Targeting PLK1-CBX8-GPX4 axis overcomes BRAF/EGFR inhibitor resistance in BRAFV600E colorectal cancer via ferroptosis

Z Zhan Zhao (Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering) J Jiashuai He S Shenghui Qiu L Lu Wang S Shuchen Huangfu Y Yangzhi Hu Q Qing Wu (Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University) Y Yabing Yang X Xiaobo Li M Maohua Huang S Shijin Liu H Hanyang Guan Z Zuyang Chen X Xiangwei Zhang Y Yiran Zhang H Hui Ding (Abteilung Struktur und Nano-/Mikromechanik von Materialien) X Xiaoxu Zhao G Guandi Xiao Y Yunlong Pan T Tongzheng Liu (State Key Laboratory of Bioactive Molecules and Druggability Assessment, and School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China) Y Yanping Wu J Jinghua Pan