Nature Communications
Articles in this Issue
Discovery of selective low molecular weight interleukin-36 receptor antagonists by encoded library technologies
Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis
Gene therapy with feline anti-Müllerian hormone analogs disrupts folliculogenesis and induces pregnancy loss in female domestic cats
Abstract For female domestic cats, ovariohysterectomy is the only method of inducing permanent infertility. However, hundreds-of-millions of free-roaming cats globally highlight the necessit...
Non-local interactions determine local structure and lithium diffusion in solid electrolytes
Multi-point sensing organic light-emitting diode display based mobile cardiovascular monitor
Identification of Meibomian gland stem cell populations and mechanisms of aging
Abstract Meibomian glands secrete lipid-rich meibum, which prevents tear evaporation. Aging-related Meibomian gland shrinkage may result in part from stem cell exhaustion and is asso...
Cold seeps are potential hotspots of deep-sea nitrogen loss driven by microorganisms across 21 phyla
Single-cell analysis identifies Ifi27l2a as a gene regulator of microglial inflammation in the context of aging and stroke in mice
Non-Hermitian Dirac cones with valley-dependent lifetimes
Abstract Relativistic quasiparticles emerging from band degeneracies in crystals play crucial roles in the transport and topological properties of materials and metamaterials. Quasiparticles...
Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy
Abstract Brachyury is a transcription factor that plays an essential role in tumour growth of the rare bone cancer chordoma and is implicated in other solid tumours. Brachyury is minimally e...
AlphaFold prediction of structural ensembles of disordered proteins
Abstract Deep learning methods of predicting protein structures have reached an accuracy comparable to that of high-resolution experimental methods. It is thus possible to generate a...
Structural basis of anticancer drug recognition and amino acid transport by LAT1
Abstract LAT1 (SLC7A5) transports large neutral amino acids and plays pivotal roles in cancer proliferation, immune response and drug delivery. Despite recent advances in structural...
Proteasomes accumulate in the plant apoplast where they participate in microbe-associated molecular pattern (MAMP)-triggered pathogen defense
Abstract Akin to mammalian extracellular fluids, the plant apoplastic fluid (APF) contains a unique collection of proteins, RNAs, and vesicles that drive many physiological processes ranging...
Failure to replicate a superiority effect in crowding
Elliptical ejecta of asteroid Dimorphos is due to its surface curvature
The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation
Abstract The proteasome plays a pivotal role in protein degradation, and its impairment is associated with various pathological conditions, including neurodegenerative diseases. It is well u...
Model-constrained deep learning for online fault diagnosis in Li-ion batteries over stochastic conditions
Morphology of ejecta features from the impact on asteroid Dimorphos
Abstract Hypervelocity impacts play a significant role in the evolution of asteroids, causing material to be ejected and partially reaccreted. However, the dynamics and evolution of ejected...
Evaluation of Cas13d as a tool for genetic interaction mapping
Abstract Mapping genetic interactions (GIs) is crucial for understanding genetic network complexity. In this study, we investigate the utility of Cas13d, a CRISPR system targeting RNA, for G...
The anti-GD2 monoclonal antibody naxitamab plus GM-CSF for relapsed or refractory high-risk neuroblastoma: a phase 2 clinical trial
Abstract In this single-arm, non-randomized, phase 2 trial (NCT03363373), 74 patients with relapsed/refractory high-risk neuroblastoma and residual disease in bone/bone marrow (BM) received...
Expression of foetal gene Pontin is essential in protecting heart against pathological remodelling and cardiomyopathy
Abstract Cardiac remodelling is a key process in the development of heart failure. Reactivation of foetal cardiac genes is often associated with cardiac remodelling. Here we study the role o...
Dynamic properties of transcriptional condensates modulate CRISPRa-mediated gene activation
Protective catalytic layer powering activity and stability of electrocatalyst for high-energy lithium-sulfur pouch cell
Reply to: Failure to replicate a superiority effect in crowding
A dominant role of transcriptional regulation during the evolution of C4 photosynthesis in Flaveria species
Abstract C 4 photosynthesis exemplifies convergent evolution of complex traits. Herein, we construct chromosome-scale gen...