Nature Communications
Articles in this Issue
Explainable artificial intelligence of DNA methylation-based brain tumor diagnostics
Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure
Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel
A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis
Abstract Inositol pyrophosphates (PP-InsPs) are eukaryotic nutrient messengers. The N-terminal kinase domain of diphosphoinositol pentakisphosphate kinase (PPIP5...
Benefits of equilibrium between microbiota- and host-derived ligands of the aryl hydrocarbon receptor after stroke in aged male mice
Drug repurposing for Alzheimer’s disease and other neurodegenerative disorders
Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ
Human skeletal muscle fiber heterogeneity beyond myosin heavy chains
Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation
Abstract The tumor-suppressive function of p53 is frequently disrupted by mutations in cancers. Missense mutant p53 (mutp53) protein often stabilizes and accumulates to high levels in cancer...
Time-resolved oxidative signal convergence across the algae–embryophyte divide
Abstract The earliest land plants faced a significant challenge in adapting to environmental stressors. Stress on land is unique in its dynamics, entailing swift and drastic changes...
A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development
Abstract KRAS-dependent acinar-to-ductal metaplasia (ADM) is a fundamental step in the development of pancreatic ductal adenocarcinoma (PDAC), but the involvement of cell death pathways rema...
Boosting mechanical durability under high humidity by bioinspired multisite polymer for high-efficiency flexible perovskite solar cells
Abstract Flexible perovskite solar cells (FPSCs) with high stability in moist air are required for their practical applications. However, the poor mechanical stability under high hum...
Systematic representation and optimization enable the inverse design of cross-species regulatory sequences in bacteria
Deciphering neuronal variability across states reveals dynamic sensory encoding
Abstract Influenced by non-stationary factors such as brain states and behavior, neurons exhibit substantial response variability even to identical stimuli. However, it remains uncle...
Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases
Abstract To assess the contribution of rare coding germline genetic variants to prostate cancer risk and severity, we perform here a meta-analysis of 37,184 prostate cancer cases and 331,329...
AI-based approach to dissect the variability of mouse stem cell-derived embryo models
TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity
Spatio-temporal control of mitosis using light via a Plk1 inhibitor caged for activity and cellular permeability
Abstract The ability to control the activity of kinases spatially and temporally is essential to elucidate the role of signalling pathways in development and physiology. Progress in this dir...
Hemiphosphoindigos as a platform for chiroptical or water soluble photoswitching
Abstract Photoswitches are important molecular tools to precisely control the behavior of matter by using light irradiation. They have found application in virtually all applied chemical fie...
Single-cell imaging reveals efficient nutrient uptake and growth of microalgae darkening the Greenland Ice Sheet
Abstract Blooms of dark pigmented microalgae accelerate glacier and ice sheet melting by reducing the surface albedo. However, the role of nutrient availability in regulating algal g...
Tip carbon encapsulation customizes cationic enrichment and valence stabilization for low K+ acidic CO2 electroreduction
Abstract Acidic electrochemical CO2 conversion is a promising alternative to overcome the low CO2 utilization. However, over-reliance on highly concentrated K+ to inhibit the hydrogen evolut...
A fully conjugated meso-boron-substituted porphyrinoid combining Lewis acidity with redox-switchable aromaticity
Abstract The structural motif of porphyrin is relevant for many essential biological processes and has emerged as a versatile component of functional materials. Here, we introduce a thiophen...
Minimized optical/electrical energy loss for 25.1% Monolithic perovskite/organic tandem solar cells
Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin
Abstract The molecular basis of increased hemoglobin in Andean Aymara highlanders is unknown. We conducted an integrative analysis of whole-genome-sequencing and granulocytes transcriptomics...