Nature Communications
Articles in this Issue
Ocean freshening near the end of the Mesozoic
Abstract Paleogeographic changes have significantly shaped ocean circulation and climate dynamics throughout Earth’s history. This study integrates geological proxies with climate simulation...
Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis
Author Correction: Enantioselective aza-electrophilic dearomatization of naphthalene derivatives
IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells
Abstract IRX3 is linked to predisposition to obesity through the FTO locus and is upregulated during early adipogenesis i...
A light-resuming strategy as a screening method for selecting Sec61 inhibitors down-modulating PD-L1 expression
Author Correction: Topology meets time-reversal symmetry breaking in FeSe1−xTex superconductors
The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling
Promoting implant osseointegration via the osteoblast-selective β-amino acid polymer strategy
Machine learning models highlight environmental and genetic factors associated with the Arabidopsis circadian clock
Abstract The circadian clock of plants contributes to their survival and fitness. However, understanding clock function at the transcriptome level and its response to the environment require...
Thor: a platform for cell-level investigation of spatial transcriptomics and histology
Abstract Spatial transcriptomics links gene expression with tissue morphology, however, current tools often prioritize genomic analysis, lacking integrated image interpretation. To a...
3D printing of salt-like granular polyacrylamide as sacrificial molds for shaping versatile materials
PreMode predicts mode-of-action of missense variants by deep graph representation learning of protein sequence and structural context
Optical segmentation-based compressed readout of neuronal voltage dynamics
Self-contracting, battery-free triboelectric wound healing strip with strong wet adhesion
Multi-biosensing hairband for emergency health assessment
Abstract Blood analysis is regarded as the gold standard for monitoring analytes in clinical diagnostics. However, the time-consuming and site-limited nature often delays medical interventio...
Substrate accessibility regulation of human TopIIa decatenation by cohesin
Abstract Human topoisomerase II alpha (TOP2α) resolves DNA intertwines between sister chromatids during mitosis. How cohesin, an SMC complex that holds sister chromatids, affects TOP...
Arp2/3 and type-I myosins control chromosome mobility and end-resection at double-strand breaks in S. cerevisiae
Abstract Using budding yeast, we show that Arp2/3 actin branching complex has an evolutionarily conserved role in promoting chromosome mobility of double-strand breaks (DSBs). The ra...
Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release
Characterization of ferric hydroxysulfate on Mars and implications of the geochemical environment supporting its formation
Universal quantum computation using Ising anyons from a non-semisimple topological quantum field theory
The hidden risks of CRISPR/Cas: structural variations and genome integrity
Abstract CRISPR/Cas technology has revolutionized genome engineering, unlocking unprecedented therapeutic potential. However, beyond well-documented concerns of off-target (OT) mutagenesis,...
Observation of a bilayer superfluid with interlayer coherence
Abstract Controlling the coupling between different degrees of freedom in many-body systems is a powerful technique for engineering novel phases of matter. We create a bilayer system of two-...
Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification
Abstract Cerebrospinal fluid (CSF) α-synuclein (α-syn) seed amplification assays (SAAs) can detect Lewy body pathology (LBP) with high accuracy but are invasive and costly. To address these...
SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice
Foundation neural-networks quantum states as a unified Ansatz for multiple hamiltonians
Abstract Foundation models are highly versatile neural-network architectures capable of processing different data types, such as text and images, and generalizing across various tasks like c...