Nature Communications
Articles in this Issue
Uncovering minimal pathways in melanoma initiation
Abstract Melanomas are genetically heterogeneous, displaying mitogen-activated protein kinase mutations and homozygous loss of tumor suppressor genes. Mouse mode...
Author Correction: Support-free iridium hydroxide for high-efficiency proton-exchange membrane water electrolysis
Author Correction: Modular RNA motifs for orthogonal phase separated compartments
Daily electric field treatment improves functional outcomes after thoracic contusion spinal cord injury in rats
Abstract Spinal cord injury (SCI) can cause permanent loss of sensory, motor, and autonomic functions, with limited therapeutic options available. Low-frequency electric fields with...
Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center
Abstract Frameshifts can be caused by specific combinations of tRNA and mRNA. The wildtype AGC-decoding E. coli tRNASer3 GCU has been shown to induce −1 ribosomal frameshifting o...
Integrin beta 1 facilitates non-enveloped hepatitis E virus cell entry through the recycling endosome
Abstract Hepatitis E virus (HEV) is a major cause of acute hepatitis and mainly transmitted faecal-orally. HEV particles present in faeces are naked (nHEV), whereas those found in the blood...
Author Correction: Reconstruction of human dispersal during Aurignacian on pan-European scale
Author Correction: Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription
Abstract HIV-1 infection establishes a reservoir of long-lived cells with integrated proviral DNA that can persist despite antiretroviral therapy (ART). Certain...
Obesity drives depot-specific vascular remodeling in male white adipose tissue
Abstract Obesity-driven pathological expansion of white adipose tissue (WAT) is a key driver of endothelial dysfunction. However, early vascular alterations associated with over-nutrition al...
Author Correction: Host-derived protein profiles of human neonatal meconium across gestational ages
Purity of lithium metal electrode and its impact on lithium stripping in solid-state batteries
Abstract Recent studies emphasize that incorporating lithium metal electrodes can increase the energy density of next generation batteries. However, the production of lithium metal with high...
Abstract rule learning promotes cognitive flexibility in complex environments across species
Abstract Rapid learning in complex and changing environments is a hallmark of intelligent behavior. Humans achieve this in part through abstract concepts applicable to multiple, rela...
Structure of lymphostatin, a large multi-functional virulence factor of pathogenic Escherichia coli
Abstract Lymphostatin is a key virulence factor of enteropathogenic and enterohaemorrhagic Escherichia coli , playing rol...
Coordinated early immune response in the lungs is required for effective control of SARS-CoV-2 replication
Abstract Despite waning of virus-neutralizing antibodies, protection against severe SARS-CoV-2 in the majority of immune individuals remains high, but the underlying immune mechanisms are in...
Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice
Abstract To select appropriate behaviour, individuals must rely on encoding of relevant features within their environment in the context of current and past experiences. This functio...
Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance
Abstract IκBζ, a rather unknown co-regulator of NF-κB, can either activate or repress a subset of NF-κB target genes. While its role as an inducibly expressed, transcriptional regulator of c...
Prion-induced ferroptosis is facilitated by RAC3
Abstract Prions are infectious agents that initiate transmissible spongiform encephalopathies, causing devastating neuronal destruction in Creutzfeldt-Jakob and Kuru disease. Rapid cell deat...
Author Correction: Beta activity in human anterior cingulate cortex mediates reward biases
Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy
AAV-based delivery of RNAi targeting ataxin-2 improves survival and pathology in TDP-43 mice
Polymer microbubbles as universal platform to accelerate polymer mechanochemistry
Abstract The flow-induced activation of mechanophores embedded in linear polymers by ultrasound (US) suffers from slow mechanochemical conversions at the commonly used frequency of 20 kHz an...
Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking
Polyglutamylation of microtubules drives neuronal remodeling
Abstract Developmental remodeling shapes neural circuits via activity-dependent pruning of synapses and axons. Regulation of the cytoskeleton is critical for this process, as microtu...
ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution
Abstract Embryonal tumor with multilayered rosettes (ETMR) is a lethal embryonal brain tumor entity. To investigate the intratumoral heterogeneity and cellular communication in the tumor mic...