Nature Communications
Articles in this Issue
RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma
Abstract Transcription factor E3 (TFE3) oncofusions are frequently detected in the Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC), a rare pediatri...
CXCR4 mediated recognition of HIV envelope spike and inhibition by CXCL12
Abstract CCR5 and CXCR4 both act as HIV co-receptors, though CXCR4 is less explored. CXCR4 binds the chemokine CXCL12 to regulate cellular processes and mediate HIV entry, a process that CXC...
Genetic tuning of retinal ganglion cell subtype identity to drive visual behavior
Abstract The distinct blend of molecular and cellular features that define neuronal subtype identity are central to shaping how individual subtypes impact animal behavior. The diversity of t...
A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution
Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohort
Diabetes reshapes pancreatic cancer-associated endothelial niche by accelerating senescence
Electronic tuning of RuO₂ polarizes metal–oxygen redox for proton exchange membrane water electrolysis
Age is an intrinsic driver of inflammatory responses to malaria
Abstract Age is a critical factor in immune responses to infection. In malaria, severe disease risk increases with age in non-immune individuals. Malaria severity is in part driven by inflam...
HFIP-assisted Brønsted acid-catalyzed ring opening of 1-azabicyclo[1.1.0]butane to access diverse C3-quaternary aza-azetidines and indole-azetidines
A predictive approach to enhance time-series forecasting
Abstract Accurate time-series forecasting is crucial in various scientific and industrial domains, yet deep learning models often struggle to capture long-term dependencies and adapt to data...
SARST2 high-throughput and resource-efficient protein structure alignment against massive databases
Single molecule spectrum dynamics imaging with 3D target-locking tracking
Abstract Fluorescence spectra offer rich physicochemical insights into molecular environments and interactions. However, imaging the dynamic fluorescence spectrum of rapidly moving biomolecu...
Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits
Minimizing interfacial energy losses via multifunctional cage-like diammonium molecules for efficient perovskite/silicon tandem solar cells
Abstract Wide bandgap (WBG) perovskites hold tremendous potential for enabling efficient perovskite/silicon tandem solar cells. However, interfacial energy losses at the perovskite/electron...
A histone-centric multi-omics study shows that increased H3K4 methylation sustains triple-negative breast cancer phenotypes
Molecular cartography of the human down syndrome and trisomic mouse brain
Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy
Abstract Degeneration of neuromuscular synapses is a key pathological feature of spinal muscular atrophy (SMA), yet cellular mechanisms underlying synapse dysfunction remain elusive. Here, w...
Aging: the wound that never starts healing
Abstract Aging is a complex biological process leading to functional decline and disease susceptibility. This article proposes that chronic activation of tissue damage response mecha...
Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A
Multimode phonon-polaritons in lead-halide perovskites in the ultrastrong coupling regime
Towards an interoperable perovskite description or how to keep track of 300 perovskite ions
Abstract Hybrid perovskites are interesting optoelectronic materials. The perovskite ABX3 structure offers a vast compositional space, and we have identified over 300 perovskite ions. This f...
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling
TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis
Keratinocyte-specific H4K12 lactylation drives a non-canonical IL-17-dependent signaling in psoriasis progression in mice
Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4
Abstract The cell-type-specific function of transcription factors (TFs) is crucial for determining cellular identity. However, it is unclear how a single TF can function specifically in diff...