Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology

Ling Xie; Ryan N. Sheehy; Adil Muneer; Yan Xiong; John A. Wrobel; Feng Zhang; Kwang-Su Park; Julia Velez; Jing Liu; Yan-Jia Luo; Brent Asrican; Ping Dong; Ya-Dong Li; Corina Damian; Luis Quintanilla; Yongyi Li; Chongchong Xu; Mohanish Deshmukh; Leon G. Coleman; Guo-li Ming; Hongjun Song; Zhexing Wen; Jian Jin; Juan Song; Xian Chen

doi:10.1038/s41467-025-59128-z

Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology

L Ling Xie R Ryan N. Sheehy A Adil Muneer Y Yan Xiong J John A. Wrobel (Lineberger Comprehensive Cancer Center, University of North Carolina) F Feng Zhang K Kwang-Su Park J Julia Velez J Jing Liu Y Yan-Jia Luo B Brent Asrican P Ping Dong Y Ya-Dong Li C Corina Damian L Luis Quintanilla Y Yongyi Li C Chongchong Xu M Mohanish Deshmukh L Leon G. Coleman G Guo-li Ming H Hongjun Song Z Zhexing Wen J Jian Jin J Juan Song X Xian Chen

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published May 07, 2025

DOI 10.1038/s41467-025-59128-z

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (25)

L

Ling Xie

R

Ryan N. Sheehy

A

Adil Muneer

Y

Yan Xiong

J

John A. Wrobel

Lineberger Comprehensive Cancer Center, University of North Carolina

F

Feng Zhang

K

Kwang-Su Park

J

Julia Velez

J

Jing Liu

Y

Yan-Jia Luo

B

Brent Asrican

P

Ping Dong

Y

Ya-Dong Li

C

Corina Damian

L

Luis Quintanilla

Y

Yongyi Li

C

Chongchong Xu

M

Mohanish Deshmukh

L

Leon G. Coleman

G

Guo-li Ming

H

Hongjun Song

Z

Zhexing Wen

J

Jian Jin

J

Juan Song

X

Xian Chen

Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology

Article Details

Journal Info

Authors (25)

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