Nature Communications
Articles in this Issue
Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions
Abstract DNA replication is tightly regulated to occur once per cell cycle, with the MCM2-7 helicase loaded onto replication origins only during G1-phase. In higher eukaryotes, gemin...
Gate tuning of coupled electronic and structural phase transition in atomically thin Ta2NiSe5
Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in Alzheimer’s disease mouse models
Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer’s disease
Abstract Prime editing offers versatile genome modifications with therapeutic potential; yet its use to modulate neural circuitry remains underexplored. Here, we...
Dynamic changes in chloride homeostasis coordinate midbrain inhibitory network activity during reward learning
State-space kinetic Ising model reveals task-dependent entropy flow in sparsely active nonequilibrium neuronal dynamics
Abstract Neuronal ensemble activity, including coordinated and oscillatory patterns, exhibits hallmarks of nonequilibrium systems with time-asymmetric trajectories to maintain their...
A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone
Abstract Triacetic acid lactone (TAL) is a versatile platform chemical traditionally biosynthesized via decarboxylative Claisen condensation by 2-pyrone synthase...
Comparing pedestrian safety between electric and internal combustion engine vehicles
Abstract Vehicle electrification has become a major strategy for mitigating transport carbon emissions. Concerns have been raised about electric vehicle’s safety impacts due to their...
Structural insights into kainate receptor desensitization
The Endo-GeneScreen platform identifies drug-like probes that regulate endogenous protein levels within physiological contexts
Dual conversion pathways for efficient electrochemical extraction of uranium
ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer
Abstract Small cell lung cancer (SCLC) is characterized by its highly aggressive phenotype and dismal outcome. Despite the benefit of adding immune checkpoint blockade to standard ch...
Two-dimensional gradients in magnetic properties created with direct-write laser annealing
Abstract Across the fields of magnetism, microelectronics, optics, and others, engineered local variations in material properties can yield groundbreaking functionalities that play a...
Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors
Abstract The immunosuppressive tumour microenvironment (TME) remains a central barrier to effective immunotherapy in solid tumours. We present a gene-therapeutic strategy that enable...
Bidentate mixed-ligand strategy in dinuclear gold photoredox catalysis
Shared human-machine control of an intelligent bionic hand improves grasping and decreases cognitive burden for transradial amputees
Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models
Ultrastrong MXene composite fibers through static-dynamic densification for wireless electronic textiles
Abstract Inherent transverse wrinkles and resulting voids between MXene (Ti 3 C 2...
Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria
Harnessing non-equilibrium forces to optimize work extraction
Abstract While optimal control theory offers effective strategies for minimizing energetic costs in noisy microscopic systems over finite durations, a significant opportunity lies in...
Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization
Abstract Cellular stress response pathways are essential for genome stability and are frequently dysregulated in cancer. Following mitotic stress, the ubiquitin-specific protease 28...
Identification of overoxidizing and non-overoxidizing NAD-dependent methanol dehydrogenases and implications for synthetic methylotrophy
Ferroelectricity in graphene nanoribbon devices enabled by collective water molecule dynamics
Abstract Water is omnipresent in nanoscale systems, yet its collective dynamics and impact on emerging electronics remain poorly understood. Here, we investigate the role of water mo...