion in orthogonal hierarchical assembly of achiral carbene-anchored gold cluster
A noncanonical polyamine from bacteria antagonizes host mitochondrial function
Structural basis for human chondroitin sulfate chain polymerization
Abstract Chondroitin sulfates are complex polysaccharide chains that regulate various biological processes at the cell surface and within the extracellular matri...
A DMAP-enabled strategy for C(sp2)-Si coupling of halosilanes with organic halides
GPR43 in eosinophils suppresses the emergence of pathogenic Siglec-Fhi neutrophils in allergic airway inflammation in mice
National-scale biogeography and function of river and stream bacterial biofilm communities
Abstract Biofilm-dwelling microorganisms coat the surfaces of stones in rivers and streams, forming diverse communities that are fundamental to biogeochemical processes and ecosystem...
Very long-chain fatty acids drive 1-deoxySphingolipid toxicity
Abstract 1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids formed when serine palmitoyltransferase incorporates L-alanine instead of L-serine. Elevated 1-deoxySLs are asso...
Challenging the Bredt’s rule in an acid catalyzed cationic cyclization to get bicyclo[3.3.1]nonane derivatives
Disrupted theta synchronization and synaptic connectivity in the visual cortex of Fmr1 KO mice
Acceleration, simplification and potential parallelization of digital polymers sequencing by coupling tandem mass spectrometry with ion mobility
Abstract Tailoring the structure of digital polymers is an efficient strategy for reliable reading of large amounts of data by tandem mass spectrometry. Notably, full sequence covera...
AI-augmented intraoperative decision-making workflows in diffuse midline glioma biopsy using cryosection pathology
Abstract Cryosection pathology is essential for intraoperative diagnosis of diffuse midline gliomas, yet it often leads to diagnostic errors and may prompt unnec...
A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models
Transcription start sites experience a high influx of heritable variants fueled by early development
Abstract Mutations drive evolution and genetic diversity, with the most consequential mutations occurring in coding exons and regulatory regions. However, the impact of transcription...