Nature Communications
Articles in this Issue
Market pathways to food systems transformation toward healthy and equitable diets through convergent innovation
Top-down modulation of sensory processing and mismatch in the mouse posterior parietal cortex
Abstract An important function of the neocortex is to compare sensory feedback stimuli with internal predictions of the outside world and evoke mismatch responses to deviations, thus...
A comprehensive sulfate and DOM framework to assess methylmercury formation and risk in subtropical wetlands
Abstract Wetlands play a vital role in contaminant cycling and uptake. Understanding how sulfate (SO4 2‒) influences the conversion of inorganic mercury (Hg(II)) to toxic methylm...
Habenula contributions to negative self-cognitions
Abstract Self-related cognitions are integral to personal identity and psychological wellbeing. Persistent engagement with negative self-cognitions can precipita...
Development and external validation of prediction algorithms to improve early diagnosis of cancer
Abstract Cancer prediction algorithms are used in the UK to identify individuals at high probability of having a current, as yet undiagnosed cancer with the intention of improving early diag...
Advancing lithium metal electrode beyond 99.9% coulombic efficiency via super-saturated electrolyte with compressed solvation structure
Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology
Modular assembly of self-healing flexible thermoelectric devices with integrated cooling and heating capabilities
Abstract Flexible thermoelectric devices enable direct energy conversion between heat and electrical energy, making them ideal for wearable electronics and personal thermal management. Yet,...
Hidden structural phase transition assisted ferroelectric domain orientation engineering in Hf0.5Zr0.5O2 films
Highly efficient light-emitting diodes via self-assembled InP quantum dots
Abstract Heavy-metal-free quantum dot light-emitting diodes (QLEDs) face commercialization challenges due to low efficiency and poor stability. Spin-coated quantum dot films often create cha...
A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ channel KtrAB
Abstract K+ homeostasis is crucial for bacterial survival. The bacterial K+ channel KtrAB is regulated by the binding of ADP and ATP to the cytosolic RCK subunits KtrA. While the ligand-indu...
Tinnitus risk factors and its evolution over time
Abstract Subjective tinnitus is an auditory percept unrelated to external sounds, for which the limited understanding of its risk factors complicates the prevention and management. In this s...
Impaired ketogenesis in Leydig Cells drives testicular aging
Structure-guided design of endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing
Abstract Despite remarkable progress in designing RNA delivery systems, endosomal escape remains a recognized challenge for efficient RNA delivery. In this study, we develop a robust mRNA de...
Chelated tin halide perovskite for near-infrared neuromorphic imaging array enabling object recognition and motion perception
Mature tertiary lymphoid structures evoke intra-tumoral T and B cell responses via progenitor exhausted CD4+ T cells in head and neck cancer
Abstract Tumor tertiary lymphoid structures (TLS), especially mature TLS (mTLS), have been associated with better prognosis and improved responses to immune checkpoint blockade (ICB), but th...
Spin switchable optical phenomena in Rashba band structures through intersystem crossing in momentum space in solution-processing 2D-superlattice perovskite film
Abstract Spin-switchable phenomena are a critical element for the development of spintronic and chiroptic devices. Herein we combine a 2D-superlattice perovskite (4,4-DFPD2PbI4) film with a...
Long-term transformation in China’s steel sector for carbon capture and storage technology deployment
A chimeric viral platform for directed evolution in mammalian cells
Abstract Directed evolution is a process of mutation and artificial selection to breed biomolecules with new or improved activity. Directed evolution platforms are primarily prokaryo...
BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription
SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases
Abstract Functional tumor-specific CD8+ T cells are essential for effective anti-tumor immune response and immune checkpoint inhibitor therapy. Here we show that, compared to other o...
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019
Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson’s disease
Abstract There is strong interest in using the gut microbiome for Parkinson’s disease (PD) diagnosis and treatment. However, a consensus on PD-associated microbiome features and a mu...
Improved maximum growth rate prediction from microbial genomes by integrating phylogenetic information
Abstract Microbial maximum growth rates vary widely across species and are key parameters for ecosystem modeling. Measuring these rates is challenging, but genomic features like codo...
Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction
Abstract Blood cell phenotypes are routinely tested in healthcare to inform clinical decisions. Genetic variants influencing mean blood cell phenotypes have been used to understand d...