Keratinocyte-specific H4K12 lactylation drives a non-canonical IL-17-dependent signaling in psoriasis progression in mice

X Xuecheng Shen W Wenxuan Qiao W Wei Yan H Hao Xie (Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences) C Chenyang Zhang (Department of Biopharmaceutics, Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Science and Medicine, Zhejiang Sci-Tech University) Y Yang Sun Q Qiong Luo (Center for Computational Quantum Chemistry, School of Chemistry, South China Normal University) Q Qiang Xu (Key Laboratory of Material Simulation Methods & Software of Ministry of Education, College of Physics)

Article Details

Volume / Issue Vol. 16, Issue 1
Published September 30, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (8)

X

Xuecheng Shen

W

Wenxuan Qiao

W

Wei Yan

H

Hao Xie

Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences

C

Chenyang Zhang

Department of Biopharmaceutics, Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Science and Medicine, Zhejiang Sci-Tech University

Y

Yang Sun

Q

Qiong Luo

Center for Computational Quantum Chemistry, School of Chemistry, South China Normal University

Q

Qiang Xu

Key Laboratory of Material Simulation Methods & Software of Ministry of Education, College of Physics