Nature Communications
Articles in this Issue
Visible light-mediated dearomative spirocyclization/imination of nonactivated arenes through energy transfer catalysis
Abstract Aromatic compounds serve as key feedstocks in the chemical industry, typically undergoing functionalization or full reduction. However, partial reduction via dearomative seq...
Nanoscale heterophase regulation enables sunlight-like full-spectrum white electroluminescence
GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies
Abstract Toxoplasma gondii parasites exhibit extraordinary host promiscuity owing to over 250 putative secreted proteins that disrupt host cell functions, enabling parasite pers...
Extreme compound events in the equatorial and South Atlantic
The effects of disorder in superconducting materials on qubit coherence
Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo
Abstract We developed an efficient, robust, and broadly applicable system for light-induced protein translation to control the production of proteins of interest and study their func...
Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair
Abstract MUTYH is a clinically important DNA glycosylase that thwarts mutations by initiating base-excision repair at 8-oxoguanine (OG):A lesions. The roles for its [4Fe-4S] cofactor...
An automated framework for assessing how well LLMs cite relevant medical references
Divergent evolution of slip banding in CrCoNi alloys
Abstract Metallic materials under high stress often exhibit deformation localization, manifesting as slip banding. Over seven decades ago, Frank and Read introduced the well-known model of d...
Cryo-EM of human P-glycoprotein reveals an intermediate occluded conformation during active drug transport
A modular artificial intelligence framework to facilitate fluorophore design
Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis
Abstract The competitive advantage of mutant hematopoietic stem and progenitor cells (HSPCs) underlies clonal hematopoiesis (CH). Drivers of CH include aging and inflammation; however, how C...
Mouse MRE11-RAD50-NBS1 is needed to start and extend meiotic DNA end resection
Abstract Nucleolytic resection of DNA ends is critical for homologous recombination, but its mechanism is not fully understood, particularly in mammalian meiosis. Here we examine roles of th...
Trivalent Phospha-Brook rearrangement enabled practical deoxygenative phosphonylation of carbonyls
Fluorescent pyridine phosphonium salts via transmutation of metallabenzenes
Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells in mice
Abstract Lung tissue-resident memory T cells (TRM) are critical for the local control of respiratory tract infections caused by influenza A viruses (IAV). Here we compare TRM populations ind...
High kinetic inductance cavity arrays for compact band engineering and topology-based disorder meters
Abstract Superconducting microwave metamaterials offer enormous potential for quantum optics and information science, enabling the development of advanced quantum technologies for sensing an...
Redefining closed pores in carbons by solvation structures for enhanced sodium storage
A metal ion mediated functional dichotomy encodes plasticity during translation quality control
Reaction-driven formation of anisotropic strains in FeTeSe nanosheets boosts low-concentration nitrate reduction to ammonia
Hydrogels with prestressed tensegrity structures
scPRINT: pre-training on 50 million cells allows robust gene network predictions
Abstract A cell is governed by the interaction of myriads of macromolecules. Inferring such a network of interactions has remained an elusive milestone in cellular biology. Building...
Multimode ultrastrong coupling in three-dimensional photonic-crystal cavities
Abstract Recent theoretical studies have highlighted how spatially varying cavity electromagnetic fields enable novel cavity quantum electrodynamics phenomena, such as the Dicke superradiant...
A meta-learning approach for selectivity prediction in asymmetric catalysis
Abstract Transition metal-catalyzed asymmetric reactions are of high contemporary importance in organic synthesis. Recently, machine learning (ML) has shown promise in accelerating the devel...