Nature Communications
Articles in this Issue
Simultaneous dual-Raman-shift scanning-free stimulated Raman scattering microscopy for label-free biomolecular imaging
Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects
Rank-dependent control of tuft and BEST4 cell development in the intestine
Abstract Specialist intestinal epithelial cells are critical for barrier integrity and immune responses at the mucosal boundary, yet the pathways that govern the...
Recurrent structural variation and recent turnover at the 17q21.31 locus in humans and great apes
Abstract The 17q21.31 locus in humans harbors several complex structural haplotypes including a ~ 970 kb inversion. Different inversion haplotypes have been asso...
Precision-guided therapy in H3K27-altered diffuse midline glioma
Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy
Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists have attracted interest as gerotherapeutics, yet clinical-trial evidence for their effects on biologic...
Extracellular electron transfer in cable bacteria enables growth rates comparable to aerobic respiration
Inferring stochastic dynamics by biophysical Neural ODE using single-cell transcriptomics
Design topological materials by reinforcement fine-tuned generative model
Scattering and induced false vacuum decay in the two-dimensional quantum Ising model
Topological stress regulates replication fork dynamics in unperturbed S phase
Two structurally mobile regions control the conformation and function of metamorphic meiotic HORMAD proteins
Abstract Metamorphic HORMA domain proteins (HORMADs) nucleate protein complex formation by refolding their mobile safety belt region to bind short closure motifs...
Role of Earth system processes in the relationship between climate change and cumulative carbon emissions
Abstract Estimates of carbon emissions budgets to limit global warming to 1.5 °C or 2 °C rely on the near-linear relationship between global temperature change a...
3D triply periodic minimal surface gyroid hydrogel scaffolds for soft tissue engineering
Abstract Engineering functional soft tissue constructs remains difficult because scaffolds must meet the mechanical, physicochemical, and biological requirements simultaneously. Here...
Redesign of TALE proteins for DNA-templated assembly of protein fibers
Abstract Many viral proteins self-assemble into capsid structures, often using their genetic material as a template for assembly. To date, de novo designed capsid-like proteins do no...
An engineered viral RNA degrader on mitochondrial surface that mitigates RNA virus infection
Mapping the canine gut microbiome: insights from the Dog Aging Project
Cross-resistance patterns in SARS-CoV-2 against 3CL protease inhibitors
Abstract SARS-CoV-2 is now endemic, with infections commonplace. While much of the population now has immunity, some subsets remain at risk. For such individuals, small-molecule anti...
Non-lytic viral immunotherapy induces long-term glioblastoma survival and tumor-specific immunity without eliciting an antiviral response
Abstract Glioblastoma is a lethal brain tumor that is resistant to conventional therapies. Here we present a non-lytic replicating retrovirus (RRV) that delivers an IL-15-receptor-li...
Olfactory tubercle mediates adaptive social behavior by controlling threat assessment and the expression of social threat memories during recall in male mice
Abstract The ability to dynamically assess and update threat responses based on changing environmental contexts is fundamental for survival. Here, we developed an odor-based paradigm...
Ultra-long-range spin coupling in graphene revealed by atomically resolved spin excitations
Abstract Magnetic interactions between localized spins-½ play a central role in quantum magnetism, spin-based quantum computing, and quantum simulation. The range and strength of the...
Organic carbon oxidation state shapes fermentative methanogenic microbiomes and controls greenhouse gas fluxes
TGFβ-mediated dural progenitor cell migration into the coronal suture is crucial for preventing craniosynostosis
Soluble uric acid suppresses neutrophil-mediated host defense in sepsis
Abstract Neutrophils are essential for host defense and inflammation, yet their dysfunction is a hallmark of acquired immunodeficiency in kidney disease, contrib...